
Book Cheap American Airlines flight from Detroit (DTW) to San Diego (SAN) from CA $388
Find The Best Day to Book a Cheap American Airlines Flights From Detroit to San Diego
Cheapest American Airlines Flights from Detroit (DTW) to San Diego (SAN)
The cheapest flights to San Diego Intl. found within the past 7 days were CA $800 round trip and CA $388 one way. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Grab a great American Airlines flight from DTW to SAN
To find a great deal on American Airlines flights with Travelocity, simply enter your origin and destination airports, pick your travel dates, and hit search. From here, you can sort by price, flight duration, and arrival/departure time. You can also filter to find nonstop flights.
Flying American Airlines Detroit to San Diego gives you fights to choose from. With that direct flight time of , you’ll be touching down before you know it.
Find cheap flights with American Airlines between Detroit and San Diego
American Airlines has a range of great fares on stacks of flights, and to find the most affordable for you, there are a few tricks you can try. Booking in advance, for example, is a great way to grab a fantastic deal. Also, choose the cheapest month, if you can. One-way flights from Detroit to San Diego with American Airlines are May.
The more flexible you are, the more affordable flights you’re likely to find. Consider one-way flights and connecting flights, as well as standard roundtrip and direct options. Even if you’re flying today, cheap last-minute flights are easy to find by entering your travel dates and hitting search.
Reasons to book your American Airlines flights with Travelocity
Travelocity makes it easy to book a seat, anywhere in the world. The vast inventory, fast search, and advanced filters put some of the best deals on the planet in one place. Whether you’re traveling on business, with friends, family, or on your own, take your pick from some fantastic options. And with free cancellation and pay later options, you can travel more and worry less.
Airport code | Country | Airport name | Number of flights |
|---|---|---|---|
| DFW | USA | Dallas-Fort Worth Intl. | 599 |
| CLT | USA | Charlotte-Douglas Intl. | 536 |
| ORD | USA | O'Hare Intl. | 317 |
| PHL | USA | Philadelphia Intl. | 247 |
| MIA | USA | Miami Intl. | 193 |
| DCA | USA | Ronald Reagan Washington National | 152 |
| PHX | USA | Sky Harbor Intl. | 141 |
| LAX | USA | Los Angeles Intl. | 81 |
| LGA | USA | LaGuardia | 72 |
| BOS | USA | Logan Intl. | 57 |
Travelers ❤️ these 🏨 after their flight to San Diego

Sheraton San Diego Resort
WATCH OUT FOR THE RESORT FEE! Wow... I booked this hotel on Expedia and when I checked out... surprise... surpise... a $44 per night "resort fee" was quietly charged to my credit card. Nobody explained this at check-in. The hotel is very reasonably priced, but I didn't like getting hit with the resort ...
Reviewed on Mar 18, 2026

Wyndham San Diego Bayside
Room was filthy. Carpet was wet. Shower door didn’t work. The gym is very run down, the ac was dripping and the floor all wet. The whole property has a very particular smell. Poorly maintained overall
Reviewed on Mar 19, 2026

The DEXTRO Little Italy, BW Premier Collection
Everything was amazing, I walked everywhere
Reviewed on Mar 19, 2026
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