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Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
Enjoy free breakfast at this spa Cape Girardeau hotel

Choose dates to view prices

Photo gallery for Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Exterior
Indoor pool, open 8 AM to 11 PM, sun loungers
Suite, 1 Bedroom (Feature)
Exterior
Free breakfast

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Free WiFi
  • Air conditioning

Explore the area

View in a map
3253 William Street, Cape Girardeau, MO, 63701
  • Place, Saint Francis Medical Center
    ‪6 min walk‬
  • Place, Southeast Missouri State University
    ‪6 min drive‬
  • Place, Century Casino & Hotel Cape Girardeau
    ‪8 min drive‬
  • Airport, Cape Girardeau, MO (CGI-Cape Girardeau Municipal)
    ‪5 min drive‬

Room options

View all photos for Suite, 2 Queen Beds, Accessible (Roll-In Shower)

Suite, 2 Queen Beds, Accessible (Roll-In Shower)

Suite, 2 Queen Beds, Accessible (Roll-In Shower)

8.0 out of 10
Very good
(6 reviews)
  • 37 sq m
  • 1 bedroom
  • Sleeps 6
  • 2 Queen Beds

View all photos for Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed, Accessible (Roll-In Shower)

9.4 out of 10
Exceptional
(6 reviews)
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed

9.6 out of 10
Exceptional
(34 reviews)
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 2 Queen Beds

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 2 Queen Beds

9.6 out of 10
Exceptional
(58 reviews)
  • 1 bedroom
  • Sleeps 6
  • 2 Queen Beds

View all photos for Suite, 2 Queen Beds, Accessible (Mobility)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 2 Queen Beds, Accessible (Mobility)

9.4 out of 10
Exceptional
(15 reviews)
  • 37 sq m
  • 1 bedroom
  • Sleeps 6
  • 2 Queen Beds

View all photos for Standard Room, 1 Queen Bed

Premium bedding, down comforters, pillowtop beds, in-room safe

Standard Room, 1 Queen Bed

9.2 out of 10
Wonderful
(5 reviews)
  • 37 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 Queen Bed

View all photos for Standard Room

Premium bedding, down comforters, pillowtop beds, in-room safe

Standard Room

8.4 out of 10
Very good
(5 reviews)
  • 37 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 Bedroom (Feature)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 Bedroom (Feature)

10.0 out of 10
Exceptional
(1 review)
  • 1 bedroom
  • Sleeps 2
  • 1 Queen Bed

View all photos for Suite, 1 King Bed, Accessible (Mobility)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed, Accessible (Mobility)

10.0 out of 10
Exceptional
(2 reviews)
  • Sleeps 2
  • 1 King Bed

About the area

Cape Girardeau

Near the airport.A stay at this hotel places you within half a mile (1 km) of Saint Francis Medical Center and 3 miles (5 km) of Saint Francis Healthcare System. Southeast Missouri Hospital and Cape Splash Family Aquatic Center are also within 3 miles (5 km).

What's nearby

  • Saint Francis Medical Center - 6 min walk - 0.6 km
  • Riverfront Bridge Park - 6 min drive - 7.0 km
  • Southeast Missouri State University - 6 min drive - 6.3 km
  • Century Casino & Hotel Cape Girardeau - 8 min drive - 9.4 km
  • Show Me Center - 9 min drive - 9.1 km

Getting around

  • Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 10 min drive

Restaurants

  • ‪Chick-fil-A - ‬7 min walk
  • ‪Rhodes - ‬20 min walk
  • ‪McDonald's - ‬10 min walk
  • ‪White Castle - ‬10 min walk
  • ‪Wings Etc. - ‬9 min walk

About this property

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Enjoy free breakfast at this spa Cape Girardeau hotel
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG offers its guests a full-service spa, an indoor pool, and a fitness center. Public spaces have free WiFi and wired Internet. A business center and a meeting room are available. Free breakfast is served. Event space at this hotel measures 118 square feet (11 square meters) and includes conference space. The business-friendly Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG also features a vending machine, complimentary newspapers in the lobby, and laundry facilities. Self parking is free.

This Cape Girardeau hotel is smoke free.

