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Your guide to flights to Santa Cruz, S

GOL Linhas Aereas S.A., Boliviana De Aviacion, WestJet, avianca fly to Santa Cruz, so use Travelocity to search, find, and compare some truly tempting deals from the 4 airlines—that way you can be sure you’ve found the best deal for you. A flight to Santa Cruz S currently costs between CA $437 and CA $1,976. Prices vary, but for the best fares, travel in June when prices are at their lowest.  

Top tips for finding cheap flights to Santa Cruz  

The cheapest flight for a round trip to Santa Cruz is currently CA $437. When you search for flights to Santa Cruz, enter your preferred travel dates then click on ‘flexible dates’ to compare cheap flight tickets to Santa Cruz for nearby days.  The cheapest month to travel to Santa Cruz is September from our list of deals available.  

But if you’re flexible about when you travel, you can find great deals on flights across the year. If you’re planning a vacation, you can save more on Travelocity when you bundle flights with car rental and hotel bookings, too. Many airlines currently offer flexible booking options, so look for flights offering no change fees.   

How to cancel flights to Santa Cruz 

We know plans change, that’s why at Travelocity, we make it as easy as possible for you to cancel or amend your plane tickets. Go to My Trips, enter your itinerary number, then follow the instructions. Many airlines let you cancel flights online free of charge if you booked it in the last 24 hours. Visit Customer Service for more advice.  

Why you should book your flight to Santa Cruz with Travelocity 

We have top deals on plane tickets even for last minute flights to Santa Cruz, so you can simply type in your travel dates and compare our best prices. Booking with Travelocity means you get flexible cancellation options, 24/7 support, and, thanks to our Price Match Promise, if the airfare drops after you book, you can get a refund! Whether you’re planning a business trip, weekend getaway, or a family vacation—let Travelocity get you to Santa Cruz for less. 

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is CA $177 per night from Jun 27 to Jun 28
CA $177
CA $177 total
Jun 27 - Jun 28
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9/10 Wonderful! (381 reviews)
"The stuff they have excellent customer service"

Reviewed on May 29, 2026

Opens in a new windowLos Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Hotel LP Equipetrol

Hotel LP Equipetrol

3.5 out of 5
Dr Victor Pinto, Equipetrol Santa Cruz
The price is CA $55 per night from Jun 13 to Jun 14
CA $55
CA $62 total
Jun 13 - Jun 14
Stay at this hotel in Santa Cruz. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions Ventura Mall and Santa Cruz Zoo are located ...
Opens in a new windowHotel LP Equipetrol
Yotau All Suites Hotel

Yotau All Suites Hotel

3.5 out of 5
Av. San Martin No. 7 Santa Cruz
The price is CA $157 per night from Jun 11 to Jun 12
CA $157
CA $157 total
Jun 11 - Jun 12
Book a stay at this family-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Patio Design LifeStyle Center ...
7/10 Good! (76 reviews)
"My issue was because the property inside the room was old needs a lot maintenance I found a underwear en the cabinet in the bathroom"

Reviewed on Aug 3, 2025

Opens in a new windowYotau All Suites Hotel
Save an average of 15% on thousands of hotels when you're signed in
Hotel LP Santa Cruz Centro

Hotel LP Santa Cruz Centro

3 out of 5
Av.Ejercito Nacional 290 Santa Cruz
The price is CA $74 per night from Jun 11 to Jun 12
CA $74
CA $81 total
Jun 11 - Jun 12
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Ramon Tahuichi Aguilera ...
8/10 Very Good! (285 reviews)
"Awesome hotel"

Reviewed on Feb 6, 2026

Opens in a new windowHotel LP Santa Cruz Centro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Casa Vida

Casa Vida

3.5 out of 5
Condominio Club Campestre Santa Cruz Santa
The price is CA $126 per night from Jun 18 to Jun 19
CA $126
CA $126 total
Jun 18 - Jun 19
Book a stay at this family-friendly vacation home in Santa Cruz. Enjoy free WiFi, free parking, and private hot tubs.
9/10 Wonderful! (2 reviews)
"buena recepción, el lugar es muy bueno un poco alejado de la ciudad, falta comodidad en algunos aspectos pero la casa es grande y espaciosa"

Reviewed on Sep 28, 2017

Opens in a new windowCasa Vida
Sun Hotel

Sun Hotel

3.5 out of 5
Av. Banzer Km 13 Santa Cruz Santa Cruz
The price is CA $151 per night from Jun 14 to Jun 15
CA $151
CA $151 total
Jun 14 - Jun 15
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Play Land Amusement Park is ...
8.2/10 Very Good! (379 reviews)
"Very well located three start hotel. Clean with everything you need for an in/out night. Hotel needs a redoing."

Reviewed on May 27, 2026

Opens in a new windowSun Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is CA $177 per night from Jun 27 to Jun 28
CA $177
CA $177 total
Jun 27 - Jun 28
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9/10 Wonderful! (381 reviews)
"The stuff they have excellent customer service"

Reviewed on May 29, 2026

Opens in a new windowLos Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is CA $177 per night from Jun 27 to Jun 28
CA $177
CA $177 total
Jun 27 - Jun 28
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9/10 Wonderful! (381 reviews)
"The stuff they have excellent customer service"

Reviewed on May 29, 2026

Opens in a new windowLos Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45 Santa Cruz
The price is CA $38 per night from Jun 11 to Jun 12
CA $38
CA $38 total
Jun 11 - Jun 12
Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle Center ...
8.6/10 Excellent! (102 reviews)
"Great location."

Reviewed on Jun 4, 2026

Opens in a new windowApart Hotel Premium Suites Santa Cruz
Buganvillas Hotel Suites & Spa

Buganvillas Hotel Suites & Spa

4 out of 5
Av. Roca y Coronado No. 901 Santa Cruz
Book a stay at this family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...
Opens in a new windowBuganvillas Hotel Suites & Spa
Save an average of 15% on thousands of hotels when you're signed in
Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo Santa Cruz
The price is CA $220 per night from Jun 16 to Jun 17
CA $220
CA $220 total
Jun 16 - Jun 17
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Centro Cultural ...
9/10 Wonderful! (428 reviews)
"Definitely I would’ve recommend anybody who is looking for hotel because the service was excellent make me feel special since I walked in into the place and also I was impressed how clean the place was…Thanks for the service guys…Keep up this way..thanks again for everything…I’ll see you soon.🙏"

Reviewed on May 31, 2026

Opens in a new windowCamino Real Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.