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Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Property class: 3
3-star hotel near Mayo Clinic Florida

Choose dates to view prices

Photo gallery for Residence Inn By Marriott Jacksonville - Mayo Clinic Area

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.
A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.
A modern kitchen with a bar area, seating, and a view of the outdoors.
A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
4905 SAN PABLO ROAD SOUTH, Jacksonville, FL, 32224
  • Place, St. Johns Town Center
    ‪8 min drive‬
  • Place, EverBank Stadium
    ‪21 min drive‬
  • Place, Jacksonville Naval Air Station
    ‪29 min drive‬
  • Airport, Jacksonville, FL (JAX-Jacksonville Intl.)
    ‪34 min drive‬

Room options

View all photos for Studio, 1 King Bed with Sofa bed, Corner

A modern hotel room with a bed, desk, chair, TV, and large windows with curtains.

Studio, 1 King Bed with Sofa bed, Corner

9.8 out of 10
Exceptional
(6 reviews)
  • 50 sq m
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 Bedroom, Corner

A modern kitchen with wooden cabinets, a dishwasher, and a countertop with kitchenware. There is a dining area with a table and chairs, and a living room with a sofa and a TV on the wall.

Studio Suite, 1 Bedroom, Corner

10.0 out of 10
Exceptional
(4 reviews)
  • 60 sq m
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed

View all photos for Studio Suite, 1 King Bed with Sofa bed

A modern kitchen with wooden cabinets, a built-in microwave, and a dishwasher.

Studio Suite, 1 King Bed with Sofa bed

9.6 out of 10
Exceptional
(108 reviews)
  • 38 sq m
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 Bedroom

A modern hotel room with a grey sofa, a small round table, a desk with a chair, and a flat-screen TV mounted on the wall.

Studio Suite, 1 Bedroom

9.8 out of 10
Exceptional
(26 reviews)
  • 52 sq m
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed

View all photos for Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Tub)

A hotel room with a large bed, two bedside tables, and a nightstand with a phone.

Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Tub)

9.2 out of 10
Wonderful
(9 reviews)
  • 38 sq m
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 King Bed with Sofa bed (Hearing Accessible)

A hotel room with a large bed, two bedside tables, and a nightstand with a phone.

Studio Suite, 1 King Bed with Sofa bed (Hearing Accessible)

9.0 out of 10
Wonderful
(2 reviews)
  • 38 sq m
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Roll-In Shower)

A hotel room with a large bed, two bedside tables, and a nightstand with a phone.

Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Roll-In Shower)

10.0 out of 10
Exceptional
(1 review)
  • 38 sq m
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 Bedroom (Hearing Accessible)

A modern hotel room with a sofa, desk, and kitchenette.

Studio Suite, 1 Bedroom (Hearing Accessible)

8.0 out of 10
Very good
(1 review)
  • 52 sq m
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed

View all photos for Studio, 1 King Bed with Sofa bed, Corner (Hearing Accessible)

A modern hotel room with a bed, desk, chair, TV, and large windows with curtains.

Studio, 1 King Bed with Sofa bed, Corner (Hearing Accessible)

9.0 out of 10
Wonderful
(2 reviews)
  • 50 sq m
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 Bedroom, Corner (Mobility/Hearing Access, Roll-In Shwr)

A modern hotel room with a sofa, desk, and kitchenette.

Studio Suite, 1 Bedroom, Corner (Mobility/Hearing Access, Roll-In Shwr)

  • 60 sq m
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed

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About the area

Jacksonville

Isle of Palms stay.Within a 15-minute walk of this Isle of Palms hotel, you'll find Mayo Clinic Florida and Atlantic Intracoastal Waterway. Windsor Commons Shopping Center and Windsor Parke Golf Club are also within 6 miles (10 km).

What's nearby

  • St. Johns Town Center - 8 min drive - 12.6 km
  • Mayport Naval Station - 21 min drive - 18.6 km
  • EverBank Stadium - 21 min drive - 30.2 km
  • Jacksonville Naval Air Station - 29 min drive - 48.7 km
  • St. George Street - 42 min drive - 66.0 km

Getting around

  • Jacksonville, FL (CRG-Jacksonville Executive at Craig) - 17 min drive

Restaurants

  • ‪Culver’s - ‬4 min drive
  • ‪Circle K - ‬9 min walk
  • ‪Starbucks - ‬4 min drive
  • ‪Southern Grounds - ‬3 min drive
  • ‪Al's Pizza - ‬5 min drive

About this property

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3-star hotel near Mayo Clinic Florida
Residence Inn By Marriott Jacksonville - Mayo Clinic Area offers its guests an outdoor pool and a 24-hour fitness center. You can enjoy a drink at one of the bars, which include a poolside bar and a bar/lounge. Free breakfast is served daily. A computer station is on site and WiFi is free in public spaces.

A 24-hour business center, 2 meeting rooms, and coworking spaces are available. Event space at this hotel measures 2678 square feet (249 square meters) and includes conference space. Barbecue grills, multilingual staff, and a garden are also featured at the business-friendly Residence Inn By Marriott Jacksonville - Mayo Clinic Area. Self parking is free.

