Poplar Bluff Vacations 2025/2026

Top Poplar Bluff hotels deals

Motel 6 Poplar Bluff, MO

4101 Highway 67 N, Poplar Bluff, MO

Free cancellation

Reserve now, pay when you stay

CA $109

CA $115 total

Sep 9 - Sep 10

includes taxes & fees

Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located nearby.

Pet-friendly

Parking included

Fairfield Inn & Suites by Marriott Poplar Bluff

3109 Oak Grove, Poplar Bluff, MO

Free cancellation

Reserve now, pay when you stay

CA $137

CA $155 total

Sep 14 - Sep 15

includes taxes & fees

Book a stay at this business-friendly hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located nearby.

Pool

Breakfast included

Hampton Inn Poplar Bluff

2420 Crestwood Dr, Poplar Bluff, MO

Free cancellation

Reserve now, pay when you stay

CA $134

CA $150 total

Sep 14 - Sep 15

includes taxes & fees

Stay at this hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located nearby.

Pool

Breakfast included

Drury Inn & Suites Poplar Bluff

2220 N Westwood Blvd, Poplar Bluff, MO

Free cancellation

Reserve now, pay when you stay

CA $130

CA $147 total

Sep 14 - Sep 15

includes taxes & fees

Stay at this 3-star business-friendly hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located nearby.

Pool

Hot tub

Holiday Inn Poplar Bluff by IHG

2781 N Westwood Blvd, Poplar Bluff, MO

Free cancellation

CA $134

CA $152 total

Sep 14 - Sep 15

includes taxes & fees

Stay at this 3-star business-friendly hotel in Poplar Bluff. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located nearby.

Pool

Pet-friendly

Super 8 by Wyndham Poplar Bluff Missouri

2831 N Westwood Blvd, Poplar Bluff, MO

Free cancellation

Reserve now, pay when you stay

CA $81

CA $92 total

Sep 14 - Sep 15

includes taxes & fees

Book a stay at this business-friendly motel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located nearby.

Breakfast included

Pet-friendly

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Poplar Bluff Regional Medical Center

Though Poplar Bluff Regional Medical Center might be what brings you to town, perhaps you'll have a chance to explore more of Poplar Bluff while you are here.

Black River Coliseum

Catch an event at Black River Coliseum during your trip to Poplar Bluff. While in this family-friendly area, you can enjoy the restaurants.

Margaret Harwell Art Museum

You can study the exhibits at Margaret Harwell Art Museum, a museum with a storied past, during your travels to Poplar Bluff. Stroll along the riverfront or experience the entertainment venues in this family-friendly area.

Frequently asked questions

How much are vacation packages to Poplar Bluff?

Vacation packages, which include flights and hotels in Poplar Bluff, start from as low as . Make your travel fantasies come to life and begin your booking with Travelocity today.

How long should my Poplar Bluff vacation be?

About 2 nights is what many travelers book for their Poplar Bluff trip. That's a good base to start from, but there's so much more to explore if you give yourself a couple of extra days.

Where can I get the best vacation package deals for Poplar Bluff?

Look no further than Travelocity. With access to 400 airlines and an impressive 1,000,000 properties across the globe, selecting the perfect Poplar Bluff package deal couldn't be easier.

Why should I purchase my Poplar Bluff vacation package via Travelocity?

We take the stress out of travel planning. Whether you're seeking an amazing new place to uncover or want to ensure you get the best price on offer, we're here to assist. Our 24/7 support, top-quality service and Price Match Guarantee mean you can confidently book with Travelocity.

Will I save money on my Poplar Bluff car rental if I combine it with hotels and flights?

With a Poplar Bluff vacation package, you can combine your car, flight and hotel bookings and save a ton. If you can't wait to discover the best of this awesome region, why not make tracks to Orpheum Theatre? This popular sight is 177 kilometers from Poplar Bluff. With your own set of wheels, you'll be there in a jiffy.

Which airport is best for Poplar Bluff?

Jetting to Poplar Bluff will see you touching down at Cape Girardeau Municipal Airport (CGI). It's situated 88 kilometers northeast of the downtown area.

What is there to do in Poplar Bluff?

While taking the path less traveled can be rewarding, you shouldn't miss the big sights that make a destination famous. Margaret Harwell Art Museum and Mo-Ark Regional Railroad Museum are just two of them in Poplar Bluff.

Where should I stay when visiting Poplar Bluff?

If you're searching for someplace comfortable to spend your nights, take a look at the Fairfield Inn & Suites by Marriott Poplar Bluff. It's the top choice for many travelers.