Cheap Flight Deals to Sikeston MO from CA $314

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How to find cheap flights to Sikeston?

The cheapest prices found with in the last 7 days for return flights were CA $374 and CA $314 for one-way flights to Sikeston for the period specified. Prices and availability are subject to change. Additional terms apply

OriginDestinationTravel datesFlights from*
LGASt. LouisJuly 2 to July 6CA $431
LGASt. LouisJuly 2 to July 6CA $431
SEASt. LouisMay 30 to June 6CA $432
LAXSt. LouisMay 27 to June 2CA $575
DENSt. LouisJune 3 to June 6CA $715
PHLSt. LouisJune 2 to June 7CA $20,123
*Prices include taxes and fees
OriginDestinationTravel datesFlights from*
LAXSt. LouisMay 15 to May 18CA $869
TPASt. LouisMay 16 to May 17CA $1,017
DENSt. LouisMay 15 to May 17CA $1,817
*Prices include taxes and fees

Your guide to flights to Sikeston, MO

Delta, American Airlines fly to Sikeston, so use Travelocity to search, find, and compare some truly tempting deals from the 4 airlines—that way you can be sure you’ve found the best deal for you. A flight to Sikeston MO currently costs between CA $374 and CA $20,123. Prices vary, but for the best fares, travel in September when prices are at their lowest.  

Top tips for finding cheap flights to Sikeston  

The cheapest flight for a round trip to Sikeston is currently CA $374. When you search for flights to Sikeston, enter your preferred travel dates then click on ‘flexible dates’ to compare cheap flight tickets to Sikeston for nearby days.  The cheapest month to travel to Sikeston is June from our list of deals available.  

But if you’re flexible about when you travel, you can find great deals on flights across the year. If you’re planning a vacation, you can save more on Travelocity when you bundle flights with car rental and hotel bookings, too. Many airlines currently offer flexible booking options, so look for flights offering no change fees.   

How to cancel flights to Sikeston 

We know plans change, that’s why at Travelocity, we make it as easy as possible for you to cancel or amend your plane tickets. Go to My Trips, enter your itinerary number, then follow the instructions. Many airlines let you cancel flights online free of charge if you booked it in the last 24 hours. Visit Customer Service for more advice.  

Why you should book your flight to Sikeston with Travelocity 

We have top deals on plane tickets even for last minute flights to Sikeston, so you can simply type in your travel dates and compare our best prices. Booking with Travelocity means you get flexible cancellation options, 24/7 support, and, thanks to our Price Match Promise, if the airfare drops after you book, you can get a refund! Whether you’re planning a business trip, weekend getaway, or a family vacation—let Travelocity get you to Sikeston for less. 

Find The Perfect Hotel For After Your Flight

Amazing Place to Stay After Flight to Sikeston

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
The price is CA $99 per night from May 17 to May 18
CA $99
CA $111 total
May 17 - May 18
includes taxes & fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,000 reviews)
Excellent layover stay

Reviewed on May 12, 2026

Opens in a new windowPear Tree Inn Cape Girardeau West
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
The price is CA $87 per night from May 17 to May 18
CA $87
CA $100 total
May 17 - May 18
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,000 reviews)
The room was disgusting. Had dirty sheets on the bed there were visible stains. Bathroom was not clean at all as even agreed with the hotel staff that asked did we want to move rooms, but by then we was already unpacked my family went and got cleaning supplies and had to clean the bathroom and floors ...

Reviewed on May 11, 2026

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 out of 5
3253 William Street Cape Girardeau MO
The price is CA $144 per night from May 17 to May 18
CA $144
CA $162 total
May 17 - May 18
includes taxes & fees
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,001 reviews)
Room was very clean. Breakfast was good with several options. Would recommend staying here.

Reviewed on May 6, 2026

Opens in a new windowHoliday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Save an average of 15% on thousands of hotels when you're signed in
Eagle Inn Charleston

Eagle Inn Charleston

2 out of 5
2811 East Marshall Street Charleston MO
The price is CA $95 per night from May 15 to May 16
CA $95
CA $105 total
May 15 - May 16
includes taxes & fees
Stay at this motel in Charleston. Enjoy free WiFi, free parking, and a health club.
6.6/10 (106 reviews)
Great

Reviewed on Apr 14, 2026

Opens in a new windowEagle Inn Charleston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Sikeston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
The price is CA $87 per night from May 17 to May 18
CA $87
CA $100 total
May 17 - May 18
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,000 reviews)
The room was disgusting. Had dirty sheets on the bed there were visible stains. Bathroom was not clean at all as even agreed with the hotel staff that asked did we want to move rooms, but by then we was already unpacked my family went and got cleaning supplies and had to clean the bathroom and floors ...

Reviewed on May 11, 2026

Opens in a new windowDays Inn and Suites by Wyndham Sikeston
Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau MO
Stay at this apartment in Cape Girardeau. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Riverfront Park and eDen Spa & Salon are located ...
10/10 Exceptional! (225 reviews)
Amazing place to stay at the Cape!

