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Featured Santa Cruz 4 Star hotels

Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo, Equipetrol Norte, Santa Cruz
The price is CA $216 per night from Dec 1 to Dec 2
CA $216
CA $216 total
Dec 1 - Dec 2
Stay at this 4.5-star luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Santa Cruz ...
8.8/10 Excellent! (404 reviews)
The parrots. Unique

Reviewed on Oct 25, 2025

Opens in a new windowCamino Real Hotel
TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz

4 out of 5
Av. San Martin, Calle 9 Este, no. 4, Equipetrol., Santa Cruz
The price is CA $97 per night from Dec 7 to Dec 8
CA $97
CA $97 total
Dec 7 - Dec 8
Stay at this 4-star hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.2/10 Wonderful! (141 reviews)
I suggest more fruits for breakfast , very limited options , king staff

Reviewed on Aug 2, 2025

Opens in a new windowTRYP by Wyndham Santa Cruz
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 out of 5
San Martin Avenue Esq Street E - E, Santa Cruz
The price is CA $90 per night from Dec 13 to Dec 14
CA $90
CA $90 total
Dec 13 - Dec 14
Stay at this 4.5-star luxury hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Ventura Mall and Patio Design LifeStyle ...
9.2/10 Wonderful! (253 reviews)
Our room was clean and comfortable. The staff were friendly and very helpful!

Reviewed on Oct 25, 2025

Opens in a new windowHampton by Hilton Santa Cruz/Equipetrol, Bolivia
Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra

4.5 out of 5
5to anillo Avenida La Salle # 4500, Santa Cruz
The price is CA $208 per night from Nov 29 to Nov 30
CA $208
CA $208 total
Nov 29 - Nov 30
Stay at this 4.5-star luxury hotel in Santa Cruz. Enjoy free WiFi, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Santa Cruz Zoo ...
9.2/10 Wonderful! (79 reviews)
Great night at the Swissotel
It was a great one-night stay at the Santa Cruz Swissôtel. The hotel was impecable, service excellent, and the staff very friendly and professional. We shall return to this hotel in the future.

Reviewed on Jul 14, 2025

Opens in a new windowSwissôtel Santa Cruz De La Sierra
Hotel Maywa

Hotel Maywa

4 out of 5
2do anillo av.santacruz #1007, Santa Cruz, Santa Cruz Department
Stay at this 4-star business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and a rooftop terrace. Popular attractions Blacutt Square and Santa ...
9.2/10 Wonderful! (11 reviews)
The structure and service was fantastic

Reviewed on Sep 17, 2025

Opens in a new windowHotel Maywa
Buganvillas Hotel Suites & Spa

Buganvillas Hotel Suites & Spa

4 out of 5
Av. Roca y Coronado No. 901, Santa Cruz
Stay at this 4-star family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...
7.4/10 Good! (93 reviews)
Extremely satisfy with the service that this resort provided to us. Definitely will return back. Follow me on YouTube #TeamWithERVING

Reviewed on Aug 14, 2021

Opens in a new windowBuganvillas Hotel Suites & Spa
Royal Lodge Hotel

Royal Lodge Hotel

4.5 out of 5
Avenida San Martin 200, Equipetrol Norte, Santa Cruz
Stay at this 4.5-star luxury hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Ventura Mall and Patio Design LifeStyle ...
Disappointing stay
I was really looking forward to a bit of luxury after travelling for 6 weeks. Unfortunately I was greeted with judgment for having a backpack and then found that the facilities in my room were shocking. There wasn't even any hot water.

Reviewed on Aug 11, 2018

Opens in a new windowRoyal Lodge Hotel
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4 Star Hotels Santa Cruz

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Santa Cruz 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Santa Cruz will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Santa Cruz, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Santa Cruz hotel reviews by fellow wanderers