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Serenity South -- Gardens, River-Views, and Refreshing Space

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Enjoy cooking in this well-equipped kitchen with a refrigerator, microwave, and coffee maker.
Enjoy a traditional room with a large window offering a view of a historic building, a small table, and two chairs.
Relax in a serene backyard oasis surrounded by lush greenery and a brick patio.
Kitchen features a dishwasher, stove, and ceiling fan, with a window offering a view to the outside.
A beautifully set dining table with fine china and a vase with fresh flowers.

Entire home

3 bedrooms2 bathroomsSleeps 5149 sq m

Popular amenities

  • Kitchen
  • Fireplace
  • Outdoor space
  • Parking available

Explore the area

Map
Cape Girardeau, MO
  • Riverfront Bridge Park
    ‪6 min walk‬
  • Isle Casino Cape Girardeau
    ‪16 min walk‬
  • Southeast Missouri State University
    ‪2 min drive‬
  • Cape Girardeau, MO (CGI-Cape Girardeau Municipal)
    ‪11 min drive‬

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  • Parking included
  • Free WiFi
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About the area

Cape Girardeau

On river.With a stay at this Cape Girardeau vacation home, you'll be within a 5-minute walk of Shawnee National Forest and Mississippi River. EDen Spa & Salon and Riverfront Park are also within half a mile (1 km).
View more Vacation homes in Cape GirardeauOpens in a new window

What's nearby

  • Riverfront Park - 2 min walk - 0.2 km
  • Riverfront Bridge Park - 6 min walk - 0.6 km
  • Isle Casino Cape Girardeau - 16 min walk - 1.4 km
  • Southeast Missouri State University - 2 min drive - 1.8 km
  • Show Me Center - 3 min drive - 2.8 km

Getting around

  • Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 12 min drive

Restaurants

  • ‪Sand's Pancake House - ‬11 min walk
  • ‪Burrito-Ville - ‬19 min walk
  • ‪El Mezcal Mexican Grill - ‬2 min drive
  • ‪Katy O'Ferrell's Publick House - ‬9 min walk
  • ‪Hotshots Sports Bar & Grill - ‬5 min walk

About this property

Entire place

You'll have the entire home to yourself and will only share it with other guests in your party.

Serenity South -- Gardens, River-Views, and Refreshing Space

Beautifully renovated duplex with large shared yard in Cape Girardeau Historic District. Cozy living room, large dining room, fully stocked kitchen, 3 second-story bedrooms with balcony at the end of the hall, and 1 1/2 bathes. Perfect for getting away for rejuvenation or exploring downtown. Within walking distance to local downtown restaurants, antique shops, and boutiques. Two blocks from the Mississippi River and many other attractions.

Property manager

Jo Pincosy

Languages

English

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  • Free WiFi
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Property amenities

Internet

  • Available in the house: WiFi

Parking and transportation

  • Car not required
  • Parking on site

Kitchen

  • Coffee grinder
  • Coffee/tea maker
  • Cookware, dishware, and utensils
  • Dishwasher
  • Ice maker
  • Microwave
  • Oven
  • Paper towels
  • Refrigerator
  • Spices
  • Stovetop
  • Toaster

Bedrooms

  • 3 bedrooms
  • Bedsheets provided

Bathroom

  • 1.5 bathrooms
  • Bathtub or shower
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Living spaces

  • Fireplace
  • Living room
  • Separate dining area

Entertainment

  • Books
  • DVD player
  • Games
  • TV

Outdoor areas

  • Balcony
  • Garden
  • Outdoor furniture

Laundry

  • Laundromat nearby

Comfort

  • Air conditioning
  • Heating

Pets

  • No pets allowed

Suitability/Accessibility

  • Smoking not allowed

Services and conveniences

  • Iron/ironing board

Location highlights

  • Near a health/beauty spa
  • Near a hospital
  • Near an outlet shopping mall
  • On a river

Things to do

  • Water park
  • Basketball nearby
  • Casino nearby
  • Cycling nearby
  • Fishing nearby
  • Golfing nearby
  • Hiking/biking trails nearby
  • Horseback riding nearby
  • Motor boating nearby
  • Swimming nearby
  • Wildlife walks nearby
  • Winery tours nearby

Safety features

  • Carbon monoxide detector (host has indicated there is a carbon monoxide detector on the property)
  • Smoke detector (host has indicated there is a smoke detector on the property)
  • Deadbolt lock

General

  • Garden
  • Unit size: 1,600 square feet

Policies

Check-in

Check-in time starts at 4:00 PM
Minimum check-in age: 18

Check-out

Check-out before 11:00 AM

Special check-in instructions

You will receive an email from the host with check-in and check-out instructions

Pets

  • No pets allowed

Children and extra beds

  • Children are welcome.
  • Note from host: Excellent fenced back yard.

