Eastern Panama Vacations 2026 from CA $727

Eastern Panama flight + hotel packages

Price found within the past 48 hours. Click for updated prices.

MARINN PLACE Financial District

Bella Vista

CA $727

per person

Jun 3 - Jun 6

found 2 days ago

Roundtrip non-stop flight included

Cancun (CUN) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Megapolis Hotel Panamá

San Francisco

CA $813

per person

Jun 3 - Jun 6

found 2 days ago

Roundtrip non-stop flight included

Cancun (CUN) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Dreams Playa Bonita Panama - All Inclusive

CA $1,012

per person

Jun 3 - Jun 6

found 2 days ago

Roundtrip non-stop flight included

Cancun (CUN) to Panama City (PTY)

Book a stay at this beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Amador Causeway are located nearby.

Mini Design By Wynwood House

Bella Vista

CA $1,474

per person

Jul 1 - Jul 8

found 22 hours ago

Roundtrip non-stop flight included

Montreal (YUL) to Panama City (PTY)

Stay at this apartment in Panama City. Enjoy free WiFi, air conditioning, and an outdoor pool. Popular attractions Albrook Shopping Mall and Multiplaza Pacific Mall are located nearby.

Wanders Panama by Boutique Apartments

San Francisco

CA $2,178

per person

Jun 3 - Jun 6

found 2 days ago

Roundtrip non-stop flight included

Cancun (CUN) to Panama City (PTY)

Book a stay at this spa apartment in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Top Eastern Panama hotels deals

Ciel y Miel

Caillle Principale Cacique Provincia de Colón

CA $282

CA $310 total

May 5 - May 6

includes taxes & fees

Book a stay at this beach hotel in Cacique. Enjoy free breakfast, free WiFi, and free valet parking. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

Pool

Breakfast included

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island Narganá Guna Yala

Get rates

Stay at this hotel in San Blas Islands. Enjoy free breakfast, an airport shuttle (surcharge), and a garden. Popular attractions Isla Diablo and Isla Chichime are located nearby.

Breakfast included

Restaurant

Ordovician Beach Resort

Isla Grande Isla Grande Colon

CA $615

CA $683 total

May 19 - May 20

includes taxes & fees

Book a stay at this luxury resort in Isla Grande. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

On private beach

Pool

HOTEL ISLA GRANDE

Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province

CA $151

CA $166 total

May 5 - May 6

includes taxes & fees

Book a stay at this beach hotel in Isla Grande. Enjoy free breakfast, a beach locale, and onsite spa services. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

Breakfast included

Spa

Cocoloco - Catamaran Lagoon 52F SAN BLAS

El Porvenir Narganá Guna Yala

Free cancellation

Reserve now, pay when you stay

CA $2,717

CA $2,996 total

May 6 - May 7

includes taxes & fees

Book a stay at this beach property in San Blas Islands. Enjoy free breakfast, free WiFi, and a beach locale. Popular attractions Porvenir Museum and Isla Chichime are located nearby.

Breakfast included

Free WiFi

Konsenda San Blas

Llano Cartí Km 11 El Llano Panamá Province

Free cancellation

Reserve now, pay when you stay

CA $83

CA $92 total

May 6 - May 7

includes taxes & fees

Stay at this hotel in El Llano. Enjoy free breakfast, free parking, and a garden.

Breakfast included

Parking included

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Isla Diablo

Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area.

Isla Chichime

Commune with nature and explore the great outdoors at Isla Chichime during your travels in San Blas Islands. Take in the festivals while you're in the area.

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Narganá. Stroll along the seaside or experience the area's festivals.

Frequently asked questions

How much are vacation packages to Eastern Panama?

Exciting adventures await in Eastern Panama, with Travelocity vacation packages starting from as low as CA $727. Including flights and hotels, these awesome deals make it a breeze to see more of our beautiful planet.

Where can I get the best vacation package deals for Eastern Panama?

You can snap up amazing Eastern Panama package deals with Travelocity. Mix and match from 400 air carriers and 1,000,000 worldwide properties and turn those travel dreams into a reality.

Why should I purchase my Eastern Panama vacation package with Travelocity?

We offer 24/7 support, top-quality service and a Price Match Guarantee. Life's a great big journey — and we have alluring destinations for you to journey to all across the world. Wander with us and your wallet will thank you for it.

Can I save money on my Eastern Panama car rental if I bundle it with my hotel or flight?

Certainly. And our Eastern Panama vacation packages are the perfect way to do it. In just a few clicks you can save cash as well as time by bundling your bookings. Pick up the keys to your rental car and feel the freedom of the open road. Searching for things to do? Add some tours or experiences to your package and make savings on those too.

What is there to do in Eastern Panama?

You'll be happy to know Eastern Panama is brimming with incredible things to see and do, however Isla Mamey and Cayos Holandeses are right up there with the very best.