Southeast Missouri Vacations 2026/2026 from CA $771

Southeast Missouri flight + hotel packages

Price found within the past 48 hours. Click for updated prices.

The West End

Central West End

CA $771

per person

Jan 8 - Jan 13

found 11 hours ago

Roundtrip flight included

Toronto (YYZ) to St. Louis (STL)

Stay at this hotel in St. Louis. Enjoy free WiFi, a 24-hour fitness center, and parking (surcharge). Popular attractions St. Louis Union Station and Gateway Arch are located nearby.

Comfort Suites Rolla

CA $985

per person

Feb 14 - Feb 21

found 20 hours ago

Roundtrip non-stop flight included

Ottawa (YOW) to St. Louis (STL)

Book a stay at this business-friendly hotel in Rolla. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Allgood-Bailey Stadium and Lions Club Park are located nearby.

Comfort Inn Sullivan

CA $947

per person

Feb 14 - Feb 21

found 20 hours ago

Roundtrip non-stop flight included

Ottawa (YOW) to St. Louis (STL)

Book a stay at this business-friendly hotel in Sullivan. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Sullivan Country Club and Meramec State Park are located nearby.

White House at Grand Central

Grand Center

CA $772

per person

Jan 8 - Jan 13

found 11 hours ago

Roundtrip flight included

Toronto (YYZ) to St. Louis (STL)

Stay at this apartment in St. Louis. Enjoy free WiFi, a 24-hour front desk, and a garden. Popular attractions St. Louis Union Station and Gateway Arch are located nearby.

The Cheshire

CA $1,042

per person

Jan 8 - Jan 13

found 11 hours ago

Roundtrip flight included

Toronto (YYZ) to St. Louis (STL)

Book a stay at this boutique hotel in Richmond Heights. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions St. Louis Union Station and St. Louis Zoo are located nearby.

Top Southeast Missouri hotels deals

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Free cancellation

Reserve now, pay when you stay

CA $76

CA $86 total

Dec 11 - Dec 12

includes taxes & fees

Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Wilson Rozier Park and Veterans Park are located nearby.

Pool

Breakfast included

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Free cancellation

Reserve now, pay when you stay

CA $126

CA $142 total

Dec 17 - Dec 18

includes taxes & fees

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center are located nearby.

Pool

Hot tub

The Riverview

777 Main St Cape Girardeau MO

Free cancellation

Reserve now, pay when you stay

CA $134

CA $152 total

Dec 17 - Dec 18

includes taxes & fees

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront Park are located nearby.

Parking included

Free WiFi

Baymont by Wyndham Festus

1200 W. Gannon Drive Festus MO

Free cancellation

Reserve now, pay when you stay

CA $107

CA $122 total

Dec 7 - Dec 8

includes taxes & fees

Book a stay at this family-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Jorkerst Memorial Park and Sunset Park are located nearby.

Pool

Breakfast included

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

Free cancellation

Reserve now, pay when you stay

CA $106

CA $112 total

Dec 7 - Dec 8

includes taxes & fees

Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located nearby.

Pet-friendly

Parking included

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3003 SOUTH OLD ORCHARD ROAD Jackson MO

Free cancellation

Reserve now, pay when you stay

CA $109

CA $118 total

Jan 5 - Jan 6, 2026

includes taxes & fees

Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Cape Girardeau Conservation Nature Center and Lazy L Safari Park are located nearby.

Pool

Breakfast included

Don't see what you're looking for?

See all available properties in Southeast Missouri

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Lake Wappapello

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

Frequently asked questions

How much are vacation packages to Southeast Missouri?

Packages, which include flights and hotels in Southeast Missouri, start at just CA $771. Make your travel dreams a reality and book your dream trip with Travelocity today.

Where can I get the best vacation package deals for Southeast Missouri?

There are fantastic Southeast Missouri package deals to score with Travelocity. Did you know we partner with as many as 400 airlines and 1,000,000 properties around the globe? Keep that in mind when you're ready to cross another place off your travel bucket list.

Why should I book my Southeast Missouri vacation package via Travelocity?

From incredible destinations to thrilling experiences, we have everything you need to satisfy your love for travel. Our 24/7 customer care will also ensure you're being taken care of before, during and after your trip. And don't panic if you notice a lower price on your booking, we'll match it. That's our Price Match Guarantee.

Will I save money on my Southeast Missouri car rental if I bundle it with my hotel or flight?

Absolutely. And our Southeast Missouri vacation packages are the perfect way to do it. With just a few clicks you can save cash as well as time by combining your bookings. Collect the keys to your rental car then set your own course. Looking for things to do? Add some tours or experiences to your package and make savings on those too.

Which airport is best for Southeast Missouri?

Cape Girardeau Municipal Airport (CGI) is the main airport that has flights in and out of Southeast Missouri.

What is there to do in Southeast Missouri?

Southeast Missouri has hidden gems around every corner, but make sure you visit Johnson's Shut-ins State Park and Meramec Caverns while you're here. These landmarks shouldn't be missed.