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Featured Palermo 4 Star hotels

Hotel Politeama

Hotel Politeama

4 out of 5
Piazza Ruggiero Settimo,15 Palermo PA
The price is CA $251 per night from Apr 13 to Apr 14
CA $251
CA $290 total
Apr 13 - Apr 14
includes taxes & fees
Book a stay at this business-friendly hotel in Palermo. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (506 reviews)
Excellent breakfast. Location super. Very helpful and accommodating staff. A definite find ! Thanks to Filippo on the way in and Alessio during our stay.

Reviewed on Mar 28, 2026

Opens in a new windowHotel Politeama
NH Palermo

NH Palermo

4 out of 5
Foro Italico Palermo PA
Fully refundableReserve now, pay when you stay
The price is CA $154 per night from Apr 6 to Apr 7
CA $154
CA $183 total
Apr 6 - Apr 7
includes taxes & fees
Stay at this hotel in Palermo. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions ...
8.2/10 Very Good! (1,000 reviews)
Great location with amazing views of the sea and coastline and very close to the old town, botanic gardens and Villa Guilia. Our room was on 3rd floor with balcony. Large room with a huge bed, moden decor and a powerful shower. Breakfast was plentiful and staff were attentive. Highly ...

Reviewed on Mar 26, 2026

Opens in a new windowNH Palermo
Casena Dei Colli, Sure Hotel Collection by Best Western

Casena Dei Colli, Sure Hotel Collection by Best Western

4 out of 5
Via Villa Rosato 20-22 Palermo PA
Fully refundableReserve now, pay when you stay
The price is CA $93 per night from Apr 6 to Apr 7
CA $93
CA $116 total
Apr 6 - Apr 7
includes taxes & fees
Book a stay at this business-friendly hotel in Palermo. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Mondello Beach and Palermo ...
8.2/10 Very Good! (913 reviews)
I stayed one night in Palermo, and since it’s almost impossible to find a hotel with parking in the city center, this hotel was a great find. It offers free parking, which is a huge advantage. The rooms are large and comfortable, the price is very affordable, and the reception staff is warm and friendly. ...

Reviewed on Jan 23, 2026

Opens in a new windowCasena Dei Colli, Sure Hotel Collection by Best Western
Mercure Hotel Palermo Centro

Mercure Hotel Palermo Centro

4 out of 5
Via Stabile Mariano 112 Palermo PA
Fully refundableReserve now, pay when you stay
The price is CA $187 per night from Apr 2 to Apr 3
CA $187
CA $220 total
Apr 2 - Apr 3
includes taxes & fees
Book a stay at this business-friendly hotel in Palermo. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,001 reviews)
Near shopping and restaurants. Bus stop nearby to take you to the historical town. Hotel caters to large tour groups, so lots of guests at breakfast and check in. Breakfast was ok.

Reviewed on Mar 18, 2026

Opens in a new windowMercure Hotel Palermo Centro
President Hotel Palermo

President Hotel Palermo

4 out of 5
Via Francesco Crispi 230 Palermo PA
Fully refundableReserve now, pay when you stay
The price is CA $107 per night from Apr 6 to Apr 7
CA $107
CA $165 total
Apr 6 - Apr 7
includes taxes & fees
Book a stay at this business-friendly hotel in Palermo. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Popular attractions Palermo Harbour and ...
Opens in a new windowPresident Hotel Palermo
NH Collection Palermo Palazzo Sitano

NH Collection Palermo Palazzo Sitano

4 out of 5
Via Vittorio Emanuele, 114 Palermo PA
Fully refundableReserve now, pay when you stay
The price is CA $384 per night from Apr 27 to Apr 28
CA $384
CA $437 total
Apr 27 - Apr 28
includes taxes & fees
Book a stay at this business-friendly hotel in Palermo. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions Via Roma and Quattro Canti ...
Opens in a new windowNH Collection Palermo Palazzo Sitano
Palazzo Natoli Boutique Hotel

Palazzo Natoli Boutique Hotel

4 out of 5
Via Santissimo Salvatore 6 Palermo PA
The price is CA $351 per night from Apr 2 to Apr 3
CA $351
CA $400 total
Apr 2 - Apr 3
includes taxes & fees
Book a stay at this business-friendly hotel in Palermo. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful staff ...
9.8/10 Exceptional! (462 reviews)
This was an excellent hotel in every way. Rome was spacious, clean, beautiful. Staff were courteous and helpful. Breakfast amazing! Great location!

Reviewed on Mar 11, 2026

Opens in a new windowPalazzo Natoli Boutique Hotel
Quintocanto Hotel and Spa

Quintocanto Hotel and Spa

4 out of 5
Corso Vittorio Emanuele, 310 Palermo PA
Fully refundableReserve now, pay when you stay
The price is CA $170 per night from Apr 13 to Apr 14
CA $170
CA $201 total
Apr 13 - Apr 14
includes taxes & fees
Book a stay at this spa hotel in Palermo. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. Popular ...
8.4/10 Very Good! (515 reviews)
Great location. Very comfortable.

Reviewed on Mar 15, 2026

Opens in a new windowQuintocanto Hotel and Spa
Eurostars Centrale Palace

Eurostars Centrale Palace

4 out of 5
Via Vittorio Emanuele, 327 Palermo PA
Fully refundableReserve now, pay when you stay
The price is CA $213 per night from Apr 6 to Apr 7
CA $213
CA $249 total
Apr 6 - Apr 7
includes taxes & fees
Book a stay at this luxury hotel in Palermo. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
8.4/10 Very Good! (1,001 reviews)
Clean room, comfortable bed, great shower and location

Reviewed on Feb 23, 2026

Opens in a new windowEurostars Centrale Palace
Hotel Plaza Opera

Hotel Plaza Opera

4 out of 5
Via Gallo Nicolo' 2 Palermo PA
Fully refundableReserve now, pay when you stay
The price is CA $255 per night from Apr 7 to Apr 8
CA $255
CA $294 total
Apr 7 - Apr 8
includes taxes & fees
Book a stay at this spa hotel in Palermo. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
8.6/10 Excellent! (621 reviews)
Great location. Staff was very friendly. Hotel was amazing

Reviewed on Mar 20, 2026

Opens in a new windowHotel Plaza Opera
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4 Star Hotels Palermo

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Palermo 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Palermo will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Palermo, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

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