This 3-star Jacksonville hotel is smoke free.

  • 1 building
  • 155 guestrooms or units
  • 7 levels
  • 2678 sq ft of conference space
  • 249 sq m of conference space
  • Built in 2020
  • Buffet breakfast (free)
  • Poolside lounge chairs
  • Business center (24 hours)
  • Conference space
  • Coffee in lobby
  • Dry cleaning
  • Self-service laundry
  • Front desk (24 hours)
  • Express check-out
  • Staff is multilingual
  • Storage area for luggage
  • Front-desk safe
  • Concierge
  • Grocery service (free)
  • Wedding services available
  • Convenience store
  • Garden
  • BBQ grill(s)
  • Outdoor picnic space
  • Newspapers in lobby (free)
  • Fireplace in lobby
  • Television in lobby
  • Elevator
  • No smoking on site
  • Water dispenser
  • Bar or lounge
  • Bar by the pool
Residence Inn By Marriott Jacksonville - Mayo Clinic Area offers 155 air-conditioned accommodations with laptop-compatible safes and coffee/tea makers. Accommodations offer separate sitting areas. 55-inch Smart televisions come with premium cable channels and Netflix. Accommodations at this 3-star hotel have kitchens with refrigerators, stovetops, microwaves, and separate dining areas. Bathrooms include bathtubs or showers, complimentary toiletries, and hair dryers.

This Jacksonville hotel provides complimentary wireless Internet access. Business-friendly amenities include desks and phones. Additionally, rooms include irons/ironing boards and blackout drapes/curtains. Housekeeping is offered daily and change of bedsheets can be requested. Housekeeping is provided on request.

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Property amenities

Family friendly

  • Grocery/convenience store
  • In-room kitchen
  • In-room microwave
  • In-room refrigerator
  • Laundry facilities
  • Outdoor pool
  • Separate in-room dining area

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Free uncovered self parking on site
  • Wheelchair-accessible parking and van parking available

Food and drink

  • Free buffet breakfast available 6:30 AM to 9:00 AM on weekdays and 7:00 AM to 9:30 AM on weekends
  • A bar/lounge
  • A poolside bar
  • Coffee and tea in common areas

Things to do

  • 24-hour gym
  • Outdoor pool
  • TV in common areas

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Accessible bathtub
  • Assistive listening devices
  • Assistive listening devices in meeting rooms
  • Bathroom emergency pull cord
  • Braille/raised signage
  • Elevator
  • Grab bar near toilet
  • Hand-held showerhead
  • Handrails in stairways
  • Height-adjustable showerhead
  • Lever door handles
  • Low-height bed
  • Low-height counter and sink
  • Low-height door lock
  • Low-height electrical outlets in bathroom
  • Low-height view port in door
  • Phone accessibility kit
  • Pool hoist on site
  • Raised toilet seat
  • Stair-free path to entrance
  • Vibrating pillow alarm
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible business center
  • Wheelchair-accessible concierge desk
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible path to elevator
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible van parking
  • Wheelchair-width doorways

Room amenities

Entertainment

  • 55-inch smart TV with premium cable channels
  • Netflix
  • Streaming services

Bedroom

  • Bed sheets provided
  • Blackout drapes

Bathroom

  • Bathtub or shower
  • Free toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Food and drink

  • Coffee/tea maker
  • Cookware, dishware, and utensils
  • Dishwasher
  • Kitchen
  • Microwave
  • Refrigerator
  • Separate dining area
  • Stovetop
  • Toaster

More

  • Air conditioning
  • Connecting rooms available
  • Desk
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • Mobile key entry
  • Phone
  • Recycling
  • Separate sitting area
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 6:00 AM
Contactless check-in available
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM
Contactless check-out available
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • Pets: USD 150 per accommodation, per stay
  • Only dogs and cats are allowed
  • Maximum 2 (weight limit: 40 lbs per pet)
  • Restrictions apply
  • For more information, you can reach out to the property at the number on the booking confirmation
  • Service animals are exempt from fees

Children and extra beds

  • Children are welcome.
  • Cribs (infant beds) are not available.

Property payment types

  • American Express
  • Diners Club
  • Discover
  • Mastercard
  • Visa

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Deposit: USD 125 per accommodation, per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Pet fee: USD 150 per accommodation, per stay
  • Service animals are exempt from fees

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Cashless transactions are available
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, and window guards
Charges for extra guests may apply and vary according to property policy.
A cash deposit, credit card, or debit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. This property accepts Visa, Mastercard, American Express, Discover, and Diners Club. Cash is not accepted. For guests' safety, the property includes a carbon monoxide detector, a fire extinguisher, a smoke detector, and window guards in each accommodation. Cashless payment methods are available for all transactions and guests can access their rooms with a mobile device.

We should mention

  • Registered guests are the only ones allowed to be in guestrooms.
  • Connecting/adjoining rooms are subject to availability and can be requested by contacting the property at the number on your booking confirmation.
  • To make arrangements to bring your pet, contact the property directly at the number on your booking confirmation (please see the Fees section for related charges).
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

Residence INN BY Marriott Jacksonville
Residence Inn by Marriott Jacksonville East
Residence Inn Jacksonville Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic Area Hotel

Frequently asked questions

How close is Residence Inn By Marriott Jacksonville - Mayo Clinic Area to the airport?

