Southeast Missouri Vacations 2026

Top Southeast Missouri hotels deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Free cancellation

Reserve now, pay when you stay

CA $140

CA $158 total

Nov 3 - Nov 4

includes taxes & fees

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center are located nearby.

Pool

Hot tub

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO

Free cancellation

Reserve now, pay when you stay

CA $126

CA $141 total

Nov 8 - Nov 9

includes taxes & fees

Stay at this hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Poplar Bluff History Museum and North Main Street Historic District are located nearby.

Pool

Breakfast included

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Free cancellation

Reserve now, pay when you stay

CA $131

CA $151 total

Nov 8 - Nov 9

includes taxes & fees

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Central Park and Sikeston Depot Museum are located nearby.

Pool

Breakfast included

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Free cancellation

Reserve now, pay when you stay

CA $76

CA $87 total

Nov 8 - Nov 9

includes taxes & fees

Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Farmington Water Park and Wilson Rozier Park are located nearby.

Pool

Breakfast included

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

Free cancellation

Reserve now, pay when you stay

CA $101

CA $114 total

Nov 8 - Nov 9

includes taxes & fees

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Cape Splash Family Aquatic Center and Fort D Historic Site are located nearby.

Breakfast included

Pet-friendly

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

Free cancellation

Reserve now, pay when you stay

CA $93

CA $106 total

Nov 30 - Dec 1

includes taxes & fees

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Central Park and Sikeston Depot Museum are located nearby.

Breakfast included

Pet-friendly

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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Frequently asked questions

How much are vacation packages to Southeast Missouri?

Packages, which include flights and hotels in Southeast Missouri, start at just . Make your travel dreams a reality and book your dream trip with Travelocity today.

Where can I get the best vacation package deals for Southeast Missouri?

There are fantastic Southeast Missouri package deals to score with Travelocity. Did you know we partner with as many as 400 airlines and 1,000,000 properties around the globe? Keep that in mind when you're ready to cross another place off your travel bucket list.

Why should I book my Southeast Missouri vacation package via Travelocity?

From incredible destinations to thrilling experiences, we have everything you need to satisfy your love for travel. Our 24/7 customer care will also ensure you're being taken care of before, during and after your trip. And don't panic if you notice a lower price on your booking, we'll match it. That's our Price Match Guarantee.

Will I save money on my Southeast Missouri car rental if I bundle it with my hotel or flight?

Absolutely. And our Southeast Missouri vacation packages are the perfect way to do it. With just a few clicks you can save cash as well as time by combining your bookings. Collect the keys to your rental car then set your own course. Looking for things to do? Add some tours or experiences to your package and make savings on those too.

Which airport is best for Southeast Missouri?

Cape Girardeau Municipal Airport (CGI) is the main airport that has flights in and out of Southeast Missouri.

What is there to do in Southeast Missouri?

Southeast Missouri has hidden gems around every corner, but make sure you visit Johnson's Shut-ins State Park and Meramec Caverns while you're here. These landmarks shouldn't be missed.