Book Exclusive Eastern Panama Vacation Packages

Choose one or more items to build your trip:

Eastern Panama flight + hotel packages

Price found within the past 48 hours. Click for updated prices.
Mahogany Suites
Central Hotel Panama Casco Viejo
Villa Marina Lodge & Condos
Hotel Riu Plaza Panama
Villa Botero By Casa Mojito B&B

Top Eastern Panama hotels deals

Don't see what you're looking for?
See all available properties in Eastern Panama
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Frequently asked questions

How much are vacation packages to Eastern Panama?
Exciting adventures await in Eastern Panama, with Travelocity vacation packages starting from as low as CA $927. Including flights and hotels, these awesome deals make it a breeze to see more of our beautiful planet.
Where can I get the best vacation package deals for Eastern Panama?
You can snap up amazing Eastern Panama package deals with Travelocity. Mix and match from 400 air carriers and 1,000,000 worldwide properties and turn those travel dreams into a reality.
Why should I purchase my Eastern Panama vacation package with Travelocity?
We offer 24/7 support, top-quality service and a Price Match Guarantee. Life's a great big journey — and we have alluring destinations for you to journey to all across the world. Wander with us and your wallet will thank you for it.
Can I save money on my Eastern Panama car rental if I bundle it with my hotel or flight?
Certainly. And our Eastern Panama vacation packages are the perfect way to do it. In just a few clicks you can save cash as well as time by bundling your bookings. Pick up the keys to your rental car and feel the freedom of the open road. Searching for things to do? Add some tours or experiences to your package and make savings on those too.
What is there to do in Eastern Panama?
You'll be happy to know Eastern Panama is brimming with incredible things to see and do, however Isla Mamey and Cayos Holandeses are right up there with the very best.

Photos of local treasures

Browse Eastern Panama vacation photos for more inspiration

50 Shades of blue. Sailing through the San Blas Islands in Panama lets you experience  a pure paradise and crystal clear water. You can buy fresh fish and other seefood drirectly from local fishermen. If you want you can also play Robinson Crusoe on islands with literally only one palm tree. 
#BVSBlue
50 Shades of blue. Sailing through the San Blas Islands in Panama lets you experience  a pure paradise and crystal clear water. You can buy fresh fish and other seefood drirectly from local fishermen. If you want you can also play Robinson Crusoe on islands with literally only one palm tree. 
#BVSBlue
A Kuna Yala man  headed out to fish. If you have ever dreamed of spending a night or two on a small, private island, check out Kuna Yala. If you don't like roughing it a little bit, this might not be for you. There are cabins with flushing toilets but no electricity and the shower water is rather cool. Great place to get away from crowds and unplug though.

#islands #peaceful
#Adventure
#water
#ocean
#boat
#trovember
A definite bucketlist place to visit if ever in #Panama. #SanBlas
Secluded island in the Guna Yala region of Panama