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21C Museum Hotel St Louis

4.5 star property
4.5-star luxury hotel near St. Louis Union Station

Choose dates to view prices

Photo gallery for 21C Museum Hotel St Louis

Restaurant
Exterior
In-room safe, desk, laptop workspace, blackout drapes
Exterior
Massages

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, City Museum
    ‪5 min walk‬
  • Place, St. Louis Union Station
    ‪8 min walk‬
  • Place, Enterprise Center
    ‪8 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪20 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(112 reviews)
  • 29 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(35 reviews)
  • 39 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

View all photos for Room (Bunk Bed)

Room (Bunk Bed)

Room (Bunk Bed)

8.4 out of 10
Very good
(7 reviews)
  • 22 sq m
  • Sleeps 2
  • 1 Twin Bunk Bed
  • Free WiFi

View all photos for Loft, 2 Queen Beds

Loft, 2 Queen Beds

Loft, 2 Queen Beds

9.0 out of 10
Wonderful
(2 reviews)
  • 40 sq m
  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, Accessible (Accessible)

10.0 out of 10
Exceptional
(1 review)
  • 25 sq m
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C)

  • 104 sq m
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library)

  • City view
  • 68 sq m
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(2 reviews)
  • 51 sq m
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible

  • 36 sq m
  • Sleeps 4
  • 1 Double Bed
  • Free WiFi

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Suite, 1 Double Bed, Accessible

  • 48 sq m
  • Sleeps 2
  • 1 Double Bed
  • Free WiFi

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Exterior

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  • Free airport shuttle
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4.4 out of 5, Excellent, 1,007 reviews
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CA $218 total
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Jun 21 - Jun 22
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About the area

St. Louis

Heart of St. Louis.Within a 10-minute walk of this Downtown West hotel, you'll find St. Louis Union Station and City Museum. Also, Enterprise Center is within half a mile (1 km) and Busch Stadium is within 2 miles (3 km).

What's nearby

  • Washington Avenue Historic District - 2 min walk - 0.2 km
  • City Museum - 5 min walk - 0.4 km
  • St. Louis Union Station - 8 min walk - 0.7 km
  • Enterprise Center - 8 min walk - 0.7 km
  • St. Louis Aquarium at Union Station - 11 min walk - 1.0 km

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 24 min drive

Restaurants

  • ‪Budweiser Kiel Club - ‬6 min walk
  • ‪Imo's Pizza Headquarters & Retail Store - ‬7 min walk
  • ‪City Museum Rooftop Cafe - ‬5 min walk
  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪Blood & Sand - ‬2 min walk

About this property

21C Museum Hotel St Louis

4.5-star luxury hotel near St. Louis Union Station
21C Museum Hotel St Louis offers its guests an indoor pool, a steam room, and a fitness center. There's a restaurant on site, as well as a coffee shop/cafe. You can enjoy a drink at the bar/lounge. WiFi is free in public spaces.

Business amenities include a business center and meeting rooms. Spa services, a vending machine, and concierge services are also featured at the luxury 21C Museum Hotel St Louis . For a fee, parking is available.

This 4.5-star St. Louis hotel is smoke free.

  • 104 guestrooms or units
  • Meeting rooms
  • Business facilities
  • Breakfast available (surcharge)
  • Dry cleaning
  • Front desk (24 hours)
  • Storage area for luggage
  • Concierge
  • Pool or billiards table
  • ATM
  • Elevator
  • No smoking on site
  • Bar or lounge
  • Coffee shop
  • Dining venue
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and safes. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries, and hair dryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs, and phones. Additionally, rooms include complimentary bottled water and irons/ironing boards. Change of towels and change of bedsheets can be requested. Housekeeping is provided daily.

Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

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Hyatt Regency St. Louis at The Arch
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  • Pet friendly
  • Free WiFi
  • Restaurant
  • Air conditioning
4.3 out of 5, Excellent, 4,073 reviews
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CA $248 total
includes taxes & fees
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Property amenities

Family friendly

  • Indoor pool
  • Soundproofed rooms

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

Room amenities

Entertainment

  • Flat-screen TV with premium digital channels

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • Pets: USD 100 per accommodation, per stay
  • Only dogs are allowed
  • Service animals are exempt from fees

Children and extra beds

  • Children are welcome.
  • Rollaway/extra beds are not available.
  • Cribs (infant beds) are not available.

Property payment types

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Service fee: USD 5 per accommodation, per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector, and outdoor lighting
Charges for extra guests may apply and vary according to property policy.
A cash deposit, credit card, or debit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. This property accepts Visa, Mastercard, and American Express. Cash is not accepted. For guests' safety, the property includes a fire extinguisher, a smoke detector, and outdoor lighting in each accommodation.

We should mention

  • Reservations are needed for massage services. For reservations, contact the hotel before arrival using the contact information on the booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

How close is 21C Museum Hotel St Louis to the airport?

21C Museum Hotel St Louis is 18.4 mi (24-min drive) away from the St. Louis Lambert Intl. Airport (STL) airport, the closest popular airport to the property.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of Jun 3, 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on Jun 14, 2026 start from CA $211, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Does 21C Museum Hotel St Louis have an airport shuttle?

Airport shuttle services are not available at 21C Museum Hotel St Louis .

Does 21C Museum Hotel St Louis offer free breakfast?

