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21C Museum Hotel St Louis

4.5 star property
4.5-star luxury hotel near Enterprise Center

Choose dates to view prices

Photo gallery for 21C Museum Hotel St Louis

Exterior
Lobby
Indoor pool
Room, 1 King Bed, Corner
1 bedroom, in-room safe, desk, laptop workspace

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Bar

Explore the area

Map
1528 Locust street, St. Louis, MO, 63103
  • St. Louis Union Station
    ‪6 min walk‬
  • Enterprise Center
    ‪6 min walk‬
  • City Museum
    ‪6 min walk‬
  • St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪21 min drive‬

Room options

Loft, 2 Queen Beds

  • Sleeps 4
  • 2 Queen Beds

Luxury Suite, 1 King Bed

  • Sleeps 2
  • 1 King Bed

View all photos for Room (Bunk Bed)

Room (Bunk Bed)

Room (Bunk Bed)

8.0 out of 10
Very good
(5 reviews)
  • Sleeps 2
  • 1 Twin Bunk Bed

Deluxe Room, Accessible (Accessible)

  • Sleeps 2
  • 1 King Bed

Suite, 1 King Bed (Library)

  • Sleeps 2
  • 1 King Bed

Suite, 1 King Bed (21C)

  • Sleeps 2
  • 1 King Bed

Deluxe Room, 1 Double Bed, Accessible

  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(56 reviews)
  • 29 sq m
  • Sleeps 2
  • 1 King Bed

Deluxe Suite, 1 Double Bed, Accessible

  • Sleeps 2
  • 1 Double Bed

View all photos for Deluxe Double Room, 2 Queen Beds

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Double Room, 2 Queen Beds

8.2 out of 10
Very good
(16 reviews)
  • 34 sq m
  • Sleeps 4
  • 2 Queen Beds

Deluxe Room, 1 Double Bed, Accessible

  • Sleeps 4
  • 1 Double Bed

View all photos for Room, 1 King Bed, Corner

Room, 1 King Bed, Corner

Room, 1 King Bed, Corner

8.8 out of 10
Excellent
(19 reviews)
  • 30 sq m
  • City view
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Suite, 1 King Bed

  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Suite, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Suite, 1 King Bed

9.2 out of 10
Wonderful
(5 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

1 bedroom, in-room safe, desk, laptop workspace

Luxury Double Room, 2 Queen Beds

8.8 out of 10
Excellent
(15 reviews)
  • 39 sq m
  • Sleeps 4
  • 2 Queen Beds

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Exterior

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About the area

St. Louis

Heart of St. Louis.Within a 10-minute walk of this Downtown West hotel, you'll find Enterprise Center and City Museum. Also, St. Louis Union Station is within half a mile (1 km) and Busch Stadium is within 2 miles (3 km).

What's nearby

  • St. Louis Union Station - 6 min walk - 0.6 km
  • Enterprise Center - 6 min walk - 0.6 km
  • City Museum - 6 min walk - 0.6 km
  • Busch Stadium - 14 min walk - 1.2 km
  • Gateway Arch - 2 min drive - 1.8 km

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 26 min drive

Restaurants

  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪Grand Hall Lounge Union Station - ‬11 min walk
  • ‪Hair of the Dog - ‬7 min walk
  • ‪Peabody Lounge - ‬6 min walk
  • ‪Medina Mediterranean Grill - ‬5 min walk

About this property

21C Museum Hotel St Louis

4.5-star luxury hotel near Enterprise Center
21C Museum Hotel St Louis offers its guests an indoor pool, a steam room, and a fitness center. There's a restaurant on site, as well as a coffee shop/cafe. You can enjoy a drink at the bar/lounge. WiFi is free in public spaces.

Business amenities include a business center and meeting rooms. Spa services, a vending machine, and concierge services are also featured at the luxury 21C Museum Hotel St Louis . For a fee, parking is available.

This 4.5-star St. Louis hotel is smoke free.

  • 104 guestrooms or units
  • Meeting rooms
  • Business facilities
  • Breakfast available (surcharge)
  • Dry cleaning
  • Front desk (24 hours)
  • Storage area for luggage
  • Concierge
  • Pool or billiards table
  • ATM
  • Elevator
  • No smoking on site
  • Bar or lounge
  • Coffee shop
  • Dining venue
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and safes. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries, and hair dryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs, and phones. Additionally, rooms include complimentary bottled water and irons/ironing boards. Change of towels and change of bedsheets can be requested. Housekeeping is provided daily.

Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

Languages

English

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Property amenities

Family friendly

  • Indoor pool
  • Soundproofed rooms

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

Room amenities

Entertainment

  • Flat-screen TV with premium digital channels

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

  • Pets: USD 100 per accommodation, per stay
  • Only dogs are allowed
  • Service animals are exempt from fees

Children and extra beds

  • Children are welcome.
  • Rollaway/extra beds are not available.
  • Cribs (infant beds) are not available.

Property payment types

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Service fee: USD 5 per accommodation, per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting
Charges for extra guests may apply and vary according to property policy.
A cash deposit, credit card, or debit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. This property accepts Visa, Mastercard, and American Express. Cash is not accepted. For guests' safety, the property includes a smoke detector and outdoor lighting in each accommodation.

