Southeast Missouri Vacations 2025/2026 from CA $854

Southeast Missouri flight + hotel packages

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

CA $854

per person

Nov 17 - Nov 21

found 23 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

Stay at this 3.5-star business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient parking in our reviews. Popular attractions Six Flags St. Louis and Skid Row are located nearby.

The Cheshire

CA $1,159

per person

Nov 17 - Nov 21

found 23 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

Stay at this 4-star boutique hotel in Richmond Heights. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions St. Louis Union Station and Busch Stadium are located nearby.

Hampton Inn By Hilton St Louis Airport

Woodson Terrace

CA $1,009

per person

Nov 17 - Nov 21

found 23 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

Stay at this hotel in St. Louis. Enjoy free breakfast, free WiFi, and a free airport shuttle. Popular attractions Hollywood Casino Amphitheatre and Payne-Gentry Historical House are located nearby.

Sheraton Westport Plaza Hotel St. Louis

CA $1,452

per person

Nov 17 - Nov 21

found 23 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

Stay at this 3.5-star business-friendly hotel in Maryland Heights. Enjoy free parking, an outdoor pool, and breakfast (surcharge). Popular attractions Hollywood Casino Amphitheatre and Ameristar Casino St. Charles are located nearby.

Hilton Garden Inn Chesterfield

CA $873

per person

Nov 17 - Nov 21

found 23 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

Stay at this 3-star business-friendly hotel in Chesterfield. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions The J - Chesterfield Gym & Fitness Center and Topgolf are located nearby.

Top Southeast Missouri hotels deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive, Cape Girardeau, MO

Free cancellation

Reserve now, pay when you stay

CA $126

CA $142 total

Oct 26 - Oct 27

includes taxes & fees

Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center are located nearby.

Pool

Hot tub

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St, Farmington, MO

Free cancellation

Reserve now, pay when you stay

CA $79

CA $89 total

Oct 27 - Oct 28

includes taxes & fees

Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Wilson Rozier Park and Veterans Park are located nearby.

Pool

Breakfast included

The Riverview

777 Main St, Cape Girardeau, MO

Free cancellation

Reserve now, pay when you stay

CA $151

CA $171 total

Oct 19 - Oct 20

includes taxes & fees

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront Park are located nearby.

Parking included

Free WiFi

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3003 SOUTH OLD ORCHARD ROAD, Jackson, MO

Free cancellation

Reserve now, pay when you stay

CA $118

CA $128 total

Oct 23 - Oct 24

includes taxes & fees

Stay at this 3-star business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Cape Girardeau Conservation Nature Center and Lazy L Safari Park are located nearby.

Pool

Breakfast included

Motel 6 Poplar Bluff, MO

4101 Highway 67 N, Poplar Bluff, MO

Free cancellation

Reserve now, pay when you stay

CA $111

CA $117 total

Oct 23 - Oct 24

includes taxes & fees

Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located nearby.

Pet-friendly

Parking included

Comfort Inn Festus - St Louis South

1303 Veterans Blvd, Festus, MO

Free cancellation

Reserve now, pay when you stay

CA $112

CA $131 total

Nov 2 - Nov 3

includes taxes & fees

Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Sunset Park and Jorkerst Memorial Park are located nearby.

Breakfast included

Parking included

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Rocky Falls

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.

Lake Wappapello

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Frequently asked questions

How much are vacation packages to Southeast Missouri?

Packages, which include flights and hotels in Southeast Missouri, start at just CA $854. Make your travel dreams a reality and book your dream trip with Travelocity today.

Where can I get the best vacation package deals for Southeast Missouri?

There are fantastic Southeast Missouri package deals to score with Travelocity. Did you know we partner with as many as 400 airlines and 1,000,000 properties around the globe? Keep that in mind when you're ready to cross another place off your travel bucket list.

Why should I book my Southeast Missouri vacation package via Travelocity?

From incredible destinations to thrilling experiences, we have everything you need to satisfy your love for travel. Our 24/7 customer care will also ensure you're being taken care of before, during and after your trip. And don't panic if you notice a lower price on your booking, we'll match it. That's our Price Match Guarantee.

Will I save money on my Southeast Missouri car rental if I bundle it with my hotel or flight?

Absolutely. And our Southeast Missouri vacation packages are the perfect way to do it. With just a few clicks you can save cash as well as time by combining your bookings. Collect the keys to your rental car then set your own course. Looking for things to do? Add some tours or experiences to your package and make savings on those too.

Which airport is best for Southeast Missouri?

Cape Girardeau Municipal Airport (CGI) is the main airport that has flights in and out of Southeast Missouri.

What is there to do in Southeast Missouri?

Southeast Missouri has hidden gems around every corner, but make sure you visit Johnson's Shut-ins State Park and Meramec Caverns while you're here. These landmarks shouldn't be missed.