See all properties

Hilton Jacksonville At Mayo Clinic

4.5 star property
4.5-star luxury hotel near Mayo Clinic Florida

Choose dates to view prices

Photo gallery for Hilton Jacksonville At Mayo Clinic

Breakfast, lunch, dinner served; American cuisine
Lobby
Lobby
Terrace/patio
Lake view

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Pool
  • Parking included
  • Free WiFi
  • Restaurant
  • Air conditioning
  • Gym

Explore the area

View in a map
4745 Transformation Way, Jacksonville, FL, 32224
  • Place, Mayo Clinic Florida
    ‪1 min walk‬
  • Place, St. Johns Town Center
    ‪7 min drive‬
  • Place, Mayport Naval Station
    ‪17 min drive‬
  • Airport, Jacksonville, FL (JAX-Jacksonville Intl.)
    ‪32 min drive‬

Room options

View all photos for Room, 1 King Bed

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed

9.0 out of 10
Wonderful
(2 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed (Water View)

View from room

Deluxe Room, 1 King Bed (Water View)

  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

View from room

Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Corner

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Corner

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Zero Count)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Zero Count)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View)

9.0 out of 10
Wonderful
(2 reviews)
  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View, Roll-In Shower)

  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Roll-In Shower)

Room, 1 King Bed, Accessible (Roll-In Shower)

Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 2 Queen Beds

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds

9.6 out of 10
Exceptional
(21 reviews)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Water View, Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Water View, Hearing)

  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub

10.0 out of 10
Exceptional
(1 review)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Hearing)

8.0 out of 10
Very good
(1 review)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds (Water View)

10.0 out of 10
Exceptional
(1 review)
  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub (View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub (View)

  • Sleeps 4
  • 2 Queen Beds

You may also like

Ad
Lobby

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Palm Valley
  • Pool
  • Hot tub
  • Pet friendly
  • Free WiFi
4.6 out of 5, Wonderful, 1,022 reviews
The price is CA $212
CA $236 total
includes taxes & fees
Mar 17 - Mar 18
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

About the area

Jacksonville

In Jacksonville .At this Jacksonville hotel, you'll be within half a mile (1 km) of Mayo Clinic Florida and 3 miles (5 km) of Harbor City Municipal Golf Course. Windsor Commons Shopping Center and Windsor Parke Golf Club are also within 6 miles (10 km).

What's nearby

  • Mayo Clinic Florida - 1 min walk - 0.0 km
  • University of North Florida - 5 min drive - 8.3 km
  • St. Johns Town Center - 7 min drive - 10.9 km
  • TPC Sawgrass - 12 min drive - 14.7 km
  • Mayport Naval Station - 17 min drive - 18.9 km

Getting around

  • Jacksonville Station - 28 min drive
  • Jacksonville International Airport (JAX) - 33 min drive

Restaurants

  • ‪Culver’s - ‬3 min drive
  • ‪Starbucks - ‬3 min drive
  • ‪Circle K - ‬16 min walk
  • ‪M Brothers at Mayo - ‬14 min walk
  • ‪Starbucks - ‬13 min walk

About this property

Hilton Jacksonville At Mayo Clinic

4.5-star luxury hotel near Mayo Clinic Florida
Hilton Jacksonville At Mayo Clinic offers its guests an outdoor pool and a fitness center. There's a restaurant on site. You can enjoy a drink at the bar/lounge. Public spaces have free WiFi.

Business amenities include 12 meeting rooms and coworking spaces. Event space at this hotel measures 20000 square feet (1858 square meters) and includes conference space. The luxury Hilton Jacksonville At Mayo Clinic also features concierge services, laundry facilities, and dry cleaning/laundry services. A free area shuttle within 350 yards is available. Self parking is free.

This 4.5-star Jacksonville hotel is smoke free.

  • 1 building
  • 252 guestrooms or units
  • 8 levels
  • Meeting rooms
  • 20000 sq ft of conference space
  • 1858 sq m of conference space
  • Built in 2025
  • Poolside lounge chairs
  • Umbrellas for the pool
  • Charging station for electric cars
  • Conference space
  • Breakfast available (surcharge)
  • Dry cleaning
  • Self-service laundry
  • Front desk (24 hours)
  • Express check-out
  • Storage area for luggage
  • Concierge
  • Wedding services available
  • Convenience store
  • Television in lobby
  • Bellhop
  • No smoking on site
  • Bar or lounge
  • Dining venue
Hilton Jacksonville At Mayo Clinic offers 252 air-conditioned accommodations with laptop-compatible safes and complimentary bottled water. Beds feature premium bedding. 55-inch Smart televisions come with premium cable channels and Netflix. Bathrooms include bathtubs or showers and hair dryers.

