
Book Cheap American Airlines flight from Buffalo (BUF) to Key West (EYW) from CA $317
Find The Best Day to Book a Cheap American Airlines Flights From Buffalo to Key West
Cheapest American Airlines Flights from Buffalo (BUF) to Key West (EYW)
The cheapest flights to Key West Intl. found within the past 7 days were CA $473 round trip and CA $317 one way. Prices and availability subject to change. Additional terms may apply.
EYW From BUF Economy Coach Packages on Similar Airlines



Frequently asked questions
Grab a great American Airlines flight from BUF to EYW
To find a great deal on American Airlines flights with Travelocity, simply enter your origin and destination airports, pick your travel dates, and hit search. From here, you can sort by price, flight duration, and arrival/departure time. You can also filter to find nonstop flights.
Flying American Airlines Buffalo to Key West gives you fights to choose from. With that direct flight time of , you’ll be touching down before you know it.
Find cheap flights with American Airlines between Buffalo and Key West
American Airlines has a range of great fares on stacks of flights, and to find the most affordable for you, there are a few tricks you can try. Booking in advance, for example, is a great way to grab a fantastic deal. Also, choose the cheapest month, if you can. One-way flights from Buffalo to Key West with American Airlines are March.
The more flexible you are, the more affordable flights you’re likely to find. Consider one-way flights and connecting flights, as well as standard roundtrip and direct options. Even if you’re flying today, cheap last-minute flights are easy to find by entering your travel dates and hitting search.
Reasons to book your American Airlines flights with Travelocity
Travelocity makes it easy to book a seat, anywhere in the world. The vast inventory, fast search, and advanced filters put some of the best deals on the planet in one place. Whether you’re traveling on business, with friends, family, or on your own, take your pick from some fantastic options. And with free cancellation and pay later options, you can travel more and worry less.
Airport code | Country | Airport name | Number of flights |
|---|---|---|---|
| DFW | USA | Dallas-Fort Worth Intl. | 599 |
| CLT | USA | Charlotte-Douglas Intl. | 536 |
| ORD | USA | O'Hare Intl. | 317 |
| PHL | USA | Philadelphia Intl. | 247 |
| MIA | USA | Miami Intl. | 193 |
| DCA | USA | Ronald Reagan Washington National | 152 |
| PHX | USA | Sky Harbor Intl. | 141 |
| LAX | USA | Los Angeles Intl. | 81 |
| LGA | USA | LaGuardia | 72 |
| BOS | USA | Logan Intl. | 57 |
Travelers ❤️ these 🏨 after their flight to Key West

Hyatt Vacation Club at Windward Pointe, Key West
Great view, clean property. Beds were very comfortable. Having a telescope to view the stars is a nice touch
Reviewed on Jan 16, 2026

Hampton Inn Key West FL
The staff is excellent especially Sam who always helps me when I stay there.
Reviewed on Jan 16, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Great Place
Reviewed on Jan 19, 2026
Want more than a(n) American Airlines Flight from Buffalo to Key West?
Popular American Airlines Flight Routes from BUF
Domestic
- Montreal to Miami (YUL - MIA)
- Toronto to Delhi (YYZ - DEL)
- Toronto to Colombo (YYZ - CMB)
- Montreal to Orlando (YUL - MCO)
- Montreal to Las Vegas (YUL - LAS)
- Toronto to London (YYZ - LHR)
- Toronto to Orlando (YYZ - MCO)
- Toronto to Montego Bay (YYZ - MBJ)
- Toronto to Miami (YYZ - MIA)
- Toronto to Tokyo (YYZ - HND)
International
- Toronto to Delhi (YYZ - DEL)
- Montreal to Las Vegas (YUL - LAS)
- Montreal to Orlando (YUL - MCO)
- Toronto to Las Vegas (YYZ - LAS)
- Toronto to Montego Bay (YYZ - MBJ)
- Toronto to Tokyo (YYZ - HND)
- Toronto to Montego Bay (YYZ - MBJ)
- Toronto to Mumbai (YYZ - BOM)
- Toronto to Punta Cana (YYZ - PUJ)
- Toronto to Karachi (YYZ - KHI)
Most Popular
- Toronto to Orlando (YYZ - MCO)
- Swoop Hamilton (YHM) to St. Petersburg - Clearwater (PIE) flights
- WestJet Edmonton (YEG) to Orlando (MCO) flights
- Montreal to Fort Lauderdale (YUL - FLL)
- Toronto to Sarasota (YYZ - SRQ)
- Toronto to Tampa (YYZ - TPA)
- Detroit to Orlando (DTW - MCO)
- New York to Toronto (JFK - YYZ)
- Buffalo to New York (BUF - JFK)
- Toronto to St. Petersburg (YYZ - PIE)
- Air Canada Toronto (YYZ) to Orlando (MCO) flights
- Toronto to Miami (YYZ - MIA)
- Toronto to New York (YYZ - JFK)
- Toronto to Fort Myers (YYZ - RSW)
- Fort Lauderdale to Toronto (FLL - YYZ)
- JetBlue Airways Buffalo (BUF) to Fort Lauderdale (FLL) flights
- Buffalo to Orlando (BUF - MCO)
- Swoop Hamilton (YHM) to Sanford (SFB) flights
- Orlando to Toronto (MCO - YYZ)
- Halifax to Orlando (YHZ - MCO)
- Vancouver to Orlando (YVR - MCO)
- Air Canada Montreal (YUL) to Orlando (MCO) flights
- Detroit to Tampa (DTW - TPA)
- Toronto to New York (YYZ - LGA)
- St. John's to Orlando (YYT - MCO)
- Air Canada Toronto (YYZ) to Fort Lauderdale (FLL) flights
- Flair Airlines Toronto (YYZ) to Miami (MIA) flights
- Vancouver to New York (YVR - JFK)
- Detroit to Miami (DTW - MIA)
- Toronto to Panama City (YYZ - ECP)
