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Featured Syracuse 5 Star hotels

Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

5 out of 5
Viale Mazzini, 12 Syracuse SR
Fully refundableReserve now, pay when you stay
The price is CA $493 per night from Jul 23 to Jul 24
CA $493
CA $558 total
Jul 23 - Jul 24
includes taxes & fees
Book a stay at this luxury hotel in Syracuse. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (602 reviews)
"one of the best hotels we have stayed at in recent memory. the room was comfortable and clean, the breakfasts were amazing, and the staff were so friendly and beyond helpful! highly recommend!"

Reviewed on Jul 2, 2026

Opens in a new windowGrand Hotel Ortigia Siracusa
Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection

5 out of 5
Via Riva Nazario Sauro Syracuse SR
Fully refundableReserve now, pay when you stay
The price is CA $564 per night from Aug 1 to Aug 2
CA $564
CA $636 total
Aug 1 - Aug 2
includes taxes & fees
Book a stay at this luxury hotel in Syracuse. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property condition ...
9.4/10 Exceptional! (268 reviews)
"Clean, good service, nice location"

Reviewed on Jun 23, 2026

Opens in a new windowOrtea Palace Hotel, Sicily, Autograph Collection
Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World

5 out of 5
Passeggio Adorno 10/12 Syracuse SR
Fully refundableReserve now, pay when you stay
The price is CA $728 per night from Aug 1 to Aug 2
CA $728
CA $817 total
Aug 1 - Aug 2
includes taxes & fees
Book a stay at this luxury hotel in Syracuse. Enjoy free breakfast, free WiFi, and an outdoor pool. Popular attractions Lungomare di Ortigia and Tropical Aquarium ...
9.4/10 Exceptional! (87 reviews)
"We stayed here for a few days whilst we were getting married nearby. The staff couldn’t have been more attentive from the minute we arrived with recommendations and helping arrange logistics. Fabio at the pool deck was fantastic and made us feel so looked after. Cannot rate highly enough. Stunning ..."

Reviewed on Jun 30, 2026

Opens in a new windowGrand Hotel Des Ètrangers - The Leading Hotels of the World
Minareto

Minareto

5 out of 5
Via del Faro Massolivieri 26 Syracuse SR
The price is CA $689 per night from Jul 24 to Jul 25
CA $689
CA $774 total
Jul 24 - Jul 25
includes taxes & fees
Book a stay at this luxury hotel in Syracuse. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Lungomare di Ortigia and Spiaggia del Minareto ...
8.8/10 Excellent! (272 reviews)
"Fantastic place to stay. Very beautiful resort on a cliff top with both a sandy and rocky beach both with crystal clear water. Only thing I would recommend is that you hire a car as it's a drive to go anywhere else unless you get a water taxi to Ortigia (50Euros for 2 each way). Very helpful staff ..."

Reviewed on Jul 3, 2026

Opens in a new windowMinareto
Caportigia Boutique Hotel

Caportigia Boutique Hotel

5 out of 5
Viale Montedoro 76 Syracuse SR
Fully refundableReserve now, pay when you stay
The price is CA $216 per night from Jul 10 to Jul 11
CA $216
CA $254 total
Jul 10 - Jul 11
includes taxes & fees
Book a stay at this luxury hotel in Syracuse. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (283 reviews)
"Valentina was so very lovely and helpful. She was very informative as well. The property is very beautiful and a great location. My only criticism is the sound the doors make when you unlock the room door. It’s a very load electronic buzzing sound. Late at night you can hear other people coming in ..."

Reviewed on Jun 18, 2026

Opens in a new windowCaportigia Boutique Hotel
Dimora Caiammari Luxury Hotel & Spa

Dimora Caiammari Luxury Hotel & Spa

5 out of 5
Via Daniele Impellizzeri Syracuse SR
The price is CA $466 per night from Jul 10 to Jul 11
CA $466
CA $529 total
Jul 10 - Jul 11
includes taxes & fees
Book a stay at this luxury hotel in Syracuse. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the helpful staff in our reviews. Popular ...
Opens in a new windowDimora Caiammari Luxury Hotel & Spa
Wellness & Spa Hotel Principe di Fitalia

Wellness & Spa Hotel Principe di Fitalia

5 out of 5
Traversa Tonnara di Terrauzza 51 Syracuse SR
Fully refundableReserve now, pay when you stay
The price is CA $574 per night from Jul 17 to Jul 18
CA $574
CA $648 total
Jul 17 - Jul 18
includes taxes & fees
Book a stay at this luxury hotel in Syracuse. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
Opens in a new windowWellness & Spa Hotel Principe di Fitalia
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Five Star Hotels in Syracuse

Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Syracuse to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Syracuse 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Syracuse before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Syracuse hotel reviews by fellow wanderers