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Most frequently booked O Brien hotels

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
obrien FL
14.67 km from city centre
Book a stay at this beach vacation home in O Brien. Enjoy free WiFi, a beach locale, and a fitness center. Popular attractions Wes Skiles Peacock Springs State Park and Telford Spring are located nearby.
Kitchen
Washer

La Quinta Inn & Suite by Wyndham Lake City
165NW CALI DRIVE Lake City FL
Free cancellation
Reserve now, pay when you stay
29.34 km from city centre
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Regal UA Cinema 90 and Lake City Mall are located nearby.
Pool
Breakfast included

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
1699 NE Co Rd 337 High Springs FL
39.7 km from city centre
Stay at this cabin in High Springs. Enjoy free parking, patios, and climate control. Popular attractions Ruth B. Kirby Gilchrist Blue Springs State Park and Poe Springs Park are located nearby.
Kitchen
Pet-friendly

Tru by Hilton Lake City
284 NW Centurion Court Lake City FL
Free cancellation
Reserve now, pay when you stay
28.85 km from city centre
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Regal UA Cinema 90 and Lake City Mall are located nearby.
Pool
Breakfast included

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
16367 NW 167TH BLVD Alachua FL
Free cancellation
48.18 km from city centre
Book a stay at this business-friendly hotel in Alachua. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Alachua Sports Complex and City of Alachua Recreation and Community Center are located nearby.
Pool
Hot tub

Best Western Plus Lake City
350 SW Florida Gateway Dr Lake City FL
Free cancellation
Reserve now, pay when you stay
28.81 km from city centre
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Regal UA Cinema 90 and Lake City Mall are located nearby.
Pool
Breakfast included

Motel 6 – Lake City, Fl – Medical Center
3340 W US Highway 90 Lake City FL
Free cancellation
Reserve now, pay when you stay
28.99 km from city centre
Stay at this motel in Lake City. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Regal UA Cinema 90 and Lake City Mall are located nearby.
Pet-friendly
Parking included

Hampton Inn & Suites Lake City
450 SW Florida Gateway Drive Lake City FL
Free cancellation
Reserve now, pay when you stay
28.72 km from city centre
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Regal UA Cinema 90 and Lake City Mall are located nearby.
Pool
Breakfast included

Holiday Inn Express & Suites Live Oak by IHG
6694 Us Highway 129 Live Oak FL
Free cancellation
32.24 km from city centre
Book a stay at this business-friendly hotel in Live Oak. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Suwannee County Historical Museum and First Federal Sportsplex are located nearby.
Pool
Breakfast included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
O Brien hotels essential information
Accommodation | 351 hotels |
|---|---|
Lowest Price | |
Highest Price | |
Popular hotels | Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!, La Quinta Inn & Suite by Wyndham Lake City, Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy, Tru by Hilton Lake City, Holiday Inn Express & Suites Alachua - Gainesville Area by IHG, Best Western Plus Lake City, Motel 6 – Lake City, Fl – Medical Center, Hampton Inn & Suites Lake City, Holiday Inn Express & Suites Live Oak by IHG |
Frequently asked questions
Recent O Brien hotel reviews by fellow wanderers

Motel 6 – Lake City, Fl – Medical Center
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"This was definitely a nicer Motel 6 ! The room was clean , the beds comfy and plenty of area outside for my dogs! There is an IHOP in front and Cracker Barrel behind it for breakfast! Lots of other options for dinner. Very close to 75 . Definitely recommend! "
A verified traveller stayed at Motel 6 – Lake City, Fl – Medical Center
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