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Featured Syracuse 5 Star hotels
Ortea Palace Hotel, Sicily, Autograph Collection
"Cold breakfast food. Bad smell in lobby. Cold in lobby. Kitchen staff disorganized. Tiny shower. Terrible soap dispenser. Overall very mediocre and not inexpensive"
Reviewed on Oct 1, 2026
Grand Hotel Ortigia Siracusa
Grand Hotel Des Ètrangers - The Leading Hotels of the World
Caportigia Boutique Hotel
"Overall the hotel was very nice and in perfect location. We would definitely stay again. Some items they could improve. The reading lights above bed did not work and there was no other source of light except the huge lights for the entire room. The shower floor was super super super slippery. Both ..."
Reviewed on Sep 28, 2026
Dimora Caiammari Luxury Hotel & Spa
Minareto
"One of the most beautiful and luxurious hotels I have ever visited—excellent and spotless. The views were picture-perfect, and the cleanliness and scents were wonderful. The amenities were top-notch, comprehensive, and high-quality, and the hotel facilities were excellent. Highly recommended."
Reviewed on Oct 8, 2026
Wellness & Spa Hotel Principe di Fitalia
Five Star Hotels in Syracuse
Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Syracuse to make sure your trip is as extravagantly comfortable as you expect.
Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!
Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.
For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Syracuse 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.
Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Syracuse before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.
Recent Syracuse hotel reviews by fellow wanderers
Grand Hotel Villa Politi
"Large older hotel, built in 1862 but renovated. Quiet. Situated in an historic park. Many bus tours stay here. Rooms are clean, fairly large and adequately equipped. Bed needs to be upgraded, mattress is hard and uncomfortable. Shower is in the bathtub, you need to step over the bathtub to access. Limited views from rooms. Convenient city bus stop not far from the main gate to access downtown and Ortigia. Free parking for those with rental cars. Breakfast is okay, typical large group buffet-style with chaotic frenzy to grab fresh items in limited quantities. Restaurant for dinner is okay but overpriced. Much better dining options in town."
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