Reviewed on Apr 12, 2026

Opens in a new windowHistorical 'Kage House' Short Term Rental located in "Old Town Cape"
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

2.5 out of 5
2011 North Kingshighway Cape Girardeau MO
The price is CA $91 per night from May 19 to May 20
CA $91
CA $103 total
May 19 - May 20
includes taxes & fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
7.2/10 Good! (740 reviews)
The place was not good at all. If it wasn't for it being so late at night when we arrived, I would have left and demanded a refund. Room was as if someone before me had just left 5 minutes prior to me going in. Not clean at all!!

Reviewed on May 6, 2026

Opens in a new windowQuality Inn Cape Girardeau North
Save an average of 15% on thousands of hotels when you're signed in
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
The price is CA $152 per night from May 18 to May 19
CA $152
CA $175 total
May 18 - May 19
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,000 reviews)
Very nice and clean place with courteous staff.

Reviewed on May 13, 2026

Opens in a new windowDrury Inn & Suites Sikeston, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Sikeston

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
The price is CA $152 per night from May 18 to May 19
CA $152
CA $175 total
May 18 - May 19
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,000 reviews)
Very nice and clean place with courteous staff.

Reviewed on May 13, 2026

Opens in a new windowDrury Inn & Suites Sikeston, MO
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
The price is CA $117 per night from May 17 to May 18
CA $117
CA $134 total
May 17 - May 18
includes taxes & fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,008 reviews)
Room was dirty, there was hair on the wall in the shower, the shower tub was disgusting, the floor was dirty. Breakfast was average nothing great

Reviewed on May 11, 2026

Opens in a new windowBest Western Plus Sikeston I-55
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
The price is CA $123 per night from May 17 to May 18
CA $123
CA $139 total
May 17 - May 18
includes taxes & fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,012 reviews)
Excellent hotel! We enjoy the perks of an evening meal and a good breakfast. Rooms are well maintained and clean.

Reviewed on May 12, 2026

Opens in a new windowDrury Inn & Suites Cape Girardeau
Save an average of 15% on thousands of hotels when you're signed in
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 out of 5
2904 Old Orchard Rd Jackson MO
The price is CA $126 per night from May 19 to May 20
CA $126
CA $137 total
May 19 - May 20
includes taxes & fees
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
8.2/10 Very Good! (766 reviews)
Air Conditioning was noisy, the bathroom door did not close. The linens were dingy. The furniture was subpar, lots of damage on them scratches and dings. The carpet was stained and dirty, the bathroom had water damage around the tub and there were cracks in the ceiling drywall.

Reviewed on Apr 27, 2026

Opens in a new windowComfort Suites Jackson-Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a car after flight to Sikeston?

Frequently asked questions

Which airlines fly to Sikeston?
You won't find many airlines that service Sikeston. So, if you're planning to embark on your long-anticipated adventure from here, book a seat with Cape Air as soon as you can.
Where to stay in Sikeston
Lock in your Sikeston accommodations through Travelocity and then turn your attention to what really matters — creating remarkable travel memories. Pick from 12 lodgings from which you can explore this enticing destination.If you're on the hunt for the top accommodation options in Sikeston, we suggest the Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel and the Hampton Inn Sikeston. Reserve a room and then start booking all your exciting getaway activities.
Places to visit in Sikeston
0 Like some more ideas? 0 But there's more. 0
How to get through airport security fast when traveling to Sikeston
Your adventure to Sikeston starts as soon as you've finished all the security checks. Here are some tips and pointers to help you get through quickly:

  • Security personnel will ask to see your travel ID and boarding pass as part of their checks. Tuck them away in a convenient place, so they're all ready for inspection.
  • Remove your shoes and belt before arriving at the airport security checkpoint. Items like these are not permitted to pass through the body scanner.
  • Make sure your phone, laptop and other electronic devices are easily accessible. These items need to be sent through the X-ray machine separately.
  • When you approach the security checkpoint, you'll be asked to place all creams, gels and liquids in a separate tray for scanning. Make sure they're all packed in containers smaller than 3.4 ounces (100 milliliters) and sealed in a clear zip-lock bag.
  • Security personnel will likely tell you to take off your shoes for the body scanner. Choose a pair that you can slip off easily. There's nothing more irritating than having to do your laces up over and over again.
  • Pocketknives and corkscrews are not permitted on board the aircraft. Tuck them away in your checked luggage to avoid them being confiscated at the airport security checkpoint.

Plane Tickets To Sikeston

Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Sikeston. Browse through our inventory to explore a wide range of cheap flights to Sikeston to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Sikeston as you anxiously await to exit the plane and explore what Sikeston has to offer. Considering all the amazing local food and culture in Sikeston, we won't hold this against you.

When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Sikeston to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Sikeston without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Sikeston with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Sikeston today!

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.