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21C Museum Hotel St Louis

4.5 star property
4.5-star luxury hotel near St. Louis Union Station

Choose dates to view prices

Photo gallery for 21C Museum Hotel St Louis

Restaurant
Exterior
Bar (on property)
Massages
Exterior

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, City Museum
    ‪5 min walk‬
  • Place, St. Louis Union Station
    ‪8 min walk‬
  • Place, Enterprise Center
    ‪8 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪20 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(104 reviews)
  • 29 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(33 reviews)
  • 39 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

Room (Bunk Bed)

Room (Bunk Bed)

8.4 out of 10
Very good
(7 reviews)
  • 22 sq m
  • Sleeps 2
  • 1 Twin Bunk Bed

View all photos for Loft, 2 Queen Beds

Loft, 2 Queen Beds

Loft, 2 Queen Beds

8.0 out of 10
Very good
(1 review)
  • 40 sq m
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Room, Accessible (Accessible)

10.0 out of 10
Exceptional
(1 review)
  • 25 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C)

  • 104 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library)

  • City view
  • 68 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(2 reviews)
  • 51 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible

  • 36 sq m
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout drapes

Deluxe Suite, 1 Double Bed, Accessible

  • 48 sq m
  • Sleeps 2
  • 1 Double Bed

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About the area

St. Louis

Heart of St. Louis.Within a 10-minute walk of this Downtown West hotel, you'll find St. Louis Union Station and City Museum. Also, Enterprise Center is within half a mile (1 km) and Busch Stadium is within 2 miles (3 km).

What's nearby

  • Washington Avenue Historic District - 2 min walk - 0.2 km
  • City Museum - 5 min walk - 0.4 km
  • St. Louis Union Station - 8 min walk - 0.7 km
  • Enterprise Center - 8 min walk - 0.7 km
  • St. Louis Aquarium at Union Station - 11 min walk - 1.0 km

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 24 min drive

Restaurants

  • ‪Imo's Pizza Headquarters & Retail Store - ‬7 min walk
  • ‪Budweiser Kiel Club - ‬6 min walk
  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪City Museum Rooftop Cafe - ‬5 min walk
  • ‪Blood & Sand - ‬2 min walk

About this property

21C Museum Hotel St Louis

4.5-star luxury hotel near St. Louis Union Station
21C Museum Hotel St Louis offers its guests an indoor pool, a steam room, and a fitness center. There's a restaurant on site, as well as a coffee shop/cafe. You can enjoy a drink at the bar/lounge. WiFi is free in public spaces.

Business amenities include a business center and meeting rooms. Spa services, a vending machine, and concierge services are also featured at the luxury 21C Museum Hotel St Louis . For a fee, parking is available.

This 4.5-star St. Louis hotel is smoke free.

  • 104 guestrooms or units
  • Meeting rooms
  • Business facilities
  • Breakfast available (surcharge)
  • Dry cleaning
  • Front desk (24 hours)
  • Storage area for luggage
  • Concierge
  • Pool or billiards table
  • ATM
  • Elevator
  • No smoking on site
  • Bar or lounge
  • Coffee shop
  • Dining venue
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and safes. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries, and hair dryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs, and phones. Additionally, rooms include complimentary bottled water and irons/ironing boards. Change of towels and change of bedsheets can be requested. Housekeeping is provided daily.

Guests can pamper themselves by indulging in the onsite spa services. Services include massages.

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Property amenities

Family friendly

  • Indoor pool
  • Soundproofed rooms

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

Room amenities

Entertainment

  • Flat-screen TV with premium digital channels

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • Pets: USD 100 per accommodation, per stay
  • Only dogs are allowed
  • Service animals are exempt from fees

Children and extra beds

  • Children are welcome.
  • Rollaway/extra beds are not available.
  • Cribs (infant beds) are not available.

Property payment types

Important information

Fees

Guests will be asked to pay the following charges at the property:

  • Service fee: USD 5 per accommodation, per stay

We've listed all charges provided to us by the property.

Optional extras

The fees and deposits listed below will be charged at the time of service, check-in, or check-out.

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

This may not be a comprehensive list. Fees and deposits are subject to change and might not include tax.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector, and outdoor lighting
Charges for extra guests may apply and vary according to property policy.
A cash deposit, credit card, or debit card for incidental charges and government-issued photo identification may be required upon check-in.
Special requests are subject to availability at the time of check-in. Special requests can't be guaranteed and may incur additional charges.
    This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession. This property accepts Visa, Mastercard, and American Express. Cash is not accepted. For guests' safety, the property includes a fire extinguisher, a smoke detector, and outdoor lighting in each accommodation.

