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Top Cairo hotels deals

Quality Inn Cairo I-57

Quality Inn Cairo I-57

2.5 out of 5
13201 Kessler Road, Cairo, IL
Free cancellation
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Stay at this hotel in Cairo. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Fort Defiance State Park and Ballard Wildlife Management Area are located nearby.
Breakfast included
Pet-friendly
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2 out of 5
310 S Story St, Charleston, MO
Free cancellation
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Stay at this motel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews.
Breakfast included
Pet-friendly
Quality Inn Charleston - Sikeston

Quality Inn Charleston - Sikeston

2.5 out of 5
102 Drake St, I-57 Exit 10, Charleston, MO
Free cancellation
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Book a stay at this business-friendly hotel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our reviews.
Breakfast included
Pet-friendly
Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake

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Stay at this cabin in Alexander County. Enjoy patios, an in-room coffeemaker, and air conditioning.
Air conditioning
Lake view
Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake

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Stay at this cabin in Alexander County. Enjoy an in-room coffeemaker and air conditioning.
Kitchen
Pet-friendly
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

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Stay at this vacation home in Kevil. Enjoy free breakfast, free WiFi, and a garden.
Breakfast included
Kitchen
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Fort Defiance State Park

You can take time to visit Fort Defiance State Park during your travels to Cairo. Stroll along the riverfront or visit the churches while you're in the area.

Fort Defiance State Park

Cairo Vacations

Unintentionally stumbling upon a new place is exactly what traveling is all about, But of course, it certainly never hurts to learn a bit about the destination before you race off. We'll help you discover some basic facts about Cairo.

If you take a trip 25 miles (40 kilometers) northeast of Sikeston, or 30 miles (48 kilometers) southeast of Cape Girardeau, you'll be in Cairo.

At the most recent count, the population of this part of Southwest Illinois was 3,000.

Places to visit in Cairo

Try to imagine the troops who once stood watch at Fort Defiance. The brutality of past wars can still be found on its thick walls. Want more options? Marvel at ornate tombstones and poetic epitaphs at Mound City National Cemetery. But that's not all there is. Immerse yourself in nature at Ballard Wildlife Management Area and admire the great work they're doing to conserve native habitats and their wildlife.

Where do you fly into for Cairo?

While you're arranging your Cairo escape, bear in mind that the closest major terminal, Cape Girardeau Municipal Airport (CGI), is approximately 25 miles (40 kilometers) to the northwest of the downtown area. Book your flight, pack your suitcase and prepare for some exciting adventures!

Frequently asked questions

How much are vacation packages to Cairo?
You’ll be pleasantly surprised — you can find yourself in Cairo for just . Allow Travelocity to save you time and money with our awesome vacation package deals. With hotels, flights and tours all in one place, what are you waiting for?
Where can I get the best vacation package deals for Cairo?
With around 400 partner airlines and 1,000,000 hotels across the world, you can’t beat Travelocity. Scroll through our impressive range and create the perfect package deal to Cairo. Doesn’t it feel amazing when organizing a trip is that easy?
Why should I book my Cairo vacation package via Travelocity?
Nothing tops the satisfaction of knowing you’ve bagged the best price around — that’s our Price Match Guarantee. Add to that our fantastic range of destinations and 24/7 team of customer service professionals and you’ve got the formula for a stress-free vacation.
Can I save on my Cairo car rental if I book it with hotels and flights?
With a Cairo vacation package, you can bundle your car, flight and hotel bookings and save some serious money. When you’re ready to explore the best of this awesome city, why not make a beeline for Anheuser-Busch Brewery? This popular attraction is 193 kilometers from Cairo. With your own rental car, you’ll be there in the blink of an eye.
Which airport is best for Cairo?
Williamson County Regional Airport (MWA) is 80 kilometers from downtown and is the beginning point for many memorable experiences. Alternatively, Cape Girardeau Municipal Airport (CGI) is 40 kilometers away from central Cairo and Barkley Regional Airport (PAH) is 40 kilometers away from central Cairo.
What is there to do in Cairo?
Click away at the excellent photo opportunities at Fort Defiance State Park, one of the most popular attractions in Cairo. There’s a lot more to discover around this exciting city, so make sure you have enough time to visit some of its off-the-beaten-path gems.
Where should I stay when visiting Cairo?
The Quality Inn Cairo I-57 is popular with many visitors. Book soon to avoid missing out.

Photos of local treasures

Browse Cairo vacation photos for more inspiration