Important information

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
Parties and events (including family gatherings, birthday parties and weddings) are allowed on site; maximum attendees: 50
Note from host: Parties or events must okayed before arrival.
Host has indicated there is a carbon monoxide detector on the property
Host has indicated there is a smoke detector on the property
Safety features at this property include a deadbolt lock
This property is managed through our partner, Vrbo. You will receive an email from Vrbo with a link to a Vrbo account, where you can change or cancel your reservation
Charges for extra guests may apply and vary according to property policy.
A cash deposit, credit card, or debit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. Parties and events (including family gatherings, birthday parties and weddings) are allowed on site. Maximum attendees: 50. Note from host: Parties or events must okayed before arrival. For guests' safety, the property includes a carbon monoxide detector, a smoke detector, and a deadbolt lock in each accommodation.

Serenity South -- Gardens, River-Views, and Refreshing Space Reviews

Reviews

10

Exceptional

Rating 10 - Excellent. 133 out of 136 reviews
Rating 8 - Good. 3 out of 136 reviews
Rating 6 - Okay. 0 out of 136 reviews
Rating 4 - Poor. 0 out of 136 reviews
Rating 2 - Terrible. 0 out of 136 reviews

10/10

Cleanliness

10/10

Property conditions & facilities

Reviews

10/10 Excellent

Mark H.

Liked: Cleanliness
Stayed 2 nights in Jun 2025

10/10 Excellent

Bryan P.

Liked: Cleanliness

Comfortable & Clean

Great Location short walking distance to the Downtown Area with lots do do, Restaurants, Water Park, Shopping. This is the 2nd time I have stayed and it is a true delight. Very spacious and comfortable. Easy to communicate with the Owner/Manager. I will be staying there again in the future. I recommend it with 5 Stars!
Stayed 1 night in Jun 2025

10/10 Excellent

Vicki R.

Liked: Cleanliness
Beautiful house. Great stay. Would definitely stay again!
Stayed 1 night in Jun 2025

10/10 Excellent

Linden S.

Liked: Cleanliness

A Beautiful Retreat for Three Generations

Three generations found rest,beauty,& joy at Serenity South. Thoughtful touches,beautiful gardens and Cape charm made this more than a stay-it became a treasured memory. We were so appreciative of the details, the fresh flowers, homemade cookies, the coffeemaker upstairs and the books and games. The beds were all comfortable. We enjoyed this historical home and our stay.
Stayed 2 nights in May 2025

10/10 Excellent

STEPHANIE L.

Liked: Cleanliness

In town for one day

Its was different, but over all it was on point.I will rebook this summer
Stayed 1 night in May 2025

10/10 Excellent

Sam E.

Liked: Cleanliness

Downtown home with great character

My son and two brothers stayed a night in this lovely home. I travel to Cape frequently to visit my son and will definitely stay here again.
Stayed 1 night in Apr 2025

10/10 Excellent

Michelle K.

Liked: Cleanliness

Perfect home for college visit

When looking for a VRBO for our daughter's college visit, we knew the perfect place to stay! This is our second stay at Serenity South and it was just as incredible as the first visit. Clean, inviting and cozy. Thanks Jo for another beautiful stay.
Stayed 1 night in Feb 2025

10/10 Excellent

Penny F.

Liked: Cleanliness

Beautiful getaway!

The property was exactly as listed with so many little touches that made it special. Communication was great and we were close to downtown shops and the casino. We will definitely stay again when we are in the area.
Stayed 2 nights in Mar 2025

10/10 Excellent

Vickie M.

Liked: Cleanliness
Stayed 1 night in Feb 2025

10/10 Excellent

Rhonda S.

Liked: Cleanliness

Smith Women’s Weekend

We had a wonderful time at Serenity South! The house is quiet and very clean, in walking distance of fantastic shops and fun places to eat. We look forward to returning next year!
Stayed 2 nights in Feb 2025

10/10 Excellent

shirley g.