We should mention

  • Reservations are needed for massage services. For reservations, contact the hotel before arrival using the contact information on the booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1250 out of 1768 reviews
Rating 8 - Good. 275 out of 1768 reviews
Rating 6 - Okay. 121 out of 1768 reviews
Rating 4 - Poor. 56 out of 1768 reviews
Rating 2 - Terrible. 66 out of 1768 reviews

9.2/10

Cleanliness

9.0/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

Reviews

10/10 Excellent

Austin

Stayed 4 nights in Feb 2026

10/10 Excellent

Dimitre

Travelled with group
Liked: Cleanliness, amenities, property conditions & facilities
Great hotel! Art, food and drinks were fantastic
Stayed 1 night in Jan 2026

6/10 Okay

Jolee

Travelled with group
Will not be staying here again. Room was below expectations for the price and not very clean. Restaurant and room service never answered the phone. Valet service was very kind and timely, gym and sauna were dirty, we stayed two nights and had to go to the lobby to get more toilet paper and clean towels after the calling the front desk for them they told us they didn’t have time.
Stayed 2 nights in Jan 2026

10/10 Excellent

Lawren

Stayed 1 night in Jan 2026

10/10 Excellent

Juanita

Travelled with partner
Liked: Cleanliness, amenities, property conditions & facilities
The rooms were nice and clean. Staff was friendly.
Stayed 1 night in Jan 2026

10/10 Excellent

Lauren

Travelled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Jan 2026

8/10 Good

Mikel

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great Location, great atmosphere. Drinks and food on the floor level, beautiful artwork is on display.
Stayed 1 night in Jan 2026

10/10 Excellent

Jennifer

Travelled with partner, Travelled with group
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Cool hotel to stay at near enterprise center. Had fun with the penguins and liked the activities in the hotel (museum, pool table, shuffleboard)
Stayed 1 night in Jan 2026

8/10 Good

Sheryl

Travelled with group
Liked: Cleanliness, property conditions & facilities
Front desk staff were abrupt, there was nothing around the hotel
Stayed 8 nights in Jan 2026

10/10 Excellent

Ricky

Liked: Cleanliness, staff & service, amenities
Front desk, SUPER nice man, very informative. Room- spotless, and COMFY bed! Love staying here! Such a unique place to stay! We love it!
Stayed 1 night in Jan 2026

8/10 Good

Melisa

The staff was really kind
Stayed 2 nights in Jan 2026

10/10 Excellent

Emily

Stayed 1 night in Jan 2026

8/10 Good

Julie

Liked: Cleanliness, amenities, property conditions & facilities
This hotel is so unique and everyone was so nice! Loved my room (Room 709) however on 2 dates (January 6 and 10), my room was not serviced at all. My towels were still in a pile on the floor when I came back at night. I still had extras so it was okay, but just surprised me. I loved all of the amenities and the bed was very comfortable. Idol Wolf was incredible! Food was so delicious!! Loved going to Good Press in the morning too! The Black Walnut Latte was so good!
Stayed 7 nights in Jan 2026

10/10 Excellent

David

Stayed 7 nights in Jan 2026

8/10 Good

Charlotte

Quirky and boho chic accommodate
Stayed 4 nights in Jan 2026

10/10 Excellent

Elisabeth J

Stayed 4 nights in Jan 2026

8/10 Good

wayne

Stayed 6 nights in Jan 2026

10/10 Excellent

Logan

Liked: Cleanliness, staff & service, amenities
The hotel is beautiful! And most importantly, the bed was very comfortable. It has a fridge in the room, which most boutique hotels lack, so that was convenient. I would stay here again.
Stayed 6 nights in Jan 2026

8/10 Good

David

Stayed 1 night in Jan 2026

10/10 Excellent

Isaiah

Stayed 2 nights in Jan 2026

10/10 Excellent

Brianna

Stayed 1 night in Jan 2026

10/10 Excellent

Corbin

Good vibe
Stayed 1 night in Dec 2025

6/10 Okay

Keisha

Travelled with family
Liked: Amenities
The check- in process was not a pleasant one, bathroom floors were not clean, robes provided in the bathroom were unclean, and the food was overpriced for the quality.
Stayed 2 nights in Dec 2025

10/10 Excellent

Elizabeth

Liked: Cleanliness, staff & service, amenities
Great staff and very clean room.
Stayed 1 night in Jan 2026

6/10 Okay

Gregg

Travelled with partner
Disliked: Property conditions & facilities
Our room wasn’t ready at 5pm, could not check in for about 1.5 hrs. Luckily they have a fantastic bar. Room was small but well appointed. The doors to some cabinets would not shut. The shower door would not shut. We did not have enough shampoo conditioner or body wash. The museum was nice. The restaurant is great. Probably wouldn’t stay again but would definitely eat at the restaurant or have drinks at the bar.
Stayed 2 nights in Jan 2026