See all properties

21C Museum Hotel St Louis

4.5 star property
4.5-star luxury hotel near St. Louis Union Station

Choose dates to view prices

Photo gallery for 21C Museum Hotel St Louis

Restaurant
Exterior
Exterior
Bar (on property)
Massages

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, City Museum
    ‪5 min walk‬
  • Place, St. Louis Union Station
    ‪8 min walk‬
  • Place, Enterprise Center
    ‪8 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪19 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 King Bed

9.0 out of 10
Wonderful
(86 reviews)
  • 29 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(27 reviews)
  • 39 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

Room (Bunk Bed)

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • 22 sq m
  • Sleeps 2
  • 1 Twin Bunk Bed

View all photos for Loft, 2 Queen Beds

Loft, 2 Queen Beds

Loft, 2 Queen Beds

8.0 out of 10
Very good
(1 review)
  • 40 sq m
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, Accessible (Accessible)

  • 25 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C)

  • 104 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library)

  • City view
  • 68 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(1 review)
  • 51 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible

  • 36 sq m
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Suite, 1 Double Bed, Accessible

  • 48 sq m
  • Sleeps 2
  • 1 Double Bed

You may also like

Ad
Terrace/patio

Four Seasons Hotel St Louis

Downtown St. Louis
  • Pool
  • Hot tub
  • Spa
  • Pet friendly
4.7 out of 5, Exceptional, 1,000 reviews
The price is CA $568
CA $664 total
includes taxes & fees
Mar 1 - Mar 2
Four Seasons Hotel St Louis

About the area

St. Louis

Heart of St. Louis.Within a 10-minute walk of this Downtown West hotel, you'll find St. Louis Union Station and City Museum. Also, Enterprise Center is within half a mile (1 km) and Busch Stadium is within 2 miles (3 km).

What's nearby

  • Washington Avenue Historic District - 2 min walk - 0.2 km
  • City Museum - 5 min walk - 0.4 km
  • St. Louis Union Station - 8 min walk - 0.7 km
  • Enterprise Center - 8 min walk - 0.7 km
  • St. Louis Aquarium at Union Station - 11 min walk - 1.0 km

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 24 min drive

Restaurants

  • ‪Imo's Pizza Headquarters & Retail Store - ‬7 min walk
  • ‪Budweiser Kiel Club - ‬6 min walk
  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪White Knight Diner - ‬4 min walk
  • ‪Blood & Sand - ‬2 min walk

About this property

21C Museum Hotel St Louis

4.5-star luxury hotel near St. Louis Union Station
21C Museum Hotel St Louis offers its guests an indoor pool, a steam room, and a fitness center. There's a restaurant on site, as well as a coffee shop/cafe. You can enjoy a drink at the bar/lounge. WiFi is free in public spaces.

Business amenities include a business center and meeting rooms. Spa services, a vending machine, and concierge services are also featured at the luxury 21C Museum Hotel St Louis . For a fee, parking is available.

This 4.5-star St. Louis hotel is smoke free.

  • 104 guestrooms or units
  • Meeting rooms
  • Business facilities
  • Breakfast available (surcharge)
  • Dry cleaning
  • Front desk (24 hours)
  • Storage area for luggage
  • Concierge
  • Pool or billiards table
  • ATM
  • Elevator
  • No smoking on site
  • Bar or lounge
  • Coffee shop
  • Dining venue
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and safes. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries, and hair dryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs, and phones. Additionally, rooms include complimentary bottled water and irons/ironing boards. Change of towels and change of bedsheets can be requested. Housekeeping is provided daily.

Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

Similar properties

Property amenity
Drury Plaza Hotel St. Louis at the Arch
  • Pool
  • Hot tub
  • Breakfast included
  • Pet friendly
4.7 out of 5, Exceptional, 3,330 reviews
The price is CA $185
CA $216 total
includes taxes & fees
Mar 4 - Mar 5
Drury Plaza Hotel St. Louis at the Arch

Property amenities

Family friendly

  • Indoor pool
  • Soundproofed rooms

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

Room amenities

Entertainment

  • Flat-screen TV with premium digital channels

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • Pets: USD 100 per accommodation, per stay
  • Only dogs are allowed
  • Service animals are exempt from fees

Children and extra beds

  • Children are welcome.
  • Rollaway/extra beds are not available.
  • Cribs (infant beds) are not available.

Property payment types

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Service fee: USD 5 per accommodation, per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector, and outdoor lighting
Charges for extra guests may apply and vary according to property policy.
A cash deposit, credit card, or debit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. This property accepts Visa, Mastercard, and American Express. Cash is not accepted. For guests' safety, the property includes a fire extinguisher, a smoke detector, and outdoor lighting in each accommodation.

