Find and compare 5 Star hotels in Syracuse
Wander Wisely with exceptional service, 24/7 support
Save an extra 10% or more on select hotels with Member Discounts
Access exclusive hotel deals, only with the Travelocity app
Check prices for these dates
Featured Syracuse 5 Star hotels
Grand Hotel Ortigia Siracusa
"one of the best hotels we have stayed at in recent memory. the room was comfortable and clean, the breakfasts were amazing, and the staff were so friendly and beyond helpful! highly recommend!"
Reviewed on Jul 2, 2026
Ortea Palace Hotel, Sicily, Autograph Collection
"Clean, good service, nice location"
Reviewed on Jun 23, 2026
Grand Hotel Des Ètrangers - The Leading Hotels of the World
"We stayed here for a few days whilst we were getting married nearby. The staff couldn’t have been more attentive from the minute we arrived with recommendations and helping arrange logistics. Fabio at the pool deck was fantastic and made us feel so looked after. Cannot rate highly enough. Stunning ..."
Reviewed on Jun 30, 2026
Minareto
"Fantastic place to stay. Very beautiful resort on a cliff top with both a sandy and rocky beach both with crystal clear water. Only thing I would recommend is that you hire a car as it's a drive to go anywhere else unless you get a water taxi to Ortigia (50Euros for 2 each way). Very helpful staff ..."
Reviewed on Jul 3, 2026
Caportigia Boutique Hotel
"Valentina was so very lovely and helpful. She was very informative as well. The property is very beautiful and a great location. My only criticism is the sound the doors make when you unlock the room door. It’s a very load electronic buzzing sound. Late at night you can hear other people coming in ..."
Reviewed on Jun 18, 2026
Dimora Caiammari Luxury Hotel & Spa
Wellness & Spa Hotel Principe di Fitalia
Five Star Hotels in Syracuse
Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Syracuse to make sure your trip is as extravagantly comfortable as you expect.
Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!
Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.
For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Syracuse 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.
Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Syracuse before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.
Recent Syracuse hotel reviews by fellow wanderers
Algila' Ortigia Charme Hotel
"Excellent, charming hotel. Lovely staff and beautiful rooms. We loved it."
Explore More Ways to Travel with Travelocity
- Arenella Hotels
- Brucoli Hotels
- Carrozziere Hotels
- All Inclusive Resorts & in Province of Syracuse
- Hotels near Lido Cala Zaffiro
- Melilli Hotels
- Priolo Gargallo Hotels
- Townhomes in Priolo Gargallo
- Punta Milocca Hotels
- Hotels with Hot Tubs in Solarino
- Solarino Hotels
- Sortino Hotels
- Chalets in Syracuse
- Condos in Syracuse
- All Inclusive Resorts & in Syracuse
- Beach Resorts & in Syracuse
- Casino Resorts & in Syracuse
- Hotels with Waterslides in Syracuse
- Waterpark Hotels and Resorts in Syracuse
- Syracuse Hotels
- Residences in Syracuse
- Villas in Syracuse