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Hotels near South Central Houston

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD Houston TX
Fully refundableReserve now, pay when you stay
The price is CA $210 per night from Apr 1 to Apr 2
CA $210
CA $261 total
Apr 1 - Apr 2
includes taxes & fees
Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ...
Yes

Reviewed on Mar 4, 2026

Opens in a new windowThe Westin Houston Medical Center/Museum District
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St Houston TX
Fully refundable
The price is CA $231 per night from Apr 3 to Apr 4
CA $231
CA $298 total
Apr 3 - Apr 4
includes taxes & fees
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
Amazing hotel. Beautiful property, wonderful customer service.

Reviewed on Mar 6, 2026

Opens in a new windowInterContinental Houston by IHG
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
Book a stay at this luxury aparthotel in Houston. Enjoy free WiFi, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
Room was fine. Just every morning at breakfast their landscaper was using a gas blower that ruined the whole experience. Very loud. No common sense to not have that done or switch to electric so there is no noise. Also area is not walkable to any restaurants. Sorta in a bad spot.

Reviewed on Mar 6, 2026

Opens in a new windowHotel Zaza Houston Museum District
Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

4 out of 5
6580 Fannin Street Houston TX
Fully refundableReserve now, pay when you stay
The price is CA $245 per night from Apr 3 to Apr 4
CA $245
CA $331 total
Apr 3 - Apr 4
includes taxes & fees
Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), a free area shuttle, and room service. Our guests praise the helpful staff ...
Old facility; uncomfortable beds and furniture; crispy carpet in room (yuk!); limited onsite dining; noisy area with emergency vehicles coming and going to nearby hospitals, hotel patio area on 4th floor was dirty, not well maintained, and very uninviting. Definitely not worth the per night room ...

Reviewed on Mar 4, 2026

Opens in a new windowHouston Marriott Medical Center/Museum District
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
The price is CA $136 per night from Mar 29 to Mar 30
CA $136
CA $160 total
Mar 29 - Mar 30
includes taxes & fees
Book a stay at this luxury hotel in Houston. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in our ...
None

Reviewed on Mar 3, 2026

Opens in a new windowHilton Houston Plaza/Medical Center
Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown

2 out of 5
2510 Hamilton St Houston TX
Fully refundableReserve now, pay when you stay
The price is CA $125 per night from Apr 1 to Apr 2
CA $125
CA $147 total
Apr 1 - Apr 2
includes taxes & fees
Stay at this hotel in Houston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Toyota Center and Daikin Park are located nearby.
We stayed at this motel for two days and had a really great experience. The person who welcomed us was extremely kind, friendly, and always available to help with anything we needed — that kind of attitude really makes a difference when you’re traveling. The motel is conveniently located close to ...

Reviewed on Mar 3, 2026

Opens in a new windowDowntowner Inns - Houston Downtown
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4 out of 5
6800 Main Street Houston TX
Fully refundableReserve now, pay when you stay
The price is CA $162 per night from Mar 30 to Mar 31
CA $162
CA $190 total
Mar 30 - Mar 31
includes taxes & fees
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
The room was gorgeous and I even got warm cookies upon check in!

Reviewed on Mar 1, 2026

Opens in a new windowDoubleTree by Hilton Houston Medical Center Hotel & Suites
Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown

2 out of 5
2419 Riverside Dr Houston TX
Fully refundableReserve now, pay when you stay
The price is CA $135 per night from Mar 23 to Mar 24
CA $135
CA $158 total
Mar 23 - Mar 24
includes taxes & fees
Stay at this motel in Houston. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Did not know by the pictures that this was a motel, not a hotel. They did not have a room on the first floor which posed problems for my husband and I due to age and health reasons. We thought there would be an elevator, not stairs. The beds were very springy and bouncy. Not super comfortable. There ...

Reviewed on Mar 5, 2026

Opens in a new windowAmericas Best Value Inn Medical Center Downtown
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl

2.5 out of 5
1301 Braeswood Blvd Houston TX
Fully refundableReserve now, pay when you stay
The price is CA $106 per night from Mar 30 to Mar 31
CA $106
CA $124 total
Mar 30 - Mar 31
includes taxes & fees
Book a stay at this business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
Staff and parking were good. Room 322 needs much attention. The bathroom floor is peeling up and the door lock really didn’t work well. My husband put a chair under the door knob to secure the door. Bed was comfortable but carpet looked nasty.

Reviewed on Mar 5, 2026

Opens in a new windowExtended Stay America Suites Houston Med Ctr Braeswood Bl
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