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Top Mississippi County hotels deals

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2 out of 5
310 S Story St Charleston MO
Free cancellation
Reserve now, pay when you stay
The price is CA $85 per night
CA $85
CA $94 total
Nov 1 - Nov 2
includes taxes & fees
Stay at this motel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews.
Breakfast included
Pet-friendly
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

2.5 out of 5
102 Drake St Charleston MO
Free cancellation
The price is CA $95 per night
CA $95
CA $105 total
Nov 1 - Nov 2
includes taxes & fees
Book a stay at this business-friendly hotel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our reviews.
Pool
Breakfast included
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Free cancellation
Reserve now, pay when you stay
The price is CA $134 per night
CA $134
CA $154 total
Oct 11 - Oct 12
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Central Park and Sikeston Depot Museum are located nearby.
Pool
Breakfast included
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Free cancellation
Reserve now, pay when you stay
The price is CA $94 per night
CA $94
CA $107 total
Nov 1 - Nov 2
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Central Park and Sikeston Depot Museum are located nearby.
Breakfast included
Pet-friendly
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Free cancellation
Reserve now, pay when you stay
The price is CA $121 per night
CA $121
CA $137 total
Nov 1 - Nov 2
includes taxes & fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Central Park and Sikeston Depot Museum are located nearby.
Pool
Breakfast included
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
Free cancellation
Reserve now, pay when you stay
The price is CA $81 per night
CA $81
CA $93 total
Oct 22 - Oct 23
includes taxes & fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot Museum are located nearby.
Breakfast included
Pet-friendly
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Mississippi County attractions

Big Oak Tree State Park

8.0/10 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
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Photos of local treasures

Browse Mississippi County vacation photos for more inspiration

A bridge over a muddy river with green trees and hills in the background.

Frequently asked questions

How much are vacation packages to Mississippi County?
With vacation packages on offer for only , it's not necessary to drain your bank balance for your trip to Mississippi County. Travelocity is here to help. Bundle up experiences, hotels and flights into a package and receive some excellent discounts. The more you book, the more you save.
Where can I get the best vacation package deals for Mississippi County?
No matter what you enjoy doing, Travelocity can help you get your hands on the best Mississippi County package deal. The only thing you have to do is select a combination from our 400 airlines and 1,000,000 properties around the world.
Why should I book my Mississippi County vacation bundle with Travelocity?
By booking your hotel, flights, activities and car rental all in one place, you'll save time and money. We have a dedicated team of experts available 24/7, and you'll know that you'll always score the lowest price possible with our Price Match Guarantee. So, what are you waiting for? Book your dream getaway today and get packing!
Can I save money on my Mississippi County car rental if I bundle it with my hotel or flight?
You certainly can with our Mississippi County vacation packages. With one of these, there are plenty of ways to stretch your travel budget further. Bundle any two or more car, hotel, flight and tour bookings and watch your savings pile up. With your own ride, all the main sights around Mississippi County are within your reach.
Which airport is best for Mississippi County?
If you're going to fly into Mississippi County, it's likely you'll be touching down at Cape Girardeau Municipal Airport (CGI) or Barkley Regional Airport (PAH).