Cheap Flight Deals to Santa Cruz S from CA $172

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How to find cheap flights to Santa Cruz?

The cheapest prices found with in the last 7 days for return flights were CA $333 and CA $172 for one-way flights to Santa Cruz for the period specified. Prices and availability are subject to change. Additional terms apply

OriginDestinationTravel datesFlights from*
SCLSanta CruzJune 19 to June 23CA $752
SCLSanta CruzJune 19 to June 23CA $752
MIASanta CruzAugust 5 to August 9CA $880
MEXSanta CruzJuly 10 to July 18CA $1,075
MEXSanta CruzJuly 10 to July 18CA $1,075
IADSanta CruzJune 20 to July 4CA $1,176
IADSanta CruzJune 20 to July 4CA $1,176
IAHSanta CruzAugust 27 to September 5CA $1,252
IAHSanta CruzAugust 27 to September 5CA $1,252
PTYSanta CruzJune 19 to June 24CA $1,308
PTYSanta CruzJune 19 to June 24CA $1,308
LAXSanta CruzJune 20 to June 29CA $1,368
LAXSanta CruzJune 20 to June 29CA $1,368
FCOSanta CruzJune 23 to July 29CA $1,976
FCOSanta CruzJune 23 to July 29CA $1,976
*Prices include taxes and fees

Your guide to flights to Santa Cruz, S

Boliviana De Aviacion, WestJet, avianca fly to Santa Cruz, so use Travelocity to search, find, and compare some truly tempting deals from the 4 airlines—that way you can be sure you’ve found the best deal for you. A flight to Santa Cruz S currently costs between CA $333 and CA $1,976. Prices vary, but for the best fares, travel in February when prices are at their lowest.  

Top tips for finding cheap flights to Santa Cruz  

The cheapest flight for a round trip to Santa Cruz is currently CA $333. When you search for flights to Santa Cruz, enter your preferred travel dates then click on ‘flexible dates’ to compare cheap flight tickets to Santa Cruz for nearby days.  The cheapest month to travel to Santa Cruz is February from our list of deals available.  

But if you’re flexible about when you travel, you can find great deals on flights across the year. If you’re planning a vacation, you can save more on Travelocity when you bundle flights with car rental and hotel bookings, too. Many airlines currently offer flexible booking options, so look for flights offering no change fees.   

How to cancel flights to Santa Cruz 

We know plans change, that’s why at Travelocity, we make it as easy as possible for you to cancel or amend your plane tickets. Go to My Trips, enter your itinerary number, then follow the instructions. Many airlines let you cancel flights online free of charge if you booked it in the last 24 hours. Visit Customer Service for more advice.  

Why you should book your flight to Santa Cruz with Travelocity 

We have top deals on plane tickets even for last minute flights to Santa Cruz, so you can simply type in your travel dates and compare our best prices. Booking with Travelocity means you get flexible cancellation options, 24/7 support, and, thanks to our Price Match Promise, if the airfare drops after you book, you can get a refund! Whether you’re planning a business trip, weekend getaway, or a family vacation—let Travelocity get you to Santa Cruz for less. 

Find The Perfect Hotel For After Your Flight

Amazing Place to Stay After Flight to Santa Cruz

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is CA $177 per night from Jun 12 to Jun 13
CA $177
CA $177 total
Jun 12 - Jun 13
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9/10 Wonderful! (381 reviews)
"The stuff they have excellent customer service"

Reviewed on May 29, 2026

Opens in a new windowLos Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Hotel LP Equipetrol

Hotel LP Equipetrol

3.5 out of 5
Dr Victor Pinto, Equipetrol Santa Cruz
The price is CA $60 per night from Jun 9 to Jun 10
CA $60
CA $67 total
Jun 9 - Jun 10
Stay at this hotel in Santa Cruz. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions Ventura Mall and Santa Cruz Zoo are located ...
Opens in a new windowHotel LP Equipetrol
Yotau All Suites Hotel

Yotau All Suites Hotel

3.5 out of 5
Av. San Martin No. 7 Santa Cruz
The price is CA $157 per night from Jun 9 to Jun 10
CA $157
CA $157 total
Jun 9 - Jun 10
Book a stay at this family-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Patio Design LifeStyle Center ...
7/10 Good! (76 reviews)
"My issue was because the property inside the room was old needs a lot maintenance I found a underwear en the cabinet in the bathroom"

Reviewed on Aug 3, 2025

Opens in a new windowYotau All Suites Hotel
Save an average of 15% on thousands of hotels when you're signed in
Hotel LP Santa Cruz Centro

Hotel LP Santa Cruz Centro

3 out of 5
Av.Ejercito Nacional 290 Santa Cruz
The price is CA $66 per night from Jun 13 to Jun 14
CA $66
CA $73 total
Jun 13 - Jun 14
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Ramon Tahuichi Aguilera ...
8/10 Very Good! (285 reviews)
"Awesome hotel"

Reviewed on Feb 6, 2026

Opens in a new windowHotel LP Santa Cruz Centro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our Top Santa Cruz hotel with Airport Shuttles

Casa Vida

Casa Vida

3.5 out of 5
Condominio Club Campestre Santa Cruz Santa
The price is CA $126 per night from Jun 9 to Jun 10
CA $126
CA $126 total
Jun 9 - Jun 10
Book a stay at this family-friendly vacation home in Santa Cruz. Enjoy free WiFi, free parking, and private hot tubs.
9/10 Wonderful! (2 reviews)
"buena recepción, el lugar es muy bueno un poco alejado de la ciudad, falta comodidad en algunos aspectos pero la casa es grande y espaciosa"

Reviewed on Sep 28, 2017

Opens in a new windowCasa Vida
Sun Hotel

Sun Hotel

3.5 out of 5
Av. Banzer Km 13 Santa Cruz Santa Cruz
The price is CA $151 per night from Jun 9 to Jun 10
CA $151
CA $151 total
Jun 9 - Jun 10
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Play Land Amusement Park is ...
8.2/10 Very Good! (379 reviews)
"Very well located three start hotel. Clean with everything you need for an in/out night. Hotel needs a redoing."

