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Featured Santa Cruz 4 Star hotels

TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz

4 out of 5
Av. San Martin, Calle 9 Este Santa Cruz
The price is CA $136 per night from May 23 to May 24
CA $136
CA $136 total
May 23 - May 24
Stay at this hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.2/10 Wonderful! (161 reviews)
"My go too hotel whenever I'm in town!"

Reviewed on Mar 23, 2026

Opens in a new windowTRYP by Wyndham Santa Cruz
Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo Santa Cruz
The price is CA $185 per night from May 30 to May 31
CA $185
CA $185 total
May 30 - May 31
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Centro Cultural ...
9/10 Wonderful! (426 reviews)
"Excellent hotel, very clean, cozy, spotless and very stilish"

Reviewed on Apr 19, 2026

Opens in a new windowCamino Real Hotel
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 out of 5
San Martin Avenue Esq Street E - E Santa Cruz
The price is CA $128 per night from May 26 to May 27
CA $128
CA $128 total
May 26 - May 27
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Ventura Mall and Patio Design LifeStyle ...
9.2/10 Wonderful! (272 reviews)
"It's good place, with good surroundings."

Reviewed on Apr 29, 2026

Opens in a new windowHampton by Hilton Santa Cruz/Equipetrol, Bolivia
Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra

4.5 out of 5
5to anillo Avenida La Salle # 4500 Santa Cruz
The price is CA $173 per night from Jun 3 to Jun 4
CA $173
CA $173 total
Jun 3 - Jun 4
Book a stay at this luxury hotel in Santa Cruz. Enjoy free WiFi, a full-service spa, and 2 bars/lounges. Popular attractions Centro Cultural Oriental and Ventura ...
9.2/10 Wonderful! (87 reviews)
"Great room, spacious, quiet and the shower was great"

Reviewed on Mar 2, 2026

Opens in a new windowSwissôtel Santa Cruz De La Sierra
Hotel Maywa

Hotel Maywa

4 out of 5
2do anillo av.santacruz #1007 Santa Cruz Santa Cruz Department
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and a rooftop terrace. Popular attractions Blacutt Square and Santa ...
9.2/10 Wonderful! (10 reviews)
"The structure and service was fantastic"

Reviewed on Sep 17, 2025

Opens in a new windowHotel Maywa
Buganvillas Hotel Suites & Spa

Buganvillas Hotel Suites & Spa

4 out of 5
Av. Roca y Coronado No. 901 Santa Cruz
Book a stay at this family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...
Opens in a new windowBuganvillas Hotel Suites & Spa
Royal Lodge Hotel

Royal Lodge Hotel

4.5 out of 5
Avenida San Martin 200 Santa Cruz
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Ventura Mall and Patio Design LifeStyle ...
Opens in a new windowRoyal Lodge Hotel
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4 Star Hotels Santa Cruz

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Santa Cruz 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Santa Cruz will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Santa Cruz, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Santa Cruz hotel reviews by fellow wanderers

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