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21c Museum Hotel Louisville

4.5 star property
4.5-star luxury hotel near Louisville Slugger Museum

Choose dates to view prices

Photo gallery for 21c Museum Hotel Louisville

Front of property
Fountain
Room (Asleep in the Cyclone)
Breakfast, lunch and dinner served
Room (Asleep in the Cyclone)

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Spa
  • Pet friendly
  • Free WiFi
  • Air conditioning
  • Gym

Explore the area

View in a map
700 W Main Street, Louisville, KY, 40202
  • Place, 21c Museum Hotel
    ‪1 min walk‬
  • Place, Louisville Slugger Museum
    ‪3 min walk‬
  • Place, KFC Yum Center
    ‪8 min walk‬
  • Airport, Louisville, KY (SDF-Louisville Intl.)
    ‪10 min drive‬

Room options

View all photos for Deluxe Double Room, 2 Double Beds

Deluxe Double Room, 2 Double Beds

Deluxe Double Room, 2 Double Beds

9.6 out of 10
Exceptional
(31 reviews)
  • 31 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Double Beds

View all photos for Luxury Double Room, 2 Double Beds

Luxury Double Room, 2 Double Beds

Luxury Double Room, 2 Double Beds

9.0 out of 10
Wonderful
(2 reviews)
  • City view
  • 40 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed

9.6 out of 10
Exceptional
(71 reviews)
  • 33 sq m
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed

View all photos for Luxury Room, 1 King Bed

Luxury Room, 1 King Bed

Luxury Room, 1 King Bed

9.0 out of 10
Wonderful
(34 reviews)
  • City view
  • 42 sq m
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed

View all photos for Suite, Corner

Suite, Corner

Suite, Corner

  • City view
  • 61 sq m
  • Sleeps 3
  • 1 King Bed

View all photos for Room (Asleep in the Cyclone)

Room (Asleep in the Cyclone)

Room (Asleep in the Cyclone)

  • 46 sq m
  • Sleeps 3
  • 1 King Bed

View all photos for Suite (Atrium)

Suite (Atrium)

Suite (Atrium)

  • 54 sq m
  • Sleeps 3
  • 1 King Bed

View all photos for Room, Balcony

Room, Balcony

Room, Balcony

10.0 out of 10
Exceptional
(1 review)
  • City view
  • 29 sq m
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Double Room, Accessible

Designer toiletries, hair dryer, bathrobes, towels

Deluxe Double Room, Accessible

9.0 out of 10
Wonderful
(2 reviews)
  • 42 sq m
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

10.0 out of 10
Exceptional
(2 reviews)
  • 40 sq m
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

10.0 out of 10
Exceptional
(1 review)
  • 40 sq m
  • Sleeps 3
  • 1 King Bed

View all photos for Apartment, 1 Double Bed (Rooftop)

Apartment, 1 Double Bed (Rooftop)

Apartment, 1 Double Bed (Rooftop)

  • City view
  • Sleeps 4
  • 1 Double Bed

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About the area

Louisville

Downtown Louisville stay.A stay at this Downtown Louisville hotel places you steps from Louisville Slugger Museum and within a 10-minute walk of KFC Yum Center. Ohio River Valley and 21c Museum Hotel are also within half a mile (1 km).

What's nearby

  • 21c Museum Hotel - 1 min walk - 0.0 km
  • Muhammad Ali Center - 3 min walk - 0.3 km
  • Louisville Slugger Museum - 3 min walk - 0.3 km
  • Kentucky International Convention Center - 8 min walk - 0.7 km
  • KFC Yum Center - 8 min walk - 0.7 km

Getting around

  • Louisville Intl. Airport (SDF) - 10 min drive

Restaurants

  • ‪Jockey Silks Bourbon Bar - ‬7 min walk
  • ‪Heine Brothers' Coffee - ‬3 min walk
  • ‪Swizzle - ‬8 min walk
  • ‪Vincenzo's Italian Restaurant - ‬5 min walk
  • ‪Mussel & Burger Bar - ‬1 min walk

About this property

21c Museum Hotel Louisville

4.5-star luxury hotel near Louisville Slugger Museum
21c Museum Hotel Louisville offers its guests a full-service spa and a 24-hour fitness center. There's a restaurant on site. You can enjoy a drink at the bar/lounge. A computer station is on site, and both WiFi and wired Internet are free in public spaces.

