Eastern Panama Vacations 2026 from CA $1,778

Eastern Panama flight + hotel packages

Price found within the past 48 hours. Click for updated prices.

Megapolis Hotel Panamá

San Francisco

CA $1,778

per person

May 1 - May 8

found 15 hours ago

Roundtrip non-stop flight included

Edmonton (YEG) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Avenida Balboa and Via Espana are located nearby.

Central Hotel Panama Casco Viejo

Casco Viejo

CA $2,643

per person

Apr 12 - Apr 19

found 1 day ago

Roundtrip flight included

Edmonton (YEG) to Panama City (PTY)

Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Cinta Costera and Amador Causeway are located nearby.

Hotel Riu Plaza Panama

Bella Vista

CA $1,792

per person

Apr 12 - Apr 19

found 1 day ago

Roundtrip flight included

Edmonton (YEG) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Via Espana and Avenida Balboa are located nearby.

Casa Mallet by Wynwood House

Casco Viejo

CA $2,174

per person

Apr 12 - Apr 19

found 1 day ago

Roundtrip flight included

Edmonton (YEG) to Panama City (PTY)

Stay at this apartment in Panama City. Enjoy free WiFi, parking (surcharge), and premium bedding. Popular attractions Cinta Costera and Amador Causeway are located nearby.

Dreams Playa Bonita Panama - All Inclusive

CA $2,938

per person

Apr 23 - Apr 30

found 1 day ago

Roundtrip flight included

Edmonton (YEG) to Panama City (PTY)

Book a stay at this beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Amador Causeway and Albrook Shopping Mall are located nearby.

Top Eastern Panama hotels deals

Hotel Cocotal

La Guaira Isla Grande Provincia de Colón

Free cancellation

Reserve now, pay when you stay

CA $85

CA $154 total

Apr 6 - Apr 7

includes taxes & fees

Stay at this hotel in Isla Grande. Enjoy free breakfast, free WiFi, and 20 restaurants. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

Breakfast included

Pet-friendly

Ordovician Beach Resort

Isla Grande Isla Grande Colon

CA $590

CA $658 total

Apr 1 - Apr 2

includes taxes & fees

Book a stay at this luxury resort in Isla Grande. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

On private beach

Pool

HOTEL ISLA GRANDE

Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province

Get rates

Book a stay at this beach hotel in Isla Grande. Enjoy free breakfast, a beach locale, and onsite spa services. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

Breakfast included

Spa

Konsenda San Blas

Llano Cartí Km 11 El Llano Panamá Province

Free cancellation

Reserve now, pay when you stay

Get rates

Stay at this hotel in El Llano. Enjoy free breakfast, free parking, and a garden.

Breakfast included

Parking included

San Blas Paradise Private Cabins on Shipwreck Island - meals included

Perro Island Ailigandi Guna Yala

Get rates

Book a stay at this beach hotel in Ailigandí. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge).

Breakfast included

Cocoloco - Catamaran Lagoon 52F SAN BLAS

El Porvenir Narganá Guna Yala

Free cancellation

Reserve now, pay when you stay

CA $2,411

CA $2,656 total

Apr 6 - Apr 7

includes taxes & fees

Book a stay at this beach property in San Blas Islands. Enjoy free breakfast, free WiFi, and a beach locale. Popular attractions Porvenir Museum and Isla Chichime are located nearby.

Breakfast included

Free WiFi

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Secluded island in the Guna Yala region of Panama

Isla Diablo

Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area.

Isla Chichime

Commune with nature and explore the great outdoors at Isla Chichime during your travels in San Blas Islands. Take in the festivals while you're in the area.

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Narganá. Stroll along the seaside or experience the area's festivals.

Frequently asked questions

How much are vacation packages to Eastern Panama?

Exciting adventures await in Eastern Panama, with Travelocity vacation packages starting from as low as CA $1,778. Including flights and hotels, these awesome deals make it a breeze to see more of our beautiful planet.

Where can I get the best vacation package deals for Eastern Panama?

You can snap up amazing Eastern Panama package deals with Travelocity. Mix and match from 400 air carriers and 1,000,000 worldwide properties and turn those travel dreams into a reality.

Why should I purchase my Eastern Panama vacation package with Travelocity?

We offer 24/7 support, top-quality service and a Price Match Guarantee. Life's a great big journey — and we have alluring destinations for you to journey to all across the world. Wander with us and your wallet will thank you for it.

Can I save money on my Eastern Panama car rental if I bundle it with my hotel or flight?

Certainly. And our Eastern Panama vacation packages are the perfect way to do it. In just a few clicks you can save cash as well as time by bundling your bookings. Pick up the keys to your rental car and feel the freedom of the open road. Searching for things to do? Add some tours or experiences to your package and make savings on those too.

What is there to do in Eastern Panama?

You'll be happy to know Eastern Panama is brimming with incredible things to see and do, however Isla Mamey and Cayos Holandeses are right up there with the very best.