Find and compare 5 Star hotels in Syros

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Featured Syros 5 Star hotels

Palladium Hotel

Palladium Hotel

5 out of 5
Plati Yialos Mykonos Mykonos Island
Fully refundableReserve now, pay when you stay
The price is CA $210 per night from May 6 to May 7
CA $210
CA $264 total
May 6 - May 7
includes taxes & fees
Book a stay at this luxury hotel in Mykonos. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the helpful staff in ...
9.8/10 Exceptional! (807 reviews)
Excellent hotel with great staff!

Reviewed on Oct 23, 2025

Opens in a new windowPalladium Hotel
Myconian Ambassador Hotel Relais & Chateaux

Myconian Ambassador Hotel Relais & Chateaux

5 out of 5
Platis Gialos Mykonos Mykonos Island
The price is CA $204 per night from May 8 to May 9
CA $204
CA $256 total
May 8 - May 9
includes taxes & fees
Book a stay at this luxury hotel in Mykonos. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
Opens in a new windowMyconian Ambassador Hotel Relais & Chateaux
Semeli Hotel

Semeli Hotel

5 out of 5
Mykonos Town Mykonos Mykonos Island
The price is CA $293 per night from Apr 14 to Apr 15
CA $293
CA $358 total
Apr 14 - Apr 15
includes taxes & fees
Book a stay at this luxury hotel in Mykonos. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.4/10 Exceptional! (569 reviews)
The staff is amazing, I love how welcoming they make you feel, very attentive, friendly, respectful. Perfectly located near everything.

Reviewed on Mar 25, 2026

Opens in a new windowSemeli Hotel
Nissaki Boutique Hotel

Nissaki Boutique Hotel

5 out of 5
Platis Gialos Beach Mykonos Mykonos Island
Fully refundableReserve now, pay when you stay
The price is CA $207 per night from Apr 13 to Apr 14
CA $207
CA $260 total
Apr 13 - Apr 14
includes taxes & fees
Book a stay at this luxury hotel in Mykonos. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the property condition ...
9.8/10 Exceptional! (829 reviews)
.

Reviewed on Apr 8, 2026

Opens in a new windowNissaki Boutique Hotel
Tropicana Hotel , Suites & Villas Mykonos

Tropicana Hotel , Suites & Villas Mykonos

5 out of 5
Paradise Beach Mykonos
Book a stay at this luxury hotel in Mykonos. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the pool and the helpful staff in our reviews. ...
9.8/10 Exceptional! (672 reviews)
Absolutely amazing❤️

Reviewed on Jan 31, 2026

Opens in a new windowTropicana Hotel , Suites & Villas Mykonos
CAVO TAGOO MYKONOS

CAVO TAGOO MYKONOS

5 out of 5
TAGOO MYKONOS Mykonos
Book a stay at this luxury hotel in Mykonos. Enjoy free breakfast, free WiFi, and free valet parking. Popular attractions Mykonos Old Port and Mykonos New Port ...
Opens in a new windowCAVO TAGOO MYKONOS
Myconian Korali

Myconian Korali

5 out of 5
Main Street, Mykonos Town Mykonos
The price is CA $310 per night from May 1 to May 2
CA $310
CA $377 total
May 1 - May 2
includes taxes & fees
Book a stay at this luxury hotel in Mykonos. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our ...
9.4/10 Exceptional! (545 reviews)
Excellent views and the rooms were spacious.

Reviewed on Dec 29, 2025

Opens in a new windowMyconian Korali
Mykonos Blu, A Grecotel Resort to Live

Mykonos Blu, A Grecotel Resort to Live

5 out of 5
Psarou Mykonos Mykonos Island
The price is CA $433 per night from May 8 to May 9
CA $433
CA $517 total
May 8 - May 9
includes taxes & fees
Book a stay at this luxury hotel in Mykonos. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (301 reviews)
We had the room with jacuzzi outside and it was really nice! Food was good for breakfast, many choices but not to many. The lounge areas was nice and relaxing. The private beach area was very convenient!

Reviewed on Oct 27, 2025

Opens in a new windowMykonos Blu, A Grecotel Resort to Live
Bill&Coo Mykonos

Bill&Coo Mykonos

5 out of 5
Megali Ammos Mykonos Mykonos Island
Fully refundableReserve now, pay when you stay
The price is CA $527 per night from Apr 15 to Apr 16
CA $527
CA $624 total
Apr 15 - Apr 16
includes taxes & fees
Book a stay at this luxury hotel in Mykonos. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Mykonos Old Port and Mykonos New Port are ...
9.6/10 Exceptional! (185 reviews)
Terrible service they look and smile but don’t ask if you’d like coffee at breakfast or Dinks at the pool they give you a link when you ask for reservations. The gym is awful one working treadmill one not so take a number and wait in line There’s no hot tub on the premises except for in the spa we ...

Reviewed on Aug 10, 2025

Opens in a new windowBill&Coo Mykonos
Deos Mykonos - A Myconian Collection Hotel

Deos Mykonos - A Myconian Collection Hotel

5 out of 5
Agios Vasilios, Chora Mykonou Mykonos Mykonos Island
The price is CA $608 per night from May 1 to May 2
CA $608
CA $717 total
May 1 - May 2
includes taxes & fees
Book a stay at this luxury hotel in Mykonos. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Mykonos Old Port and Mykonos New Port are ...
10/10 Exceptional! (32 reviews)
Breakfast & Hotel was exceptional. Highly recommend!

Reviewed on Dec 3, 2025

Opens in a new windowDeos Mykonos - A Myconian Collection Hotel
Don't see what you're looking for?
See all available properties in Syros
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Five Star Hotels in Syros

Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Syros to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Syros 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Syros before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Syros hotel reviews by fellow wanderers