Liked: Cleanliness

Outstanding

Here for a volleyball tournament. Had 3 short days to enjoy this beautiful home. Just not long enough. Has everything u need and more. Jo is a lovely host. So quiet and peaceful.. most of all in a safe area. I plan to go back by summers end just so I can enjoy the home and walk to coffee shop and tour the old part of town. Just wonderful!
Stayed 3 nights in Feb 2025

10/10 Excellent

Jennifer K.

Liked: Cleanliness

This property is excellent

This is an older home (1920’s?) with so much charm. It’s exceptionally well cared for - the floors are clean and in excellent condition, the walls are clean, paint job is beautiful, etc. The air is clean (no smell of mold) bathroom fans work, etc! In short, one of the best maintained rentals we’ve stayed in. The beds are comfy. Oh - and the landscaping is also beautiful! It is winter - would love to see the gardens in the spring. Jo was easy to contact, check in was easy. The trains do run 1 or 2 times per night and are close and on Friday night there were some people having fun running their loud cars through town but otherwise it is quiet and peaceful. The walk to town is only a few blocks. We would definitely stay here again!
Stayed 4 nights in Dec 2024

10/10 Excellent

Michelle A B.

Liked: Cleanliness

Great stay!

This was the second year in a row that we have stayed here. This is a beautiful home to stay in. I love the charm and detail of the house. We stay here after a Christmas party and walk downtown so it’s definitely located in a convenient spot. I will be booking again for next year Great communication with Jo and if there’s any questions I need, Jo is very quick to respond. Thank you for making our stay good!
Stayed 1 night in Dec 2024

10/10 Excellent

Steve B.

Liked: Cleanliness

Excellent choice

Very nice property. Highly recommend.
Stayed 2 nights in Oct 2024

10/10 Excellent

joe R.

Liked: Cleanliness

Cape Girardeau

Beautiful very clean house with a lot of character
Stayed 1 night in Oct 2024

10/10 Excellent

Debbie K., Little Rock, USA

Liked: Cleanliness

Very charming house

We stayed at Serenity South instead of a hotel for family weekend. We were able to have our daughter and her friends over for dinner which we could never do in a hotel! There are great views from upstairs.
Stayed 1 night in Sep 2024

10/10 Excellent

Scott R.

Liked: Cleanliness

Family visit

Nice property, real close to downtown and the river. Very relaxing
Stayed 2 nights in Sep 2024

10/10 Excellent

Maggie M.

Liked: Cleanliness
Stayed 2 nights in Aug 2024

10/10 Excellent

Tracy H., Lodi

Liked: Cleanliness

Great location and responsive

We were a last minute stay and Jo quickly accommodated. She had the air conditioning on for us and fresh flowers. So wonderful
Stayed 3 nights in Aug 2024

10/10 Excellent

Mom 2.

Liked: Cleanliness

Serenity South is out favorite place in Cape.

I have stayed at Serenity South three times in the last 5 months. It is perfectly located near downtown restaurants and the Old St. Vincent's church, and it is literally a 2 minute drive to SEMO's River Campus. We will be returning to Cape next month, but sadly, this property was already booked. It will always be my first choice, though.
Stayed 2 nights in Aug 2024

10/10 Excellent

Bradley T.

Liked: Cleanliness

Peaceful place

Very nice and beautiful place super nice people
Stayed 2 nights in Jun 2024

10/10 Excellent

Tony&Julie B.

Liked: Cleanliness

Cute comfortable duplex

Nice comfortable accomodations very clean. The kitchen had everything you needed. Easy area to get around the Saturday Farmers market down the street was nice
Stayed 3 nights in May 2024

10/10 Excellent

Candice L.

Liked: Cleanliness

Family Graduation

The place was perfect for our stay and was close to the farmers market and downtown shops. Highly recommend for location!
Stayed 1 night in May 2024

10/10 Excellent

Melissa M.

Liked: Cleanliness

Charming, beautifully maintained home

Lovely house, well maintained and stocked. Nice bed linens and towels. Lots of thoughtful features like a coffee and tea station upstairs with the bedrooms. The host even left fresh cookies for us in the kitchen. Beautiful gardens with cut flowers. Fantastic location just blocks from shopping, restaurants and bars. Highly recommend.
Stayed 2 nights in Apr 2024

10/10 Excellent

Terry M., St. Louis

Liked: Cleanliness

Great family getaway

Everything was perfect. From check in to check out. Great neighborhood and location.
Stayed 1 night in Apr 2024