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Top Cairo hotels deals

Quality Inn Cairo I-57

Quality Inn Cairo I-57

2.5 out of 5
13201 Kessler Road, Cairo, IL
Free cancellation
Reserve now, pay when you stay
The price is CA $104 per night
CA $104
per night
Jun. 16 - Jun. 17
Stay at this hotel in Cairo. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Fort Defiance State Park and Ballard Wildlife Management Area are located nearby.
Pet-friendly
Pool
Super 8 by Wyndham Charleston MO

Super 8 by Wyndham Charleston MO

2 out of 5
310 S Story St, Charleston, MO
Free cancellation
Reserve now, pay when you stay
The price is CA $92 per night
CA $92
per night
May 19 - May 20
Stay at this motel in Charleston. Enjoy free breakfast, free WiFi, and free parking.
Quality Inn Charleston I-57

Quality Inn Charleston I-57

2.5 out of 5
102 Drake St, I-57 Exit 10, Charleston, MO
Free cancellation
Reserve now, pay when you stay
The price is CA $93 per night
CA $93
per night
Jun. 2 - Jun. 3
Book a stay at this business-friendly hotel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our reviews.
Pet-friendly
Breakfast included
Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre

The price is CA $204 per night
CA $204
per night
May 19 - May 20
Stay at this cabin in Dongola. Enjoy free WiFi, a garden, and patios. Popular attractions Dongola Lake and Dongola Public Library are located nearby.
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Get rates
Stay at this vacation home in Ballard County. Enjoy free breakfast, free WiFi, and a garden. Our guests praise the clean rooms in our reviews.
Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake

The price is CA $157 per night
CA $157
per night
May 19 - May 20
Stay at this cabin in Alexander County. Enjoy patios, an in-room coffeemaker, and air conditioning.
Outdoor space
Air conditioning
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Image for Fort Defiance State Park

Fort Defiance State Park

Explore the great outdoors at Fort Defiance State Park, a lovely green space in Cairo. Stroll along the riverfront or experience the area's entertainment venues.

Fort Defiance State Park

Cairo Vacations

Unintentionally stumbling upon a new place is exactly what traveling is all about, But of course, it certainly never hurts to learn a bit about the destination before you race off. We'll help you discover some basic facts about Cairo.

If you take a trip 25 miles (40 kilometers) northeast of Sikeston, or 30 miles (48 kilometers) southeast of Cape Girardeau, you'll be in Cairo.

At the most recent count, the population of this part of Southwest Illinois was 3,000.

Places to visit in Cairo

Try to imagine the troops who once stood watch at Fort Defiance. The brutality of past wars can still be found on its thick walls. Want more options? Marvel at ornate tombstones and poetic epitaphs at Mound City National Cemetery. But that's not all there is. Immerse yourself in nature at Ballard Wildlife Management Area and admire the great work they're doing to conserve native habitats and their wildlife.

Where do you fly into for Cairo?

While you're arranging your Cairo escape, bear in mind that the closest major terminal, Cape Girardeau Municipal Airport (CGI), is approximately 25 miles (40 kilometers) to the northwest of the downtown area. Book your flight, pack your suitcase and prepare for some exciting adventures!

Frequently asked questions

How much are vacation packages to Cairo?
Treat yourself to a fulfilling travel experience in Cairo with a vacation package starting from as low as . Locking in your hotels, tours and flights through Travelocity is a piece of cake. What’s more, our deals will leave you with more money in your pocket for fun times.
How long should my Cairo vacation be?
Most travelers secure a hotel for 3 nights in Cairo. But that doesn’t necessarily mean you have to follow their lead. How long you spend here depends on what you want to do on your vacation. If you intend to discover every nook and cranny of this awesome place, treat yourself to another couple of nights (or even an extra week!).
Where can I get the best vacation package deals for Cairo?
Travelocity will be able to help you lock in a terrific Cairo package deal. With as many as 400 airlines and 665,000 properties across the globe, you’re bound to find the perfect combination.
Why should I purchase my Cairo vacation bundle via Travelocity?
By booking your flights, hotel, activities and car rental all in one place, you’ll save both time and money. We offer an expert team of customer service specialists available 24/7, and you’ll know that you’re always getting the lowest price possible with our Price Match Guarantee. So, what are you waiting for? Book the getaway of your dreams today and get packing!
Can I save on my Cairo car rental if I combine it with my hotel or flight?
With a Cairo vacation package, you can bundle your car, flight and hotel bookings and save tons. If you can’t wait to see the best of this wonderful part of the world, why not check out Gateway Arch? This popular sight is 200 kilometersfrom Cairo. With a rental car, you’ll be there in a jiffy.
What is the best time of year to go to Cairo?
If you love to wander wisely, is an excellent time to do it. That’s when hotel rates are at their most affordable. In contrast, prices skyrocket in . are the most popular months to visit Cairo, so brace for long queues at major tourist sites. Prefer to avoid peak season? You’ll find smaller crowds during .
Which airport is best for Cairo?
There’s a good chance you’ll be landing at Marion, IL (MWA-Williamson County Regional), which is 80 kilometersnorth of downtown Cairo. Paducah, KY (PAH-Barkley Regional) (40 kilometersaway from central Cairo) and Cape Girardeau, MO (CGI-Cape Girardeau Municipal) (40 kilometersaway from central Cairo) are your other choices.
What is there to do in Cairo?
Fort Defiance should be at the top of your must-see list. After you’ve crossed off this leading attraction, wander through the streets of Cairo and get a feel for what makes this vibrant destination tick.
Where should I stay when visiting Cairo?
Many visitors opt to hit the hay at the Quality Inn Cairo I-57. It’s a great base for your Cairo getaway.
Can I go on vacation to Cairo at this time?
Discover all the info you should know about travel restrictions and quarantine policies before you head for Cairo. Our Covid-19 Travel Advisor is full of useful advice to help make your vacation as hassle-free as possible.