  • 1 building
  • 102 guestrooms or units
  • 4 levels
  • 118 sq ft of conference space
  • 11 sq m of conference space
  • Breakfast available (free)
  • Poolside lounge chairs
  • Business facilities
  • Conference space
  • Dry cleaning
  • Self-service laundry
  • Front desk (24 hours)
  • Storage area for luggage
  • Front-desk safe
  • Newspapers in lobby (free)
  • Bellhop
  • No smoking on site
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG offers 102 accommodations with safes and coffee/tea makers. Accommodations offer separate sitting areas. Pillowtop beds feature down comforters and premium bedding. A pillow menu is available. 52-inch flat-screen televisions come with premium cable channels. Bathrooms include complimentary toiletries and hair dryers.

Guests can surf the web using the complimentary wired and wireless Internet access. Business-friendly amenities include desks and phones; free local calls are provided (restrictions may apply). Housekeeping is provided daily.

Guests can indulge in a pampering treatment at the hotel's full-service spa.

Similar properties

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center
  • Pool
  • Hot tub
  • Breakfast included
  • Pet friendly
4.8 out of 5, Exceptional, 1,000 reviews
The price is CA $137
CA $155 total
includes taxes & fees
Mar 29 - Mar 30
Drury Plaza Hotel Cape Girardeau Conference Center

Property amenities

Family friendly

  • In-room microwave
  • Indoor pool
  • Laundry facilities
  • Mini-fridge

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transportation

  • Free self parking on site
  • Wheelchair-accessible parking available

Food and drink

  • Free breakfast available

Things to do

  • Full-service spa
  • Gym
  • Indoor pool

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible path to elevator

Room amenities

Entertainment

  • 52-inch flat-screen TV with premium cable channels

Bedroom

  • Down comforter
  • Pillow menu
  • Pillowtop mattress
  • Premium bedding

Bathroom

  • Free toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Food and drink

  • Coffee/tea maker
  • Microwave
  • Mini-fridge

More

  • Air conditioning (climate-controlled)
  • Connecting rooms available
  • Desk
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Separate sitting area

Policies

Check-in

Check-in start time: 3:00 PM; Check-in end time: anytime
Contactless check-in available
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • No pets allowed

Children and extra beds

  • Children are welcome.
  • Cribs (infant beds) are not available.

Property payment types

Important information

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Cashless transactions are available
Safety features at this property include a fire extinguisher and a smoke detector
This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG)
Charges for extra guests may apply and vary according to property policy.
A cash deposit, credit card, or debit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. This property accepts Visa, Mastercard, American Express, Discover, Diners Club, JCB International, and Carte Blanche. Cash is not accepted. For guests' safety, the property includes a fire extinguisher and a smoke detector in each accommodation. Cashless payment methods are available for all transactions. This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG).

We should mention

  • Pool access available from 8 AM to 11 PM.
  • Connecting/adjoining rooms are subject to availability and can be requested by contacting the property at the number on your booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

Holiday Inn Express Cape Girardeau I-55
Holiday Inn Express Hotel Cape Girardeau I-55
Holiday Inn Hotel I-55
Holiday Inn Express Hotel Suites Cape Girardeau I 55
Inn Express Cape Girarau I55
Holiday Inn Express Hotel Suites Cape Girardeau I 55
Holiday Inn Express Hotel Suites Cape Girardeau I 55 by IHG

Frequently asked questions

How close is Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG to the airport?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is 6.1 mi (10-min drive) away from the Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport, the closest popular airport to the property.

How much does it cost to stay at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

As of Mar 24, 2026, prices found for a 1-night stay for 2 adults at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG on Apr 5, 2026 start from CA $141, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG have an airport shuttle?

Airport shuttle services are not available at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG.

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG offer free breakfast?

Yes, Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG offers free breakfast.

Is there a casino at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

No, there is no casino at this hotel, but Century Casino & Hotel Cape Girardeau (8-min drive) is nearby.

What time is check-in at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

Check-in start time: 3:00 PM; Check-in end time: anytime.

Is there free parking at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

This hotel offers free self parking.

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG have a pool?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG features an indoor pool. Guests can enjoy pool access from 8 AM to 11 PM.

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG have a spa?

Yes, this hotel has a spa.

How close is Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG to downtown Cape Girardeau?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is 3.2 mi away from Cape Girardeau.