A 24-hour business center, meeting rooms, and limo/town car service are available. Event space at this hotel measures 5000 square feet (465 square meters) and includes conference space. Spa services, multilingual staff, and gift shops/newsstands are also featured at the luxury 21c Museum Hotel Louisville. Parking is available for a fee.

This 4.5-star Louisville hotel is smoke free.

  • 1 building
  • 91 guestrooms or units
  • 4 levels
  • Meeting rooms
  • 5000 sq ft of conference space
  • 465 sq m of conference space
  • Built in 2006
  • Charging station for electric cars
  • Business center (24 hours)
  • Conference space
  • Breakfast available (surcharge)
  • Coffee in lobby
  • Dry cleaning
  • Self-service laundry
  • Front desk (24 hours)
  • Staff is multilingual
  • Storage area for luggage
  • Front-desk safe
  • Car service
  • Tour and ticket information
  • Concierge
  • Gift shop
  • ATM
  • Bellhop
  • Elevator
  • No smoking on site
  • Bar or lounge
  • Dining venue
21c Museum Hotel Louisville offers 91 accommodations with minibars and laptop-compatible safes. Beds feature down comforters and premium bedding. 50-inch LCD televisions come with premium cable channels. Bathrooms include bathrobes, designer toiletries, complimentary toiletries, and hair dryers.

This Louisville hotel provides complimentary wired and wireless Internet access. Business-friendly amenities include desks along with free local calls (restrictions may apply). Additionally, rooms include espresso makers and complimentary bottled water. In-room massages and hypo-allergenic bedding can be requested. Housekeeping is provided daily.

21c Spa has 2 treatment rooms. Services include deep-tissue massages, hot stone massages, sports massages, and Swedish massages. The spa is equipped with a sauna and a steam room. The spa is open daily.

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Property amenities

Family friendly

  • In-room crib
  • Laundry facilities
  • Rollaway/extra bed (surcharge)
  • Soundproofed rooms

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transportation

  • Electric car charging station on site
  • Limo/town car service
  • Valet parking on site (USD 32 per night; includes in/out privileges)
  • Wheelchair-accessible parking available

Food and drink

  • Full breakfast available for a fee 7:00 AM to 10:00 AM on weekdays and 8:00 AM to 1:00 PM on weekends; USD 5 to 25 per person
  • A bar/lounge
  • A restaurant
  • Coffee and tea in common areas

Things to do

  • 24-hour gym
  • Full-service spa
  • Yoga classes

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Elevator
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible registration desk

Room amenities

Entertainment

  • 50-inch LCD TV with premium cable channels
  • iPod dock

Bedroom

  • Blackout drapes
  • Down comforter
  • Free crib
  • Hypo-allergenic bedding
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathrobes
  • Designer toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Food and drink

  • Champagne service
  • Espresso maker
  • Free bottled water
  • Limited room service
  • Minibar

More

  • Air conditioning (climate-controlled)
  • Cleaning products are eco-friendly
  • Connecting rooms available
  • Desk
  • Eco-friendly toiletries
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • LED lighting
  • Soundproofed rooms
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4 PM; Check-in end time: midnight
Contactless check-in available
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • Pets: USD 40.00 per accommodation, per stay
  • Weight limit: 50 lbs per pet
  • Food and water bowls are available
  • Service animals are exempt from fees

Children and extra beds

  • Children are welcome.
  • Rollaway/extra beds are available for USD 30.0 per night.
  • Free cribs (infant beds)!

Property payment types

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Service fee: USD 5.00 per accommodation, per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for full breakfast: approximately USD 5 to 25 per person
  • Valet parking fee: USD 32 per night (in/out privileges)
  • Pet fee: USD 40.00 per accommodation, per stay
  • Service animals are exempt from fees
  • Rollaway bed fee: USD 30.0 per night

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards; cash is not accepted
This property uses eco-friendly cleaning products
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards
This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels)
Charges for extra guests may apply and vary according to property policy.
A credit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation. This property accepts Visa, Mastercard, American Express, and Discover. Cash is not accepted. This property uses eco-friendly cleaning products.
    For guests' safety, the property includes a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards in each accommodation. This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels).