We should mention

  • Reservations are needed for massage services. For reservations, contact the hotel before arrival using the contact information on the booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1160 out of 1625 reviews
Rating 8 - Good. 249 out of 1625 reviews
Rating 6 - Okay. 109 out of 1625 reviews
Rating 4 - Poor. 49 out of 1625 reviews
Rating 2 - Terrible. 58 out of 1625 reviews

9.2/10

Cleanliness

9.0/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

Reviews

4/10 Poor

Katherine

Liked: Amenities
Greeted with an ask for a cc. Told this $230 room hotel that it was my sisters bday and asked if anything could be done. I was told no. It’s not hard to make someone’s day. Esp in the hospitality industry. Not asking for freebies, just asking for a simple gesture to make someone’s stay unforgettable for their birthday. Super disappointed.
Stayed 1 night in Jan 2026

10/10 Excellent

Rufus

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Dec 2025

8/10 Good

Evan

Liked: Cleanliness, staff & service, amenities
Love this hotel and have stayed many times. Original room was not suitable (no iron or coffee machine, which are standard), but front desk quickly gave another room.
Stayed 1 night in Nov 2025

10/10 Excellent

Mark

Travelled with family
Liked: Cleanliness, staff & service, amenities
This place is awesome, it's a destination in itself.
Stayed 1 night in Nov 2025

10/10 Excellent

Margaret

Stayed 1 night in Nov 2025

10/10 Excellent

Lacy S

Stayed 2 nights in Nov 2025

10/10 Excellent

Joan

Stayed 1 night in Nov 2025

10/10 Excellent

garry

Stayed 1 night in Nov 2025

8/10 Good

Richard

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
James who assisted us along the way was very helpful. We did not have breakfast although we did spend some time at the bar and it was very enjoyable. The drinks were special and you could tell that the bartenders knew what they were doing.
Stayed 1 night in Nov 2025

10/10 Excellent

Joseph

Stayed 2 nights in Nov 2025

8/10 Good

mell

Stayed 1 night in Nov 2025

10/10 Excellent

Chris

Liked: Cleanliness, amenities, property conditions & facilities
Great staff and clean room
Stayed 2 nights in Nov 2025

6/10 Okay

Kerrie, Arlington Heights

Travelled with family
Liked: Property conditions & facilities
Disliked: Cleanliness
Very cool vibe from the moment you enter. The gentlemen at valet/door are great even if you choose alternate parking options! Great location to hot spots City Museum, Foundry etc..Restaurant solid and great bar from self proclaimed foodies. Breakfast nice if on the go otherwise I’d venture out. Amenities- pics of a basketball court on site that no longer exists. This was disappointing because my son banked on it and a deciding factor. Bathroom towels are small and need to be replaced. No information in the room on the hotel. Had to click around the website. The place could be cleaner. Dust bunnies and spiders in the hotel room corners, bathroom floor was dirty, toilet paper roll needed to be changed when we checked in. Elevators were dirty with mud and spilled items at night and same in the morning. My glass was sticky/poor wash. For a four star hotel, I’d expect the details to be handled.
Stayed 2 nights in Nov 2025

10/10 Excellent

Robin

Travelled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Everything form the room to the bar to the valet were all amazing.
Stayed 1 night in Nov 2025

10/10 Excellent

Christopher

Liked: Cleanliness, staff & service, amenities
Beautiful venue; comfortable room; clean; good location.
Stayed 2 nights in Nov 2025

10/10 Excellent

Billy

Stayed 1 night in Nov 2025

10/10 Excellent

Jeff

Stayed 2 nights in Nov 2025

10/10 Excellent

Hanna

Liked: Cleanliness, staff & service, amenities
Great vibes
Stayed 1 night in Nov 2025

10/10 Excellent

MONIQUE

Liked: Cleanliness
Stayed 1 night in Nov 2025

10/10 Excellent

Kristin

Travelled with family
Liked: Cleanliness, amenities, property conditions & facilities
Clean rooms, amazing art and unique everything!
Stayed 1 night in Nov 2025

6/10 Okay

Jemel

Liked: Property conditions & facilities
Disliked: Cleanliness, staff & service
Ok
Stayed 2 nights in Nov 2025

10/10 Excellent

Megan

Business traveller
Liked: Cleanliness, property conditions & facilities, room comfort
Incredible lofted ceilings - detailed and thoughtful way to engage with a relaxing and business experience.
Stayed 3 nights in Nov 2025

10/10 Excellent

Mahjabeen

Stayed 1 night in Nov 2025

10/10 Excellent

Theresa

Liked: Cleanliness, staff & service, amenities
Clean, quiet and the staff was great!
Stayed 2 nights in Nov 2025

10/10 Excellent

Hannah

Liked: Staff & service, amenities
Disliked: Cleanliness
Great room, good staff and amenities.
Stayed 1 night in Nov 2025