
Book Cheap American Airlines flight from Detroit (DTW) to Key West (EYW) from CA $716
Find The Best Day to Book a Cheap American Airlines Flights From Detroit to Key West
Cheapest American Airlines Flights from Detroit (DTW) to Key West (EYW)
The cheapest flights to Key West Intl. found within the past 7 days were CA $558 round trip and CA $716 one way. Prices and availability subject to change. Additional terms may apply.
EYW From DTW Economy Coach Packages on Similar Airlines



Grab a great American Airlines flight from DTW to EYW
To find a great deal on American Airlines flights with Travelocity, simply enter your origin and destination airports, pick your travel dates, and hit search. From here, you can sort by price, flight duration, and arrival/departure time. You can also filter to find nonstop flights.
Flying American Airlines Detroit to Key West gives you fights to choose from. With that direct flight time of , you’ll be touching down before you know it.
Find cheap flights with American Airlines between Detroit and Key West
American Airlines has a range of great fares on stacks of flights, and to find the most affordable for you, there are a few tricks you can try. Booking in advance, for example, is a great way to grab a fantastic deal. Also, choose the cheapest month, if you can. One-way flights from Detroit to Key West with American Airlines are December.
The more flexible you are, the more affordable flights you’re likely to find. Consider one-way flights and connecting flights, as well as standard roundtrip and direct options. Even if you’re flying today, cheap last-minute flights are easy to find by entering your travel dates and hitting search.
Reasons to book your American Airlines flights with Travelocity
Travelocity makes it easy to book a seat, anywhere in the world. The vast inventory, fast search, and advanced filters put some of the best deals on the planet in one place. Whether you’re traveling on business, with friends, family, or on your own, take your pick from some fantastic options. And with free cancellation and pay later options, you can travel more and worry less.
Airport code | Country | Airport name | Number of flights |
|---|---|---|---|
| DFW | USA | Dallas-Fort Worth Intl. | 599 |
| CLT | USA | Charlotte-Douglas Intl. | 536 |
| ORD | USA | O'Hare Intl. | 317 |
| PHL | USA | Philadelphia Intl. | 247 |
| MIA | USA | Miami Intl. | 193 |
| DCA | USA | Ronald Reagan Washington National | 152 |
| PHX | USA | Sky Harbor Intl. | 141 |
| LAX | USA | Los Angeles Intl. | 81 |
| LGA | USA | LaGuardia | 72 |
| BOS | USA | Logan Intl. | 57 |
Travelers ❤️ these 🏨 after their flight to Key West

Hyatt Vacation Club at Windward Pointe, Key West
Clean room great staff beautiful hotel and very spacious rooms.
Reviewed on Nov 14, 2025

Hampton Inn Key West FL
Everything was perfect! Great customer service everywhere and great breakfast and food at tiki bar
Reviewed on Nov 11, 2025

DoubleTree Resort by Hilton Grand Key - Key West
The staff was very pleasant and helpful. The grounds and hotel were very clean. The construction noise was very annoying. Couldnt relax around the pool because a saw was constantly in use.
Reviewed on Nov 15, 2025
Want more than a(n) American Airlines Flight from Detroit to Key West?
Popular American Airlines Flight Routes from DTW
Domestic
- Toronto to Sri Guru Ram Das Ji Intl. Airport (YYZ - ATQ)
- Toronto to New York (YYZ - JFK)
- Toronto to Orlando (YYZ - MCO)
- Toronto to Ahmedabad (YYZ - AMD)
- Toronto to Mumbai (YYZ - BOM)
- Toronto to Karachi (YYZ - KHI)
- Montreal to Fort Lauderdale (YUL - FLL)
- Montreal to Paris (YUL - CDG)
- Toronto to Fort Lauderdale (YYZ - FLL)
- Toronto to London (YYZ - LHR)
International
- Calgary to Delhi (YYC - DEL)
- Vancouver to Delhi (YVR - DEL)
- Toronto to Fort Lauderdale (YYZ - FLL)
- Toronto to Cancun (YYZ - CUN)
- Toronto to Karachi (YYZ - KHI)
- Toronto to New York (YYZ - JFK)
- Toronto to Delhi (YYZ - DEL)
- Toronto to Orlando (YYZ - MCO)
- Toronto to New York (YYZ - LGA)
- Toronto to Lisbon (YYZ - LIS)
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