We should mention

  • Reservations are needed for massage services. For reservations, contact the hotel before arrival using the contact information on the booking confirmation.
  • Connecting/adjoining rooms are subject to availability and can be requested by contacting the property at the number on your booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

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21c Museum Hotel Louisville Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 775 out of 1002 reviews
Rating 8 - Good. 131 out of 1002 reviews
Rating 6 - Okay. 59 out of 1002 reviews
Rating 4 - Poor. 20 out of 1002 reviews
Rating 2 - Terrible. 17 out of 1002 reviews

9.6/10

Cleanliness

9.4/10

Staff & service

9.0/10

Amenities

9.6/10

Property conditions & facilities

Reviews

10/10 Excellent

Daniel

Stayed 5 nights in Feb 2026

10/10 Excellent

DONALD, Louisville

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Attractive, comfortable rooms are as nice as any in the downtown area. On Museum Row, close to Lou Slugger Museum, Frazier History Museum. 10 min. walk to Bourbon Row. On site rest. very good, but pricy. Would definitely stay again. Ten, of course!
Stayed 2 nights in Jan 2026

10/10 Excellent

Brian, Dakota Dunes

Stayed 1 night in Jan 2026

10/10 Excellent

Morgan

Stayed 1 night in Jan 2026

10/10 Excellent

Lorie

Liked: Cleanliness, staff & service, amenities
All the staff were great! The rooms were clean the coffee was great. I would stay here again.
Stayed 2 nights in Jan 2026

10/10 Excellent

Frank

Stayed 1 night in Jan 2026

6/10 Okay

Carol

Travelled with partner
Liked: Cleanliness
Disliked: Amenities, property conditions & facilities
The bed was comfortable.The art exhibits were closed down. I wish I'd known beforehand as I probably wouldn't have booked. The shower gel dispenser was empty. Just not what I had expected from a boutique hotel.
Stayed 1 night in Jan 2026

10/10 Excellent

Jeremy

Liked: Cleanliness, staff & service, amenities
Everything was great! We always love staying at the 21C!
Stayed 1 night in Dec 2025

10/10 Excellent

Anatole

Liked: Cleanliness, amenities, property conditions & facilities
Excellent place.
Stayed 1 night in Jan 2026

10/10 Excellent

Leslie

Stayed 2 nights in Dec 2025

10/10 Excellent

Daniel

Stayed 3 nights in Dec 2025

10/10 Excellent

Nathalie

Stayed 1 night in Dec 2025

10/10 Excellent

Kevin

Liked: Cleanliness, staff & service, amenities
The room was great! The bar was fantastic. The hotel accommodated all of my requests. My husband and I have stayed here a few times. I'm truly grateful for the kindness of the staff.
Stayed 1 night in Dec 2025

8/10 Good

Amy

Stayed 3 nights in Dec 2025

10/10 Excellent

Tammy

Travelled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Staff was very kind, the art was fantastic, location was perfect to explore Whiskey Row, and we had a gorgeous room. Loved our time away there!
Stayed 1 night in Dec 2025

10/10 Excellent

Susan

Stayed 1 night in Dec 2025

10/10 Excellent

Briana

Yes
Stayed 1 night in Dec 2025

10/10 Excellent

Wade

Stayed 1 night in Dec 2025

10/10 Excellent

Frank

Stayed 1 night in Dec 2025

10/10 Excellent

Chase

Stayed 1 night in Nov 2025

6/10 Okay

richard

Stayed 1 night in Nov 2025

6/10 Okay

Annamarie

Stayed 1 night in Nov 2025

8/10 Good

Sandra

Travelled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Hotel was roomy, loved the size of our room and how we could stretch out. Pillows were less than to be desired. Wish I had brought my own because it made for uncomfortable sleeping. But hotel was quiet and in a decent location. Loved the water bottles!
Stayed 1 night in Nov 2025

10/10 Excellent

pamela

Liked: Cleanliness, property conditions & facilities
Lovely comfortable place to stay !
Stayed 1 night in Nov 2025

10/10 Excellent

Jacquelyn

Stayed 1 night in Nov 2025