Search Panama City luxury spa hotels

Our top choices for a great stay

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
The price is CA $483 per night from Apr 27 to Apr 28
CA $483
CA $532 total
Apr 27 - Apr 28
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property ...
9.8/10 Exceptional! (630 reviews)
Opens in a new windowSofitel Legend Casco Viejo, Panama City
Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo

4.5 out of 5
The price is CA $468 per night from Apr 27 to Apr 28
CA $468
CA $515 total
Apr 27 - Apr 28
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 5 restaurants. Our guests praise the helpful staff and the property ...
9.8/10 Exceptional! (289 reviews)
Opens in a new windowHotel La Compañía Casco Antiguo
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
The price is CA $375 per night from May 2 to May 3
CA $375
CA $413 total
May 2 - May 3
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (683 reviews)
Opens in a new windowThe Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Hyatt Regency Panama City

Hyatt Regency Panama City

4.5 out of 5
The price is CA $225 per night from Apr 7 to Apr 8
CA $225
CA $247 total
Apr 7 - Apr 8
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Popular attractions Via Espana and Avenida Balboa ...
9.6/10 Exceptional! (241 reviews)
Opens in a new windowHyatt Regency Panama City
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
The price is CA $270 per night from May 1 to May 2
CA $270
CA $297 total
May 1 - May 2
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (1,005 reviews)
Opens in a new windowBristol Panama, a Registry Collection Hotel
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
The price is CA $392 per night from Apr 20 to Apr 21
CA $392
CA $431 total
Apr 20 - Apr 21
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (1,002 reviews)
Opens in a new windowWaldorf Astoria Panama
Hilton Panama

Hilton Panama

5 out of 5
The price is CA $317 per night from May 1 to May 2
CA $317
CA $349 total
May 1 - May 2
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the helpful staff in our ...
8.8/10 Excellent! (1,000 reviews)
Opens in a new windowHilton Panama
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

4.5 out of 5
The price is CA $202 per night from Apr 6 to Apr 7
CA $202
CA $222 total
Apr 6 - Apr 7
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and a casino. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (1,000 reviews)
Opens in a new windowSortis Hotel, Spa & Casino, Autograph Collection by Marriott
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
The price is CA $236 per night from Apr 27 to Apr 28
CA $236
CA $259 total
Apr 27 - Apr 28
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.4/10 Very Good! (1,490 reviews)
Opens in a new windowMegapolis Hotel Panamá
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.