Guests can surf the web using the complimentary wireless Internet access (speed: 25+ Mbps). Business-friendly amenities include phones; local and long-distance calls are complimentary (restrictions may apply). Additionally, rooms include coffee/tea makers and irons/ironing boards. Housekeeping is provided daily.

Similar properties

Exterior
Hyatt Regency Jacksonville
  • Pool
  • Pet friendly
  • Free WiFi
  • Restaurant
4.5 out of 5, Wonderful, 1,506 reviews
The price is CA $290
CA $332 total
includes taxes & fees
Mar 2 - Mar 3
Hyatt Regency Jacksonville

Property amenities

Family friendly

  • Free area shuttle
  • Grocery/convenience store
  • In-room crib
  • Laundry facilities
  • Mini-fridge
  • Outdoor pool
  • Rollaway/extra bed (surcharge)

Internet

  • Available in all rooms: Free WiFi
  • In-room WiFi speed: 25+ Mbps
  • Available in some public areas: Free WiFi

Parking and transportation

  • Electric car charging station on site
  • Free area shuttle up to 350 yds
  • Free uncovered self parking on site

Food and drink

  • Daily buffet breakfast available 6:00 AM to 10:30 AM for a fee: USD 26.99 to 26.99 for adults and USD 15 to 21 for children
  • A bar/lounge
  • A restaurant

Things to do

  • Gym
  • Outdoor pool
  • TV in common areas

Accessibility

  • Tile flooring in public areas

Room amenities

Entertainment

  • 55-inch smart TV with premium cable channels
  • Netflix
  • Streaming services

Bedroom

  • Blackout drapes
  • Free crib
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathtub or shower
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Food and drink

  • Coffee/tea maker
  • Free bottled water
  • Late-night room service
  • Mini-fridge

More

  • Air conditioning
  • Free local calls
  • Free long-distance calls
  • Heating
  • Iron/ironing board
  • Laptop-compatible safe
  • LED lighting
  • Mobile key entry
  • Phone
  • Recycling
  • Water-efficient showers
  • Water-efficient toilets

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 5:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM
Contactless check-out available
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
The credit card used to book the reservation must be presented by the cardholder at check-in along with matching photo identification, and other arrangements must be coordinated with the property prior to arrival
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • No pets allowed

Children and extra beds

  • Children are welcome.
  • Kids stay free! Up to 2 children 18 years old and younger stay free, per registered adult, when using existing bedding.
  • Rollaway/extra beds are available for USD 50.00 per night.
  • Free cribs (infant beds)!

Property payment types

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Breakage deposit: USD 100 per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for buffet breakfast: approximately USD 26.99 to 26.99 for adults, and USD 15 to 21 for children
  • Rollaway bed fee: USD 50.00 per night

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards and debit cards; cash is not accepted
This property reserves the right to pre-authorize the guest's credit card prior to arrival.
Cashless transactions are available
Safety features at this property include a carbon monoxide detector and a smoke detector
Charges for extra guests may apply and vary according to property policy.
A credit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation. This property accepts Visa, Mastercard, American Express, Discover, Diners Club, Carte Blanche, and debit cards. Cash is not accepted. This property reserves the right to pre-authorize the guest's credit card prior to arrival.
    For guests' safety, the property includes a carbon monoxide detector and a smoke detector in each accommodation. Cashless payment methods are available for all transactions and guests can access their rooms with a mobile device.

We should mention

  • Pool access available from 8:00 AM to 10:00 PM.
  • Up to 2 children 18 years old and younger stay free, per registered adult, in the same room as the parent or guardian when using existing bedding.
  • Registered guests are the only ones allowed to be in guestrooms.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

Hilton Jacksonville At Mayo Clinic Hotel
Hilton Jacksonville At Mayo Clinic Jacksonville
Hilton Jacksonville At Mayo Clinic Hotel Jacksonville

Hilton Jacksonville At Mayo Clinic Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 128 out of 152 reviews
Rating 8 - Good. 12 out of 152 reviews
Rating 6 - Okay. 5 out of 152 reviews
Rating 4 - Poor. 4 out of 152 reviews
Rating 2 - Terrible. 3 out of 152 reviews

9.8/10

Cleanliness

9.8/10

Staff & service

9.6/10

Amenities

10/10

Property conditions & facilities

Reviews

10/10 Excellent

Daisy

Liked: Cleanliness, amenities, property conditions & facilities
Loved this hotel! Great location - friendly staff- yummy food and drinks at Coastal restaurant- hire and rooms are so nice and clean - pool and gym area were a plus! Coffee spot and shuttle also nice to have available.
Stayed 3 nights in Jan 2026

