Book spa resorts in Eastern South Dakota, SD from CA $75
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Top Eastern South Dakota Spa Resorts & Hotels

Fairfield Inn & Suites Sioux Falls Airport
4035 Bobhalla Drive Sioux Falls SD
Free cancellation
Reserve now, pay when you stay
The price is CA $150 per night
CA $150
CA $168 total
Dec 14 - Dec 15
includes taxes & fees
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...

Hampton Inn Sioux Falls
2417 S Carolyn Ave Sioux Falls SD
Free cancellation
Reserve now, pay when you stay
The price is CA $135 per night
CA $135
CA $150 total
Jan 2 - Jan 3, 2026
includes taxes & fees
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

Staybridge Suites Sioux Falls by IHG
2505 S Carolyn Ave Sioux Falls SD
Free cancellation
The price is CA $134 per night
CA $134
CA $150 total
Dec 14 - Dec 15
includes taxes & fees
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

La Quinta Inn & Suites by Wyndham Sioux Falls
4521 W. 41st Street Sioux Falls SD
Free cancellation
Reserve now, pay when you stay
The price is CA $115 per night
CA $115
CA $129 total
Dec 14 - Dec 15
includes taxes & fees
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG
2501 S Shirley Ave Sioux Falls SD
Free cancellation
The price is CA $180 per night
CA $180
CA $200 total
Dec 13 - Dec 14
includes taxes & fees
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...

AmericInn by Wyndham Aberdeen - Event Center
301 Centennial St Aberdeen SD
Free cancellation
Reserve now, pay when you stay
The price is CA $164 per night
CA $164
CA $181 total
Dec 25 - Dec 26
includes taxes & fees
Book a stay at this business-friendly hotel in Aberdeen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

Holiday Inn Sioux Falls-City Centre by IHG
100 W 8th St Sioux Falls SD
Free cancellation
The price is CA $125 per night
CA $125
CA $140 total
Dec 21 - Dec 22
includes taxes & fees
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy breakfast (surcharge), a free airport shuttle, and room service. Our guests praise the helpful ...

AmericInn by Wyndham Mitchell
1421 South Burr Street Mitchell SD
Free cancellation
Reserve now, pay when you stay
The price is CA $135 per night
CA $135
CA $149 total
Dec 17 - Dec 18
includes taxes & fees
Stay at this hotel in Mitchell. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...

Best Western Kelly Inn
1607 E Highway 50 Yankton SD
Free cancellation
Reserve now, pay when you stay
The price is CA $135 per night
CA $135
CA $150 total
Dec 28 - Dec 29
includes taxes & fees
Book a stay at this business-friendly hotel in Yankton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...

Best Western Of Huron
2000 Dakota Ave S Huron SD
Stay at this hotel in Huron. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Prospect ...

Quality Inn & Suites Sioux Falls South
3216 S Carolyn Ave Sioux Falls SD
Free cancellation
Reserve now, pay when you stay
The price is CA $76 per night
CA $76
CA $86 total
Dec 12 - Dec 13
includes taxes & fees
Stay at this hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

Ramada by Wyndham Sioux Falls
407 South Lyons Avenue Sioux Falls SD
Free cancellation
Reserve now, pay when you stay
The price is CA $66 per night
CA $66
CA $75 total
Jan 11 - Jan 12, 2026
includes taxes & fees
Stay at this hotel in Sioux Falls. Enjoy free breakfast, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...
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See all available properties in Eastern South Dakota
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
About Eastern South Dakota Spa Hotels
There is nothing more refreshing than a day at the spa. And the pure joy of spa hotels in Eastern South Dakota will make you feel rejuvenated and relaxed. Pamper yourself while in Eastern South Dakota with a massage, a calming facial, or relaxation in the sauna or steam room. Spa hotels in Eastern South Dakota offer everything you need to feel ultimate tranquility. So book today on Travelocity to find deals on Eastern South Dakota spa hotel and prepare to relax.
Eastern South Dakota hotels essential information
Accommodation | 901 hotels |
|---|---|
Lowest Price | CA $75 |
Highest Price | CA $200 |
Popular hotels | Hampton Inn Sioux Falls, La Quinta Inn & Suites by Wyndham Sioux Falls, Holiday Inn Sioux Falls-City Centre by IHG, Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG, Fairfield Inn & Suites Sioux Falls Airport, Quality Inn & Suites Sioux Falls South, Staybridge Suites Sioux Falls by IHG, Ramada by Wyndham Sioux Falls, AmericInn by Wyndham Aberdeen - Event Center, AmericInn by Wyndham Mitchell, Best Western Kelly Inn, Best Western Of Huron |
Recent Eastern South Dakota hotel reviews by fellow wanderers

La Quinta Inn & Suites by Wyndham Sioux Falls
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Everything was great!! Clean rooms and great staff!!!"
A verified traveller stayed at La Quinta Inn & Suites by Wyndham Sioux Falls
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