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Featured Syracuse 4 Star hotels

Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

4 out of 5
Via Vittorio Veneto 93 Syracuse SR
Book a stay at this family-friendly hotel in Syracuse. Enjoy free breakfast, free WiFi, and 24-hour room service. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (906 reviews)
Friendly staff. Beautiful property. Clean room but the sea view wasn’t directly from the room; you had to go up several stairs to a terrace, From the terrace the view was great but we were there in the winter so it was chilly.

Reviewed on Dec 24, 2025

Opens in a new windowAlgila' Ortigia Charme Hotel
Mercure Siracusa Prometeo

Mercure Siracusa Prometeo

4 out of 5
Viale Teracati 20 Syracuse SR
Book a stay at this spa hotel in Syracuse. Enjoy free WiFi, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (477 reviews)
Wry welcoming place to stay

Reviewed on Dec 15, 2025

Opens in a new windowMercure Siracusa Prometeo
Grand Hotel Villa Politi

Grand Hotel Villa Politi

4 out of 5
Via Maria Politi Laudien 2 Syracuse SR
Fully refundableReserve now, pay when you stay
The price is CA $159 per night from Jan 5 to Jan 6
CA $159
CA $182 total
Jan 5 - Jan 6, 2026
includes taxes & fees
Book a stay at this beach hotel in Syracuse. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the property condition ...
8.6/10 Excellent! (920 reviews)
Staff were good Breakfast a bit disappointing

Reviewed on Nov 9, 2025

Opens in a new windowGrand Hotel Villa Politi
Eureka Palace Hotel Spa Resort

Eureka Palace Hotel Spa Resort

4 out of 5
Strada Spinagallo 50 Syracuse SR
Fully refundableReserve now, pay when you stay
Book a stay at this spa hotel in Syracuse. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8/10 Very Good! (316 reviews)
OK

Reviewed on Oct 20, 2025

Opens in a new windowEureka Palace Hotel Spa Resort
Hotel Parco delle Fontane

Hotel Parco delle Fontane

4 out of 5
Viale Scala Greca, 325 Syracuse SR
Fully refundableReserve now, pay when you stay
The price is CA $104 per night from Jan 12 to Jan 13
CA $104
CA $119 total
Jan 12 - Jan 13, 2026
includes taxes & fees
Stay at this property in Syracuse. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Rope-makers' Cave and Latomia del Paradiso are located ...
9/10 Wonderful! (272 reviews)
Wonderful oasis in a busy section of town. Superb breakfast. Room was clean and comfortable, although room equipment could use some attention.

Reviewed on Oct 20, 2025

Opens in a new windowHotel Parco delle Fontane
UNA HOTELS One Siracusa

UNA HOTELS One Siracusa

4 out of 5
Via Diodoro Siculo 4 Syracuse SR
Fully refundableReserve now, pay when you stay
The price is CA $189 per night from Jan 6 to Jan 7
CA $189
CA $215 total
Jan 6 - Jan 7, 2026
includes taxes & fees
Book a stay at this spa hotel in Syracuse. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.6/10 Excellent! (520 reviews)
Large room and balcony, staff on welcome desk friendly and helpful. Well equipped room facilities. Great idea of honesty bar and Lola the robot was quirky. Room top garden beautiful. It was disappointing that some furniture was broken or ripped. The spa was 40 euros each to use which we were not ...

Reviewed on Oct 24, 2025

Opens in a new windowUNA HOTELS One Siracusa
Palazzo Artemide - VRetreats

Palazzo Artemide - VRetreats

4 out of 5
Via Roma 66 Syracuse SR
Stay at this hotel in Syracuse. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.4/10 Exceptional! (653 reviews)
The room was always clean and bed sheets changed regularly. The staff very helpful and accommodating. We haven’t tried breakfast.

Reviewed on Dec 29, 2025

Opens in a new windowPalazzo Artemide - VRetreats
Grande Albergo Alfeo

Grande Albergo Alfeo

4 out of 5
Via Nino Bixio 5 Syracuse SR
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Syracuse. Enjoy free breakfast, free WiFi, and room service. Popular attractions Syracuse Forum Ruins and Santa ...
8.6/10 Excellent! (641 reviews)
Good front desk staff, welcoming breakfast staff, clean room and good area for walking to attractions.

Reviewed on Dec 2, 2025

Opens in a new windowGrande Albergo Alfeo
Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri

4 out of 5
42 Via Malta Syracuse SR
Fully refundableReserve now, pay when you stay
The price is CA $281 per night from Dec 30 to Dec 31
CA $281
CA $321 total
Dec 30 - Dec 31
includes taxes & fees
Stay at this hotel in Syracuse. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Popular attractions Santa Lucia Bridge and Syracuse Forum Ruins ...
8.8/10 Excellent! (39 reviews)
Excelente ubicación!!!

Reviewed on Oct 10, 2025

Opens in a new windowHotel Palazzo Cavalieri
Charme Hotel Henry's House

Charme Hotel Henry's House

4 out of 5
Via del Castello Maniace n. 68 Syracuse SR
The price is CA $309 per night from Jan 6 to Jan 7
CA $309
CA $357 total
Jan 6 - Jan 7, 2026
includes taxes & fees
Book a stay at this boutique hotel in Syracuse. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (320 reviews)
Great location. Very friendly and helpful staff. Nice breakfast.

Reviewed on Nov 14, 2025

Opens in a new windowCharme Hotel Henry's House
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4 Star Hotels Syracuse

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Syracuse 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Syracuse will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Syracuse, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Syracuse hotel reviews by fellow wanderers