10/10 Excellent

Shirley

Stayed 5 nights in Dec 2025

10/10 Excellent

Jo, Brunswick

Business traveller, Travelled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Everything was absolutely fantastic!!! Room, staff, decor, restaurant. Stayed here for an early procedure at Mayo Clinic, Jacksonville, FL.
Stayed 1 night in Nov 2025

10/10 Excellent

Linda

Liked: Cleanliness, staff & service, amenities
Every thing. The staff was phenomenal! The cleanliness was unsurpassed. I loved it. And, I felt safe and my automobile was in a safe location. I loved it!
Stayed 1 night in Nov 2025

10/10 Excellent

Christy

Stayed 2 nights in Oct 2025

10/10 Excellent

Majd, Friendswood

Stayed 2 nights in Nov 2025

6/10 Okay

Patrick

Business traveller, Travelled with partner
Liked: Cleanliness, property conditions & facilities
Nice hotel but Restaurant/Food is like gas station vending machines. Everything tastes frozen or mass produced. Yuck
Stayed 1 night in Nov 2025

10/10 Excellent

Joseph

Liked: Cleanliness, amenities, property conditions & facilities
We stayed at this newly opened hotel for three nights while I attended an appointment at the Mayo Clinic. The customer service was exceptional, and the property offers convenient amenities including an all-day restaurant, a heated pool, and shuttle service to and from the medical facilities. I highly recommend giving them a try
Stayed 2 nights in Nov 2025

2/10 Terrible

Barbara

Stayed 1 night in Nov 2025

10/10 Excellent

CAMPBELL

Stayed 1 night in Nov 2025

10/10 Excellent

Renee, Brunswick

Travelled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I booked this hotel after seeing it on TikTok and it ended up being the perfect staycation choice. The property is new, modern, and very clean. Our room was cozy with a beautiful view of both the sunset and sunrise. The bed was incredibly comfortable, and I loved the motion-sensor lights along the sides — such a thoughtful touch for nighttime. The bathroom was spacious, and the shower was a great size. The room also had an empty mini fridge (ideal for keeping drinks chilled) and a microwave for leftovers, which made the stay even more convenient. The gym was well-equipped with quality workout machines, much better than the typical hotel gym setup. I didn’t get a chance to check out the pool this time, but I definitely plan to when I return. Overall, this Hilton exceeded my expectations. Stylish, quiet, and comfortable — I’d absolutely stay here again.
Stayed 1 night in Nov 2025

10/10 Excellent

Shahriar, Fort Lee

Business traveller
Liked: Cleanliness, amenities, property conditions & facilities
This is by far the best Hilton in the country. Super modern, clean and classy. The room was also super nice, clean and spacious.
Stayed 1 night in Nov 2025

10/10 Excellent

Christine

Business traveller
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Gorgeous brand new hotel.
Stayed 2 nights in Oct 2025

10/10 Excellent

Donna

Business traveller
Went to Mayo Clinic. Wonderful place to stay.
Stayed 1 night in Nov 2025

10/10 Excellent

Shearn

Liked: Cleanliness, staff & service, property conditions & facilities
Very nice facility and staff. Would recommend to anyone visiting the Mayo Clinic.
Stayed 2 nights in Nov 2025

4/10 Poor

DeBora And Edward

Liked: Cleanliness, amenities
Disliked: Staff & service
Something else
Stayed 11 nights in Oct 2025

10/10 Excellent

Kamale

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Everything was great
Stayed 3 nights in Oct 2025

10/10 Excellent

EZEKIEL

Liked: Cleanliness, staff & service, amenities
Yes
Stayed 1 night in Oct 2025

10/10 Excellent

STEPHEN, Macon

Liked: Cleanliness, amenities, property conditions & facilities
Very very nice
Stayed 2 nights in Oct 2025

6/10 Okay

Michael

Travelled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The room was clean, but the bed and pillows were quite worn, and the thermostat wouldn’t go above 76°F. Other than that, everything else was fine and the stay was okay overall.
Stayed 3 nights in Oct 2025

10/10 Excellent

Matthew

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Oct 2025

10/10 Excellent

Joahnna, Ivins

Travelled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean, comfortable, nice restaurant & coffee shop.
Stayed 3 nights in Oct 2025

10/10 Excellent

Cathy

Liked: Cleanliness, staff & service, amenities
Room was spotless, new hotel, wonderful friendly staff
Stayed 1 night in Oct 2025

10/10 Excellent

DEBORAH

Liked: Cleanliness, staff & service, amenities
Spotless rooms, very friendly service!
Stayed 4 nights in Oct 2025

8/10 Good

juan

Stayed 2 nights in Oct 2025