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Featured Syracuse 5 Star hotels
Grand Hotel Ortigia Siracusa
"one of the best hotels we have stayed at in recent memory. the room was comfortable and clean, the breakfasts were amazing, and the staff were so friendly and beyond helpful! highly recommend!"
Reviewed on Jul 2, 2026
Ortea Palace Hotel, Sicily, Autograph Collection
"Clean, good service, nice location"
Reviewed on Jun 23, 2026
Grand Hotel Des Ètrangers - The Leading Hotels of the World
"We stayed here for a few days whilst we were getting married nearby. The staff couldn’t have been more attentive from the minute we arrived with recommendations and helping arrange logistics. Fabio at the pool deck was fantastic and made us feel so looked after. Cannot rate highly enough. Stunning ..."
Reviewed on Jun 30, 2026
Minareto
"Minareto is truly an incredible property and a genuine five-star experience. The location is outstanding, with breathtaking views. Every member of the staff went above and beyond to make our stay exceptional, providing service that was warm, attentive, and genuinely welcoming. The property has incredible ..."
Reviewed on Jun 27, 2026
Caportigia Boutique Hotel
"Valentina was so very lovely and helpful. She was very informative as well. The property is very beautiful and a great location. My only criticism is the sound the doors make when you unlock the room door. It’s a very load electronic buzzing sound. Late at night you can hear other people coming in ..."
Reviewed on Jun 18, 2026
Dimora Caiammari Luxury Hotel & Spa
Wellness & Spa Hotel Principe di Fitalia
Five Star Hotels in Syracuse
Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Syracuse to make sure your trip is as extravagantly comfortable as you expect.
Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!
Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.
For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Syracuse 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.
Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Syracuse before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.
Recent Syracuse hotel reviews by fellow wanderers
Grand Hotel Ortigia Siracusa
"one of the best hotels we have stayed at in recent memory. the room was comfortable and clean, the breakfasts were amazing, and the staff were so friendly and beyond helpful! highly recommend!"
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