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 776 out of 1000 reviews
Rating 8 - Good. 151 out of 1000 reviews
Rating 6 - Okay. 39 out of 1000 reviews
Rating 4 - Poor. 16 out of 1000 reviews
Rating 2 - Terrible. 18 out of 1000 reviews

9.6/10

Cleanliness

9.6/10

Staff & service

9.2/10

Amenities

9.6/10

Property conditions & facilities

Reviews

10/10 Excellent

Mary Ellen

Stayed 1 night in Dec 2025

10/10 Excellent

Summer

Travelled with family, Travelled with group
Liked: Cleanliness, staff & service, amenities
It was amazing check in to check out
Stayed 1 night in Aug 2025

10/10 Excellent

Brian

Stayed 1 night in Nov 2025

10/10 Excellent

Brian

Travelled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly.
Stayed 1 night in Dec 2025

10/10 Excellent

Amie

Travelled with family, Travelled with group
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great customer service!! The people next to our room were very loud with children yelling amd running around all night.
Stayed 1 night in Nov 2025

10/10 Excellent

Erik

Travelled with family
Liked: Cleanliness, staff & service, amenities
The room was clean, the staff were friendly, and they gave out free cookies in the evening, not just breakfast in the morning.
Stayed 1 night in Nov 2025

10/10 Excellent

Nellie

Travelled with family and small children
Liked: Cleanliness, amenities, property conditions & facilities
Clean room and staff was very friendly.
Stayed 2 nights in Nov 2025

10/10 Excellent

Emily

Liked: Cleanliness, property conditions & facilities
Clean and easy check in
Stayed 1 night in Nov 2025

10/10 Excellent

Marcus

Travelled with family
Liked: Cleanliness, amenities, property conditions & facilities
Beautiful room, whirlpool bath, breakfast, staff
Stayed 1 night in Nov 2025

10/10 Excellent

John

Liked: Amenities
Room was prestine and the buffet was excellent!!
Stayed 1 night in Nov 2025

6/10 Okay

Scott

Liked: Cleanliness, staff & service, amenities
The room was nice and clean but located near an ice machine that clunked all night long. I would suggest asking about the location of your room and the ice machine. Nice place but less than ideal stay
Stayed 1 night in Nov 2025

10/10 Excellent

Ainsley

Liked: Cleanliness, amenities
Upon entering this luxurious property, it’s as if one has accidentally teleported and stumbled into the Lobby of an upscale Hotel in a metropolitan city! Very modern, beautiful and a clean line type of architecture. The bed was fabulously comfortable! Way to go to Staff and Manager!! You guys are doing a great job! Thank you for providing a spectacular space to allow me and my college bestie to create more priceless memories!!
Stayed 1 night in Nov 2025

10/10 Excellent

Scott

Liked: Cleanliness, staff & service, amenities
Great staff and clean
Stayed 1 night in Nov 2025

10/10 Excellent

Christina

Travelled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Fast, very friendly desk service. We were allowed to check in a little early, a big plus since we arrived at 2 for a wedding at 3!! We got down for breakfast 30 minutes before the end of closing and it was evident. But the pancakes were great! Thanks for everyone's service!
Stayed 1 night in Nov 2025

10/10 Excellent

Brandon

Stayed 1 night in Nov 2025

10/10 Excellent

Marianne

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Very nice with comfy bed. It’s a lovely area. We went to a brewery in town and had pizza, salad and a beer.
Stayed 1 night in Nov 2025

10/10 Excellent

Hollie

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great
Stayed 1 night in Oct 2025

10/10 Excellent

Connie

Travelled with family
Liked: Cleanliness, staff & service, amenities
Spacious room, clean, & comfy with everything we needed.
Stayed 1 night in Nov 2025

10/10 Excellent

Bryan

Travelled with family and small children, Travelled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Excellent place to stay.
Stayed 1 night in Nov 2025

2/10 Terrible

rick

Stayed 2 nights in Oct 2025

10/10 Excellent

Connie

Stayed 1 night in Oct 2025

6/10 Okay

Gene

Business traveller
Liked: Cleanliness, property conditions & facilities, room comfort
Didnt appreciate finding out upon checking in that the elevators were out of order and all they had was second floor. Couldnt they be upfront about this when booking? So questionable at this price range.
Stayed 1 night in Oct 2025

10/10 Excellent

Gerald

Travelled with family, Travelled with group
Liked: Cleanliness, property conditions & facilities, room comfort
We had a great overnight stay to see SEMO play TSU! The hotel was great! No issues whatsoever.
Stayed 1 night in Oct 2025

10/10 Excellent

Kim

Stayed 1 night in Oct 2025

10/10 Excellent

Vicki

Stayed 1 night in Oct 2025