Search Panama City luxury spa hotels
Our top choices for a great stay
Sofitel Legend Casco Viejo, Panama City
The price is CA $532 per night from Jan 13 to Jan 14
CA $532
CA $586 total
Jan 13 - Jan 14, 2026
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property ...
9.8/10 Exceptional! (554 reviews)
Hyatt Regency Panama City
The price is CA $186 per night from Dec 20 to Dec 21
CA $186
CA $204 total
Dec 20 - Dec 21
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Popular attractions Albrook Shopping Mall and Avenida ...
9.8/10 Exceptional! (123 reviews)
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
The price is CA $308 per night from Dec 19 to Dec 20
CA $308
CA $339 total
Dec 19 - Dec 20
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (638 reviews)
Hotel La Compañía Casco Antiguo
The price is CA $443 per night from Dec 23 to Dec 24
CA $443
CA $487 total
Dec 23 - Dec 24
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 5 restaurants. Our guests praise the helpful staff and the property ...
9.6/10 Exceptional! (258 reviews)
Bristol Panama, a Registry Collection Hotel
The price is CA $276 per night from Jan 14 to Jan 15
CA $276
CA $304 total
Jan 14 - Jan 15, 2026
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,005 reviews)
Hilton Panama
The price is CA $289 per night from Jan 2 to Jan 3
CA $289
CA $318 total
Jan 2 - Jan 3, 2026
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the helpful staff in our ...
8.8/10 Excellent! (1,002 reviews)
Waldorf Astoria Panama
The price is CA $303 per night from Jan 3 to Jan 4
CA $303
CA $334 total
Jan 3 - Jan 4, 2026
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (1,001 reviews)
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
The price is CA $219 per night from Jan 6 to Jan 7
CA $219
CA $241 total
Jan 6 - Jan 7, 2026
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and a casino. Our guests praise the helpful staff and the clean rooms in ...
8.6/10 Excellent! (1,003 reviews)
Megapolis Hotel Panamá
The price is CA $191 per night from Dec 19 to Dec 20
CA $191
CA $210 total
Dec 19 - Dec 20
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.4/10 Very Good! (1,272 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