We should mention

  • Reservations are needed for massage services. For reservations, contact the hotel before arrival using the contact information on the booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 861 out of 1192 reviews
Rating 8 - Good. 181 out of 1192 reviews
Rating 6 - Okay. 67 out of 1192 reviews
Rating 4 - Poor. 37 out of 1192 reviews
Rating 2 - Terrible. 46 out of 1192 reviews

9.2/10

Cleanliness

9.2/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

9.2/10

Eco-friendliness

Reviews

10/10 Excellent

Claudia

Liked: Cleanliness, staff & service, property conditions & facilities
Great hotel
Stayed 4 nights in Apr 2025

10/10 Excellent

Holly

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Mar 2025

8/10 Good

Nathalie

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Mar 2025

10/10 Excellent

Toni

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Mar 2025

6/10 Okay

Arron

Business traveller
Liked: Staff & service, amenities
Disliked: Cleanliness, property conditions & facilities
I’ve been visiting St. Louis for over 12 years and used to try different hotels — until I stayed at 21c. Since that first visit, I haven’t stayed anywhere else. It had a fresh energy, a unique atmosphere, and the kind of people that made it feel exciting. The real standout has always been the staff, especially the bar and restaurant team — people like Carson, Cam, and JoJo. Their effort, warmth, and attention to detail make every stay feel like more than just a hotel visit. Over time, they’ve become familiar faces and genuine friends. But on my most recent stay, I was let down — not by them, but by housekeeping and management. My room simply wasn’t clean: mould in the shower, someone else’s hair, stains left untouched, and amenities not replaced. Once you see it, you start noticing more — and unfortunately, I did. I raised it with the team (not even their job to fix) and they went out of their way to make things right — offering a credit and even leaving a bottle of their own gin in my room. Lovely gestures, truly appreciated — but the mould was still there the next day. The issue wasn’t fixed. For a short stay, I’d still recommend it. But for anything longer, if you value cleanliness and comfort, I’d think twice. The team out front are brilliant — but they’re being let down by what’s happening behind the scenes.
Stayed 9 nights in Mar 2025

10/10 Excellent

Steve

Stayed 1 night in Mar 2025

8/10 Good

JANA

Travelled with group
Liked: Staff & service, amenities, property conditions & facilities
The property is very special, with a historic and totally renovated pool and spa, and a large art exhibit. The bar and lobby are loaded with art and beautifully designed surroundings. Only one of three elevators were working this week, so a lot of waiting and frankly feeling unsafe. The breakfast restaurant is good. There is no lunch option and the front desk has zero intel regarding outside options. The dinner menu is ridiculously expensive and not very enticing. Drinks are crazy expensive ($14 for 3 oz of sav blanc) The valet is $45/night in kind of a rundown, crummy neighborhood.
Stayed 2 nights in Mar 2025

10/10 Excellent

Veronica

Liked: Cleanliness, staff & service, property conditions & facilities
Beautiful hotel. Amazing indoor pool. My kids Loved the bunk beds.
Stayed 2 nights in Mar 2025

10/10 Excellent

Rebecca

Travelled with partner
Liked: Amenities
We stayed here for a night while we were in town to watch the Blues. It's close enough to walk to the stadium or take a quick uber. It was close to union station too. Wonderful hotel! We will be back.
Stayed 1 night in Mar 2025

10/10 Excellent

Jocelynne

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 2 nights in Mar 2025

10/10 Excellent

Verified traveller

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great
Stayed 1 night in Feb 2025

10/10 Excellent

Christopher

Travelled with group
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 4 nights in Mar 2025

10/10 Excellent

Ashley

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Mar 2025

10/10 Excellent

Tracey

Travelled with family, Business traveller
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We had a couple of hurdles when we arrived and the staff was so kind and went out of their way to make it right. I would recommend this place to anyone and will definitely stay here again. Kind people make everything else seem so minor. I appreciate everyone I have come in contact with during this stay!
Stayed 1 night in Mar 2025

2/10 Terrible

Deborah

Liked: Cleanliness, property conditions & facilities
Stayed 1 night in Mar 2025

10/10 Excellent

Alexus

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Mar 2025

8/10 Good

Ju Hui

Stayed 2 nights in Mar 2025

10/10 Excellent

Bryan

Travelled with partner
Liked: Cleanliness, staff & service, property conditions & facilities
Great boutique hotel in downtown St. Louis, the hotel was busy when we checked in and the front desk staff was a bit harried, but they gave us the essential information we needed. The art gallery on the second floor was a great addition to our stay, as was the on sight restaurant, The Idol Wolf, amazing food, and service. The hotel itself has a very cool, and eclectic vibe, but is beginning to look a little “run down”. But overall a good experience, we will definitely stay here again if we are ever in the area.
Stayed 1 night in Mar 2025

10/10 Excellent

Lisa

Travelled with group
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Mar 2025

10/10 Excellent

chastity

Travelled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Really clean and updated. The museum on the 2nd floor was nice to browse. Valet guys were funny and friendly. The gal at check in was not as friendly. Would stay here again for convenience to concerts, sporting events, etc.
Stayed 1 night in Mar 2025

10/10 Excellent

Joseph

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

March 21c couples stay

The hotel, bar, restaurants and art were amazing. Would definitely stay here again. Some improvements; need a hair dryer in room without asking, need hooks in bathroom and need higher quality toilet paper.
Stayed 2 nights in Mar 2025

10/10 Excellent

Brandi

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 3 nights in Mar 2025

10/10 Excellent

Latisha

Business traveller
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very nice and comfortable hotel.
Stayed 2 nights in Jan 2025

10/10 Excellent

Amy

Stayed 4 nights in Feb 2025

10/10 Excellent

Jonathan

Stayed 5 nights in Feb 2025