Residence Inn By Marriott Jacksonville - Mayo Clinic Area is 11.2 mi (17-min drive) away from the Jacksonville, FL (CRG-Jacksonville Executive at Craig) airport, the closest popular airport to the property.

How much does it cost to stay at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

As of Nov 13, 2026, prices found for a 1-night stay for 2 adults at Residence Inn By Marriott Jacksonville - Mayo Clinic Area on Nov 20, 2026 start from CA $210, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area have an airport shuttle?

Airport shuttle services are not available at Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How close is Residence Inn By Marriott Jacksonville - Mayo Clinic Area to the beach?

This hotel is 4.4 mi (10-min drive) from Atlantic Beach and 5.4 mi (9-min drive) from Northeast Florida Beaches. Don't forget your sunscreen!

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area offer free breakfast?

Residence Inn By Marriott Jacksonville - Mayo Clinic Area offers free buffet breakfast on weekdays between 6:30 AM and 9:00 AM and weekends between 7:00 AM and 9:30 AM.

Is there a casino at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

No, there is no casino at this hotel.

What time is check-in at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Check-in start time: 4:00 PM; Check-in end time: 6:00 AM.

Is there free parking at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

This hotel offers free self parking.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area have a pool?

Residence Inn By Marriott Jacksonville - Mayo Clinic Area features an outdoor pool.

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area have a spa?

There are no spa services available at this hotel.

How close is Residence Inn By Marriott Jacksonville - Mayo Clinic Area to downtown Jacksonville?

Residence Inn By Marriott Jacksonville - Mayo Clinic Area is 14.1 mi away from Jacksonville.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 502 out of 623 reviews
Rating 8 - Good. 82 out of 623 reviews
Rating 6 - Okay. 15 out of 623 reviews
Rating 4 - Poor. 15 out of 623 reviews
Rating 2 - Terrible. 9 out of 623 reviews

9.6/10

Cleanliness

9.6/10

Staff & service

9.2/10

Amenities

9.6/10

Property conditions & facilities

Reviews

Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great stay
Stayed 1 night in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Our stay was short, but we truly enjoyed it, clean and breakfast was great!
Stayed 1 night in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great hotel, when traveling too the Jacksonville area this is my home away from home, I highly recommend this hotel.
Stayed 3 nights in May 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great and clean hotel and staff
Stayed 1 night in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The hotel was great had a great time
Stayed 2 nights in Jul 2026
Verified review

10/10 Excellent

Great place to stay!
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The room was clean and comfortable, and the front desk staff was very kind and helpful. Thank you for a wonderful stay!
Stayed 1 night in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I stayed at this hotel for 3 days. It was super clean and comfortable to stay the night for vacation.
Stayed 2 nights in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
My family stayed here. Clean hotel and great breakfast.
Stayed 1 night in Jun 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great prices for the rooms and amenities they come with. Best hotel breakfast Ive seen in a while- all the extras and more!
Stayed 2 nights in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great hotel with clean, comfortable rooms and friendly staff. The location was convenient, and the breakfast was delicious. Overall, we had a pleasant stay and would definitely recommend it.
Stayed 1 night in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very nice hotel, it even has kitchen, refri, desk. Super clean an quiet.
Stayed 1 night in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
This property was amazing! We will definitely stay here again!!
Stayed 1 night in Jun 2026
Verified review

10/10 Excellent

Liked: Cleanliness
Great room, breakfast was fantastic
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Well maintained and the staff extremely professional!!
Stayed 2 nights in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The entire hotel was excellent ! Staff , breakfast , clean room I would recommend this hotel .
Stayed 3 nights in May 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We love this hotel.. everything you need and more, great staff!!!
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
An amazing property, with very comfortable room and helpful staff. Complimentary breakfast is great!
Stayed 2 nights in May 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very clean facility. Suite was perfect for our family of 4. Gym was well-equipped.
Stayed 5 nights in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great clean hotel. The location is perfect for Mayo Clinic guests. Our bed was comfortable and the room is laid out very nicely with a small kitchen, full-size refrigerator, and a walk-in shower. We had dinner in the hotel bar area and it was very good. The staff is very funny.
Stayed 2 nights in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We stayed in one bedroom unit. The whole unit was super clean, the arrangement was super comfortable. Beds were super soft and I adore white sheets and blankets! The atmosphere was quite. Breakfast was aboundant and nutritious, lots of options.
Stayed 1 night in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room extremely clean, good staff, buffet breakfast and nice kitchen in studio room.
Stayed 2 nights in May 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities
Conveniently located, clean rooms, excellent breakfast
Stayed 2 nights in Jan 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities
We enjoyed our stay. Breakfast was good and stocked well. Love the proximity to Mayo Clinic.
Stayed 2 nights in May 2026
Verified review

10/10 Excellent

Great stay! Clean room, friendly staff.
Stayed 1 night in Jan 2026