Stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions San Ysidro Border Crossing and U.S. Consulate General Tijuana are located nearby. Discover genuine guest reviews for Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel, in Otay Mesa neighborhood, along with the latest prices and availability – book now.