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Featured Syracuse 4 Star hotels

Mercure Siracusa Prometeo

Mercure Siracusa Prometeo

4 out of 5
Viale Teracati 20, Syracuse, SR
Fully refundableReserve now, pay when you stay
The price is CA $128 per night from Dec 2 to Dec 3
CA $128
CA $163 total
Dec 2 - Dec 3
includes taxes & fees
Stay at this 4-star spa hotel in Syracuse. Enjoy free WiFi, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (472 reviews)
Great staff. Good location

Reviewed on Oct 14, 2025

Opens in a new windowMercure Siracusa Prometeo
Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

4 out of 5
Via Vittorio Veneto 93, Syracuse, SR
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in Syracuse. Enjoy free breakfast, free WiFi, and 2 bars/lounges. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (887 reviews)
Can't say enough great things about Algila! The staff was so helpful & accommodating, awesome location, nice rooms and large common areas to gather aft

Reviewed on Nov 7, 2025

Opens in a new windowAlgila' Ortigia Charme Hotel
UNA HOTELS One Siracusa

UNA HOTELS One Siracusa

4 out of 5
Via Diodoro Siculo 4, Syracuse, SR
Fully refundableReserve now, pay when you stay
The price is CA $202 per night from Dec 4 to Dec 5
CA $202
CA $230 total
Dec 4 - Dec 5
includes taxes & fees
Stay at this 4-star spa hotel in Syracuse. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.6/10 Excellent! (519 reviews)
Large room and balcony, staff on welcome desk friendly and helpful. Well equipped room facilities. Great idea of honesty bar and Lola the robot was quirky. Room top garden beautiful. It was disappointing that some furniture was broken or ripped. The spa was 40 euros each to use which we were not ...

Reviewed on Oct 24, 2025

Opens in a new windowUNA HOTELS One Siracusa
Grande Albergo Alfeo

Grande Albergo Alfeo

4 out of 5
Via Nino Bixio 5, Syracuse, SR
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Syracuse. Enjoy free breakfast, free WiFi, and room service. Popular attractions Lungomare di Ortigia and Syracuse ...
8.6/10 Excellent! (637 reviews)
The bathroom shower leaked all over the floor so we put a towel on the floor. The toilet push button was very finicky The rooms were dated The breakfast was very good Excellent location The staff were very helpful

Reviewed on Oct 1, 2025

Opens in a new windowGrande Albergo Alfeo
Hotel Parco delle Fontane

Hotel Parco delle Fontane

4 out of 5
Viale Scala Greca, 325, Syracuse, SR
Fully refundableReserve now, pay when you stay
The price is CA $132 per night from Nov 21 to Nov 22
CA $132
CA $151 total
Nov 21 - Nov 22
includes taxes & fees
Stay at this 4-star property in Syracuse. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Lungomare di Ortigia and Rope-makers' Cave are ...
9/10 Wonderful! (271 reviews)
Wonderful oasis in a busy section of town. Superb breakfast. Room was clean and comfortable, although room equipment could use some attention.

Reviewed on Oct 20, 2025

Opens in a new windowHotel Parco delle Fontane
Grand Hotel Villa Politi

Grand Hotel Villa Politi

4 out of 5
Via Maria Politi Laudien 2, Syracuse, SR
Fully refundableReserve now, pay when you stay
The price is CA $137 per night from Nov 23 to Nov 24
CA $137
CA $156 total
Nov 23 - Nov 24
includes taxes & fees
Stay at this 4-star beach hotel in Syracuse. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the comfy rooms in our ...
8.6/10 Excellent! (915 reviews)
Staff were good Breakfast a bit disappointing

Reviewed on Nov 9, 2025

Opens in a new windowGrand Hotel Villa Politi
Eureka Palace Hotel Spa Resort

Eureka Palace Hotel Spa Resort

4 out of 5
Strada Spinagallo 50, Syracuse, SR
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in Syracuse. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8/10 Very Good! (314 reviews)
OK

Reviewed on Oct 20, 2025

Opens in a new windowEureka Palace Hotel Spa Resort
Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri

4 out of 5
42 Via Malta, Syracuse, SR
Fully refundableReserve now, pay when you stay
The price is CA $195 per night from Nov 20 to Nov 21
CA $195
CA $222 total
Nov 20 - Nov 21
includes taxes & fees
Stay at this 4-star hotel in Syracuse. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Popular attractions Lungomare di Ortigia and Santa Lucia ...
8.8/10 Excellent! (36 reviews)
Excelente ubicación!!!

Reviewed on Oct 10, 2025

Opens in a new windowHotel Palazzo Cavalieri
Albatros Hotel

Albatros Hotel

4 out of 5
Via Elorina 168, Syracuse, SR
Stay at this 4-star business-friendly hotel in Syracuse. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. ...
8.6/10 Excellent! (99 reviews)
Staff very kind. One of the travelers uses a wheelchair, the hotel was perfect for his condition. Breakfast excellent! Great location if you have transportation

Reviewed on Apr 27, 2025

Opens in a new windowAlbatros Hotel
Charme Hotel Henry's House

Charme Hotel Henry's House

4 out of 5
Via del Castello Maniace n. 68, Syracuse, SR
Stay at this 4-star boutique hotel in Syracuse. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (318 reviews)
I loved this hotel. The staff was great and very helpful. The location was perfect for shopping and dining, people watching and sightseeing. The hotel is very charming with an eclectic array of art everywhere. The hotel has a sweet outdoor patio with real grapes/grapevines growing above it and it ...

Reviewed on Oct 24, 2025

Opens in a new windowCharme Hotel Henry's House
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4 Star Hotels Syracuse

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Syracuse 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Syracuse will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Syracuse, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Syracuse hotel reviews by fellow wanderers