Eastern Panama Vacations 2025/2026 from CA $1,298

Eastern Panama flight + hotel packages

Price found within the past 48 hours. Click for updated prices.

Megapolis Hotel Panamá

Punta Paitilla

CA $1,298

per person

Nov 15 - Nov 22

found 1 day ago

Roundtrip flight included

Edmonton (YEG) to Panama City (PTY)

Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Central Hotel Panama Casco Viejo

Casco Viejo

CA $1,903

per person

Nov 15 - Nov 22

found 1 day ago

Roundtrip flight included

Edmonton (YEG) to Panama City (PTY)

Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Casa Fofo Family House

CA $1,873

per person

Nov 16 - Nov 23

found 7 hours ago

Roundtrip non-stop flight included

Edmonton (YEG) to Panama City (PTY)

Stay at this 3-star guesthouse in San Carlos. Enjoy free WiFi, free parking, and private pools. Popular attractions Playa El Palmar and Teta Beach are located nearby.

La Coralina Island House

CA $1,875

per person

Nov 16 - Nov 23

found 7 hours ago

Roundtrip non-stop flight included

Edmonton (YEG) to Panama City (PTY)

Stay at this 3.5-star beach hotel in Bocas del Toro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Paunch Beach and Tortuga Beach are located nearby.

La Concordia Boutique Hotel

Casco Viejo

CA $2,128

per person

Nov 15 - Nov 22

found 1 day ago

Roundtrip flight included

Edmonton (YEG) to Panama City (PTY)

Stay at this 4-star family-friendly hotel in Panama City. Enjoy free WiFi, a rooftop terrace, and onsite spa services. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Top Eastern Panama hotels deals

Hotel Cocotal

La Guaira, Isla Grande, Provincia de Colón

Free cancellation

Reserve now, pay when you stay

CA $68

CA $136 total

Sep 14 - Sep 15

includes taxes & fees

Stay at this hotel in Isla Grande. Enjoy free breakfast, free WiFi, and 20 restaurants. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

Breakfast included

Pet-friendly

Ciel y Miel

Caillle Principale, Cacique, Provincia de Colón

Get rates

Stay at this 3-star beach hotel in Cacique. Enjoy free breakfast, free WiFi, and free valet parking. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

Pool

Breakfast included

Ordovician Beach Resort

Isla Grande, Isla Grande, Colon

Get rates

Stay at this 4.5-star luxury resort in Isla Grande. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

On private beach

Pool

San Blas Paradise Private Cabins on Shipwreck Island - meals included

Perro Island, Narganá, Guna Yala

Get rates

Book a stay at this beach hotel in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Diablo and Isla Chichime are located nearby.

Breakfast included

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island, Narganá, Guna Yala

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Stay at this hotel in San Blas Islands. Enjoy free breakfast, an airport shuttle (surcharge), and a garden. Popular attractions Isla Diablo and Isla Chichime are located nearby.

Breakfast included

Restaurant

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

Get rates

Book a stay at this beach villa in Palenque. Enjoy free WiFi, a beach locale, and breakfast (surcharge).

Kitchen

Washer

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Isla Diablo

Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area.

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Masargantupo. Stroll along the seaside or experience the area's festivals.

Isla Chichime

Commune with nature and explore the great outdoors at Isla Chichime during your travels in San Blas Islands. Take in the festivals while you're in the area.

Frequently asked questions

How much are vacation packages to Eastern Panama?

Exciting adventures await in Eastern Panama, with Travelocity vacation packages starting from as low as CA $1,298. Including flights and hotels, these awesome deals make it a breeze to see more of our beautiful planet.

Where can I get the best vacation package deals for Eastern Panama?

You can snap up amazing Eastern Panama package deals with Travelocity. Mix and match from 400 air carriers and 1,000,000 worldwide properties and turn those travel dreams into a reality.

Why should I purchase my Eastern Panama vacation package with Travelocity?

We offer 24/7 support, top-quality service and a Price Match Guarantee. Life's a great big journey — and we have alluring destinations for you to journey to all across the world. Wander with us and your wallet will thank you for it.

Can I save money on my Eastern Panama car rental if I bundle it with my hotel or flight?

Certainly. And our Eastern Panama vacation packages are the perfect way to do it. In just a few clicks you can save cash as well as time by bundling your bookings. Pick up the keys to your rental car and feel the freedom of the open road. Searching for things to do? Add some tours or experiences to your package and make savings on those too.

What is there to do in Eastern Panama?

You'll be happy to know Eastern Panama is brimming with incredible things to see and do, however Isla Mamey and Cayos Holandeses are right up there with the very best.