Reviewed on May 27, 2026

Opens in a new windowSun Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Santa Cruz

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is CA $177 per night from Jun 12 to Jun 13
CA $177
CA $177 total
Jun 12 - Jun 13
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9/10 Wonderful! (381 reviews)
"The stuff they have excellent customer service"

Reviewed on May 29, 2026

Opens in a new windowLos Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Santa Cruz

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is CA $177 per night from Jun 12 to Jun 13
CA $177
CA $177 total
Jun 12 - Jun 13
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9/10 Wonderful! (381 reviews)
"The stuff they have excellent customer service"

Reviewed on May 29, 2026

Opens in a new windowLos Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45 Santa Cruz
The price is CA $38 per night from Jun 9 to Jun 10
CA $38
CA $38 total
Jun 9 - Jun 10
Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle Center ...
8.6/10 Excellent! (102 reviews)
"Great location."

Reviewed on Jun 4, 2026

Opens in a new windowApart Hotel Premium Suites Santa Cruz
Buganvillas Hotel Suites & Spa

Buganvillas Hotel Suites & Spa

4 out of 5
Av. Roca y Coronado No. 901 Santa Cruz
Book a stay at this family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...
Opens in a new windowBuganvillas Hotel Suites & Spa
Save an average of 15% on thousands of hotels when you're signed in
Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo Santa Cruz
The price is CA $220 per night from Jun 10 to Jun 11
CA $220
CA $220 total
Jun 10 - Jun 11
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Centro Cultural ...
9/10 Wonderful! (428 reviews)
"Definitely I would’ve recommend anybody who is looking for hotel because the service was excellent make me feel special since I walked in into the place and also I was impressed how clean the place was…Thanks for the service guys…Keep up this way..thanks again for everything…I’ll see you soon.🙏"

Reviewed on May 31, 2026

Opens in a new windowCamino Real Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best Santa Cruz Flight and Hotel Packages

Santa Cruz flight + hotel packages - economy flights

Price found within the past 48 hours. Click for updated prices.
Swissôtel Santa Cruz De La Sierra
Camino Real Hotel
Hotel Cortez
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Need a car after flight to Santa Cruz?

Frequently asked questions

Which airlines fly to Santa Cruz?
10 carriers fly to Santa Cruz, which means you won't be short on choice. Experienced travelers often recommend:

  • BoA
  • Amaszonas
  • Copa Airlines

What airport is best to fly into Santa Cruz?
There's no need to research flight options into different airports when traveling to Santa Cruz. VVI is the city's only airport, and is located 16 kilometers from the downtown area.
Where to stay in Santa Cruz
Choosing the perfect place to stay is a key ingredient for an unforgettable travel experience. Select from 174 properties in Santa Cruz and start planning the adventure of your dreams!There's no more suitable time to truly spoil yourself than when you're taking a vacation. Lock in a room at the Los Tajibos Hotel And Convention Center and enjoy a taste of the high life during your stay. Traveling with a smaller budget? Don't worry, you won't be left out in the cold. The Casa Internacional Los Aventureros will keep you and your hip-pocket happy.
Places to visit in Santa Cruz
0 Need some more options? 0 But that's not all there is. 0
How to get through airport security fast when traveling to Santa Cruz
If you like the idea of spending more time at the airport restaurants and less time wading through security on your way to Santa Cruz, follow these practical tips:

  • Be sure you know the whereabouts of your travel ID and boarding pass. You don't want to hold up the queue when you're asked to hand them over.
  • Bear in mind that belts with metal buckles can set off the body scanner's alarms. If you have one on, you may be instructed to remove it before continuing.
  • Laptops, digital cameras and other electronic devices must be placed in a tub to be X-rayed.
  • Toothpaste, lip balm and other toiletry items in liquid, gel or cream form need to be stored in containers no larger than 3.4 ounces (100 milliliters). They must also fit in a 1-quart (1-liter) clear zip-lock plastic bag.
  • Consider your choice of footwear. Slippers are great because they're a cinch to step out of when you're doing the airport security checks. Try wearing some on your next journey!
  • Some places have stringent biosecurity laws. Consider where you're off to and whether or not it's permissible to fly with fresh fruit.

Plane Tickets To Santa Cruz

Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Santa Cruz. Browse through our inventory to explore a wide range of cheap flights to Santa Cruz to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Santa Cruz as you anxiously await to exit the plane and explore what Santa Cruz has to offer. Considering all the amazing local food and culture in Santa Cruz, we won't hold this against you.

When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Santa Cruz to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Santa Cruz without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Santa Cruz with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Santa Cruz today!

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*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.