Eastern Panama Vacations 2025/2026 from CA $1,254

Eastern Panama flight + hotel packages

Price found within the past 48 hours. Click for updated prices.

Villa Botero By Casa Mojito B&B

CA $1,254

per person

Jan 10 - Jan 17

found 1 day ago

Roundtrip non-stop flight included

Detroit (DTW) to Panama City (PTY)

Stay at this 3-star golf B&B in Rio Hato. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Playa Blanca and Farallón Beach are located nearby.

Ciel y Miel

CA $1,548

per person

Jan 12 - Jan 17

found 18 hours ago

Roundtrip non-stop flight included

Toronto (YTO) to Panama City (PTY)

Stay at this 3-star beach hotel in Cacique. Enjoy free breakfast, free WiFi, and free valet parking. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

Mahogany Suites

CA $1,719

per person

Dec 29 - Jan 5

found 1 day ago

Roundtrip non-stop flight included

Toronto (YTO) to Panama City (PTY)

Book a stay at this golf hotel in Arraijan. Enjoy free WiFi, a golf course, and an outdoor pool. Popular attractions Albrook Shopping Mall and Amador Causeway are located nearby.

Central Hotel Panama Casco Viejo

Casco Viejo

CA $2,666

per person

Dec 20 - Dec 27

found 1 day ago

Roundtrip flight included

Toronto (YTO) to Panama City (PTY)

Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Casa Fofo Family House

CA $1,730

per person

Jan 21 - Jan 27

just found

Roundtrip non-stop flight included

Toronto (YTO) to Panama City (PTY)

Stay at this 3-star guesthouse in San Carlos. Enjoy free WiFi, free parking, and private pools. Popular attractions Playa La Ensenada and Playa El Palmar are located nearby.

Top Eastern Panama hotels deals

Ranchos de Chalia

Portobelo via Puerto Lindo, Unit 3, Puerto Lindo, Colón

CA $159

CA $176 total

Nov 27 - Nov 28

includes taxes & fees

Stay at this 3-star hotel in Puerto Lindo. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

Pool

Breakfast included

HOTEL ISLA GRANDE

Final de paseo La Punta Isla Grande, 01, Isla Grande, Colón Province

Free cancellation

Reserve now, pay when you stay

CA $147

CA $161 total

Nov 11 - Nov 12

includes taxes & fees

Stay at this 3-star beach hotel in Isla Grande. Enjoy free breakfast, a beach locale, and onsite spa services. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

Ordovician Beach Resort

Isla Grande, Isla Grande, Colon

Get rates

Stay at this 4.5-star luxury resort in Isla Grande. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

Ciel y Miel

Caillle Principale, Cacique, Provincia de Colón

Get rates

Stay at this 3-star beach hotel in Cacique. Enjoy free breakfast, free WiFi, and free valet parking. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

Hotel Cocotal

La Guaira, Isla Grande, Provincia de Colón

Free cancellation

Reserve now, pay when you stay

CA $52

CA $120 total

Nov 24 - Nov 25

includes taxes & fees

Stay at this hotel in Isla Grande. Enjoy free breakfast, free WiFi, and 20 restaurants. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

Breakfast included

Pet-friendly

San Blas Paradise Private Cabins on Shipwreck Island - meals included

Perro Island, Narganá, Guna Yala

Get rates

Book a stay at this beach hotel in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Diablo and Isla Chichime are located nearby.

Breakfast included

Don't see what you're looking for?

See all available properties in Eastern Panama

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Isla Diablo

Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area.

Isla Chichime

Commune with nature and explore the great outdoors at Isla Chichime during your travels in San Blas Islands. Take in the festivals while you're in the area.

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Narganá. Stroll along the seaside or experience the area's festivals.

Frequently asked questions

How much are vacation packages to Eastern Panama?

Exciting adventures await in Eastern Panama, with Travelocity vacation packages starting from as low as CA $1,254. Including flights and hotels, these awesome deals make it a breeze to see more of our beautiful planet.

Where can I get the best vacation package deals for Eastern Panama?

You can snap up amazing Eastern Panama package deals with Travelocity. Mix and match from 400 air carriers and 1,000,000 worldwide properties and turn those travel dreams into a reality.

Why should I purchase my Eastern Panama vacation package with Travelocity?

We offer 24/7 support, top-quality service and a Price Match Guarantee. Life's a great big journey — and we have alluring destinations for you to journey to all across the world. Wander with us and your wallet will thank you for it.

Can I save money on my Eastern Panama car rental if I bundle it with my hotel or flight?

Certainly. And our Eastern Panama vacation packages are the perfect way to do it. In just a few clicks you can save cash as well as time by bundling your bookings. Pick up the keys to your rental car and feel the freedom of the open road. Searching for things to do? Add some tours or experiences to your package and make savings on those too.

What is there to do in Eastern Panama?

You'll be happy to know Eastern Panama is brimming with incredible things to see and do, however Isla Mamey and Cayos Holandeses are right up there with the very best.