Free breakfast isn’t provided at 21C Museum Hotel St Louis , but cooked-to-order breakfast is offered for a fee of between USD 10 and 25 per person. It's available every day from 6:30 AM to 1:00 PM.

Is there a casino at 21C Museum Hotel St Louis ?

No, there is no casino at this hotel, but Horseshoe St. Louis Casino (3-min drive) and Casino Queen (5-min drive) are nearby.

What time is check-in at 21C Museum Hotel St Louis ?

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM.

Is there free parking at 21C Museum Hotel St Louis ?

Free parking is not available at this hotel. Valet parking is available for USD 50 per day.

Does 21C Museum Hotel St Louis have a pool?

21C Museum Hotel St Louis features an indoor pool.

Does 21C Museum Hotel St Louis have a restaurant?

Yes, there is a restaurant on site.

Does 21C Museum Hotel St Louis have a spa?

This hotel doesn't have a spa, but it does offer massages.

How close is 21C Museum Hotel St Louis to downtown St. Louis?

21C Museum Hotel St Louis is 0.4 mi away from St. Louis.

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1318 out of 1876 reviews
Rating 8 - Good. 288 out of 1876 reviews
Rating 6 - Okay. 136 out of 1876 reviews
Rating 4 - Poor. 62 out of 1876 reviews
Rating 2 - Terrible. 72 out of 1876 reviews

9.2/10

Cleanliness

9.0/10

Staff & service

9.0/10

Amenities

9.2/10

Property conditions & facilities

Reviews

Verified

10/10 Excellent

Sarah

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room was clean and serviced daily. Hotel was lovely and well appointed.
Stayed 3 nights in Apr 2026
Verified

10/10 Excellent

Eric

Liked: Cleanliness, amenities, property conditions & facilities
Great place to stay. I recommend it and will stay again.
Stayed 1 night in Feb 2026
Verified

8/10 Good

Kristen

Liked: Cleanliness, staff & service, amenities
Friendly staff, beautiful atmosphere, modern finishes.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Barry

Liked: Cleanliness, amenities, property conditions & facilities
Great atmosphere, excellent room accommodations. Staff at the Idlewolf restaurant inside the hotel were great, and the happy hour is excellent for the modest price. Will be staying again soon!
Stayed 3 nights in Feb 2026
Verified

10/10 Excellent

Hanna

Liked: Cleanliness, staff & service, amenities
The one of the best hotels in stl
Stayed 2 nights in Oct 2025
Verified

10/10 Excellent

Robert

Liked: Cleanliness, amenities, property conditions & facilities
Great service. Would definitely stay again
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Kimbriel

Liked: Cleanliness, amenities, property conditions & facilities
Everything was great i can’t wait to stay again
Stayed 2 nights in Jan 2026
Verified

8/10 Good

Valerie

Liked: Staff & service, amenities
Nice room, the hot tub and steam room were fantastic. The staff were friendly and it was convenient to have coffee right downstairs.
Stayed 4 nights in Feb 2026
Verified

10/10 Excellent

anthony

Liked: Cleanliness, amenities, property conditions & facilities
Clean room and the hotel itself is just gorgeous.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Linda

Liked: Cleanliness, amenities, property conditions & facilities
Beautiful, unique hotel. Loved the esthetics and vibe of the entire building.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Christopher

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great service and vibe. The art exhibit on the second floor is worth the time and free!
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Dimitre

Liked: Cleanliness, amenities, property conditions & facilities
Great hotel! Art, food and drinks were fantastic
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Shane

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great atmosphere and amenities.
Stayed 1 night in Dec 2025
Verified

8/10 Good

Devon

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Enjoyed our stay to bring in the new year.
Stayed 2 nights in Dec 2025
Verified

10/10 Excellent

Stacy

Liked: Cleanliness, amenities, property conditions & facilities
Staff was great!
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Elizabeth

Liked: Cleanliness, staff & service, amenities
Great staff and very clean room.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Elizabeth

Liked: Cleanliness, amenities, property conditions & facilities
Beautiful space. Clean room. Friendly staff.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Deontae

Liked: Cleanliness, amenities, property conditions & facilities
6 day stay was wonderful
Stayed 6 nights in Dec 2025
Verified

8/10 Good

SHELBY

Staff and amenities were great. Bathroom and Carpet clea miess
Stayed 2 nights in Feb 2026
Verified

6/10 Okay

Aurora

Liked: Cleanliness
Disliked: Staff & service, amenities
The valet was so nice. She was the best empire
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Sarah

Liked: Cleanliness, amenities, property conditions & facilities
Pleasant staff
Stayed 3 nights in Feb 2026
Verified

10/10 Excellent

Diana

Liked: Cleanliness, property conditions & facilities
Room was clean stuff was friendly and everyone was super nice
Stayed 2 nights in Feb 2026
Verified

10/10 Excellent

Juanita

Liked: Cleanliness, amenities, property conditions & facilities
The rooms were nice and clean. Staff was friendly.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

ANDREA Nicole

Liked: Cleanliness, staff & service, amenities
Always a wonderful stay! The staff is top notch and the space is perfect for the imaginative mind! Love love love!
Stayed 2 nights in Oct 2025
Verified

10/10 Excellent

Michelle

Liked: Cleanliness, staff & service, amenities
Everything was perfect!
Stayed 2 nights in Jan 2026