
Book Cheap American Airlines flight from Detroit (DTW) to Des Moines (DSM) from CA $754
Find The Best Day to Book a Cheap American Airlines Flights From Detroit to Des Moines
Cheapest American Airlines Flights from Detroit (DTW) to Des Moines (DSM)
The cheapest flights to Des Moines Intl. found within the past 7 days were round trip and CA $754 one way. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Grab a great American Airlines flight from DTW to DSM
To find a great deal on American Airlines flights with Travelocity, simply enter your origin and destination airports, pick your travel dates, and hit search. From here, you can sort by price, flight duration, and arrival/departure time. You can also filter to find nonstop flights.
Flying American Airlines Detroit to Des Moines gives you fights to choose from. With that direct flight time of , you’ll be touching down before you know it.
Find cheap flights with American Airlines between Detroit and Des Moines
American Airlines has a range of great fares on stacks of flights, and to find the most affordable for you, there are a few tricks you can try. Booking in advance, for example, is a great way to grab a fantastic deal. Also, choose the cheapest month, if you can. One-way flights from Detroit to Des Moines with American Airlines are December.
The more flexible you are, the more affordable flights you’re likely to find. Consider one-way flights and connecting flights, as well as standard roundtrip and direct options. Even if you’re flying today, cheap last-minute flights are easy to find by entering your travel dates and hitting search.
Reasons to book your American Airlines flights with Travelocity
Travelocity makes it easy to book a seat, anywhere in the world. The vast inventory, fast search, and advanced filters put some of the best deals on the planet in one place. Whether you’re traveling on business, with friends, family, or on your own, take your pick from some fantastic options. And with free cancellation and pay later options, you can travel more and worry less.
Airport code | Country | Airport name | Number of flights |
|---|---|---|---|
| DFW | USA | Dallas-Fort Worth Intl. | 599 |
| CLT | USA | Charlotte-Douglas Intl. | 536 |
| ORD | USA | O'Hare Intl. | 317 |
| PHL | USA | Philadelphia Intl. | 247 |
| MIA | USA | Miami Intl. | 193 |
| DCA | USA | Ronald Reagan Washington National | 152 |
| PHX | USA | Sky Harbor Intl. | 141 |
| LAX | USA | Los Angeles Intl. | 81 |
| LGA | USA | LaGuardia | 72 |
| BOS | USA | Logan Intl. | 57 |
Travelers ❤️ these 🏨 after their flight to Des Moines

Days Inn & Suites by Wyndham Des Moines Airport
Old outside appearance but when you get inside the room was like brand new. Super clean. Staff accommodated the hockey equipment of the boys. Great experience!
Reviewed on Dec 15, 2025

AmericInn by Wyndham Des Moines Airport
Room was clean enough
Reviewed on Dec 13, 2025

Quality Inn & Suites Des Moines Airport
Clean room - great staff.
Reviewed on Dec 12, 2025
Want more than a(n) American Airlines Flight from Detroit to Des Moines?
Popular American Airlines Flight Routes from DTW
Domestic
- Montreal to Punta Cana (YUL - PUJ)
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- Toronto to Montego Bay (YYZ - MBJ)
- Toronto to Fort Lauderdale (YYZ - FLL)
- Toronto to London (YYZ - LHR)
- Montreal to Miami (YUL - MIA)
- Vancouver to Delhi (YVR - DEL)
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International
- Montreal to Cancun (YUL - CUN)
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- Toronto to London (YYZ - LHR)
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