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Featured Panama City 5 Star hotels

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $187 per night from Mar 3 to Mar 4
CA $187
CA $206 total
Mar 3 - Mar 4
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (4,938 reviews)
Hotel is great. Great breakfast. Amazing

Reviewed on Feb 9, 2026

Opens in a new windowHotel Riu Plaza Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $300 per night from Mar 7 to Mar 8
CA $300
CA $330 total
Mar 7 - Mar 8
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (1,004 reviews)
Clean, very polite and friendly staff. I loved the country.

Reviewed on Feb 10, 2026

Opens in a new windowWaldorf Astoria Panama
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
The price is CA $249 per night from Mar 7 to Mar 8
CA $249
CA $274 total
Mar 7 - Mar 8
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy 2 restaurants, 3 hot tubs, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,006 reviews)
The room was very clean, the staff and amenities were excellent. My only complaint is the thin walls and windows. I heard everything going on in the next room, and all the cars blowing their horns outside. I was on the 17th floor and it was like I was outside.

Reviewed on Feb 8, 2026

Opens in a new windowW Panama
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $407 per night from Mar 9 to Mar 10
CA $407
CA $448 total
Mar 9 - Mar 10
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,000 reviews)
Beautiful hotel, great service. Breakfast buffet is amazing.

Reviewed on Jan 29, 2026

Opens in a new windowJW Marriott Panama
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Calle Primera Oeste, San Felipe Panama City Panama
The price is CA $515 per night from Feb 23 to Feb 24
CA $515
CA $567 total
Feb 23 - Feb 24
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property ...
9.8/10 Exceptional! (588 reviews)
The hotel was LOVELY and the staff so kind and helpful. Highly, highly recommend! Also-- I highly recommend a higher floor! While they say the 1st is the quietest, the higher floors have beautiful balconies and no problem with noise!

Reviewed on Feb 8, 2026

Opens in a new windowSofitel Legend Casco Viejo, Panama City
Hilton Panama

Hilton Panama

5 out of 5
Balboa Ave. and Aquilino De La Guardia Panama City
Fully refundableReserve now, pay when you stay
The price is CA $299 per night from Mar 8 to Mar 9
CA $299
CA $329 total
Mar 8 - Mar 9
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the helpful staff in our ...
8.8/10 Excellent! (1,001 reviews)
The room was clean. Housekeeping excellent . Very spacious balcony overlooking the ocean. Beautiful pool and bar overlooking the ocean. Room service very good prices reasonable

Reviewed on Feb 11, 2026

Opens in a new windowHilton Panama
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5 out of 5
Km 6 Road to Veracruz Veracruz Panama
Fully refundableReserve now, pay when you stay
The price is CA $322 per night from Mar 9 to Mar 10
CA $322
CA $355 total
Mar 9 - Mar 10
includes taxes & fees
Book a stay at this luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8/10 Very Good! (1,012 reviews)
Clean rooms

Reviewed on Feb 2, 2026

Opens in a new windowThe Westin Playa Bonita Panama
Renaissance Panama City Hotel

Renaissance Panama City Hotel

5 out of 5
Via España & Ricardo Arias Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $172 per night from Feb 20 to Feb 21
CA $172
CA $190 total
Feb 20 - Feb 21
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a casino. Popular attractions Albrook Shopping Mall and Avenida Balboa ...
8.8/10 Excellent! (151 reviews)
Comfortable

Reviewed on Feb 7, 2026

Opens in a new windowRenaissance Panama City Hotel
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
Avenida Aquilino de La Guardia Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $251 per night from Mar 16 to Mar 17
CA $251
CA $276 total
Mar 16 - Mar 17
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,007 reviews)
Everything was perfect at this hotel. Honestly the best hotel I've had the pleasure staying at while in Panama City. Will definitely return

Reviewed on Feb 9, 2026

Opens in a new windowBristol Panama, a Registry Collection Hotel
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
Santa Maria Boulevard Panama City
The price is CA $367 per night from Mar 7 to Mar 8
CA $367
CA $403 total
Mar 7 - Mar 8
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (662 reviews)
It was my first time staying at the hotel and it was wonderful!! The check in was great and the staff I ran into the two days I stayed were great and very kind

Reviewed on Feb 9, 2026

Opens in a new windowThe Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
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Five Star Hotels in Panama City

Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Panama City hotel reviews by fellow wanderers