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Featured Brookline 5 Star hotels

Omni Boston Hotel at the Seaport

Omni Boston Hotel at the Seaport

5 out of 5
450 Summer Street Boston MA
Fully refundableReserve now, pay when you stay
The price is CA $215 per night from Apr 5 to Apr 6
CA $215
CA $307 total
Apr 5 - Apr 6
includes taxes & fees
Book a stay at this luxury hotel in Boston. Enjoy free WiFi, a full-service spa, and 4 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
9.2/10 Wonderful! (4,549 reviews)
This hotel is clean, the staff are friendly - just a great experience every time I stay here.

Reviewed on Apr 2, 2026

Opens in a new windowOmni Boston Hotel at the Seaport
Encore Boston Harbor

Encore Boston Harbor

5 out of 5
1 Broadway Everett MA
Fully refundableReserve now, pay when you stay
The price is CA $280 per night from Apr 5 to Apr 6
CA $280
CA $313 total
Apr 5 - Apr 6
includes taxes & fees
Book a stay at this luxury hotel in Everett. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the clean rooms in ...
9.6/10 Exceptional! (3,629 reviews)
Perfect hotel

Reviewed on Apr 3, 2026

Opens in a new windowEncore Boston Harbor
The Langham, Boston

The Langham, Boston

5 out of 5
250 Franklin St Boston MA
Fully refundableReserve now, pay when you stay
The price is CA $607 per night from Apr 10 to Apr 11
CA $607
CA $706 total
Apr 10 - Apr 11
includes taxes & fees
Book a stay at this luxury hotel in Boston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean rooms ...
9.6/10 Exceptional! (1,000 reviews)
Very nice hotel

Reviewed on Mar 30, 2026

Opens in a new windowThe Langham, Boston
InterContinental Boston by IHG

InterContinental Boston by IHG

5 out of 5
510 Atlantic Ave Boston MA
The price is CA $312 per night from Apr 12 to Apr 13
CA $312
CA $426 total
Apr 12 - Apr 13
includes taxes & fees
Book a stay at this luxury hotel in Boston. Enjoy a full-service spa, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (1,102 reviews)
Everything was perfect couldn’t have asked for a better room or service.

Reviewed on Apr 3, 2026

Opens in a new windowInterContinental Boston by IHG
The Newbury Boston

The Newbury Boston

5 out of 5
15 Arlington St Boston MA
Fully refundableReserve now, pay when you stay
The price is CA $675 per night from Apr 11 to Apr 12
CA $675
CA $859 total
Apr 11 - Apr 12
includes taxes & fees
Book a stay at this luxury hotel in Boston. Enjoy breakfast (surcharge), 24-hour room service, and a 24-hour fitness center. Our guests praise the helpful staff ...
9.2/10 Wonderful! (607 reviews)
Lovely lovely staff and accommodation.

Reviewed on Mar 31, 2026

Opens in a new windowThe Newbury Boston
Boston Harbor Hotel

Boston Harbor Hotel

5 out of 5
70 Rowes Wharf Boston MA
The price is CA $771 per night from Apr 10 to Apr 11
CA $771
CA $899 total
Apr 10 - Apr 11
includes taxes & fees
Book a stay at this luxury hotel in Boston. Enjoy free WiFi, a marina, and breakfast (surcharge). Our guests praise the helpful staff and the room service in ...
9.8/10 Exceptional! (1,001 reviews)
Clean room, friendly staff, great amenities

Reviewed on Apr 3, 2026

Opens in a new windowBoston Harbor Hotel
The Liberty, a Marriott Luxury Collection Hotel, Boston

The Liberty, a Marriott Luxury Collection Hotel, Boston

5 out of 5
215 Charles St Boston MA
Fully refundableReserve now, pay when you stay
The price is CA $341 per night from Apr 5 to Apr 6
CA $341
CA $438 total
Apr 5 - Apr 6
includes taxes & fees
Book a stay at this luxury hotel in Boston. Enjoy free WiFi, 2 restaurants, and 4 bars/lounges. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (1,003 reviews)
Great places, one of the front desk people are not friendly. Need new staff

Reviewed on Apr 3, 2026

Opens in a new windowThe Liberty, a Marriott Luxury Collection Hotel, Boston
Four Seasons Hotel One Dalton Street, Boston

Four Seasons Hotel One Dalton Street, Boston

5 out of 5
One Dalton Street Boston MA
Fully refundableReserve now, pay when you stay
The price is CA $738 per night from Apr 12 to Apr 13
CA $738
CA $859 total
Apr 12 - Apr 13
includes taxes & fees
Book a stay at this luxury hotel in Boston. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (400 reviews)
wonderful stay

Reviewed on Mar 16, 2026

Opens in a new windowFour Seasons Hotel One Dalton Street, Boston
Mandarin Oriental, Boston

Mandarin Oriental, Boston

5 out of 5
776 Boylston St Boston MA
Fully refundableReserve now, pay when you stay
The price is CA $973 per night from Apr 10 to Apr 11
CA $973
CA $1,133 total
Apr 10 - Apr 11
includes taxes & fees
Book a stay at this luxury hotel in Boston. Enjoy a full-service spa, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff and ...
9.4/10 Exceptional! (409 reviews)
Beautiful hotel. From the moment you are greeted by the valet, bell hop, front reception you are treated like royalty. 5 stars all around!

Reviewed on Mar 16, 2026

Opens in a new windowMandarin Oriental, Boston
Four Seasons Hotel Boston

Four Seasons Hotel Boston

5 out of 5
200 Boylston St Boston MA
The price is CA $1,109 per night from Apr 5 to Apr 6
CA $1,109
CA $1,291 total
Apr 5 - Apr 6
includes taxes & fees
Book a stay at this luxury hotel in Boston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the room service ...
9.4/10 Exceptional! (467 reviews)
Perfect in every way

Reviewed on Apr 2, 2026

Opens in a new windowFour Seasons Hotel Boston
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Five Star Hotels in Brookline

Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Brookline to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Brookline 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Brookline before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

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