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Featured Panama City 5 Star hotels

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $166 per night from Dec 8 to Dec 9
CA $166
CA $183 total
Dec 8 - Dec 9
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (4,491 reviews)
Staff very friendly and helpful

Reviewed on Nov 11, 2025

Opens in a new windowHotel Riu Plaza Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $240 per night from Dec 1 to Dec 2
CA $240
CA $264 total
Dec 1 - Dec 2
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (1,002 reviews)
Very beautiful room was spotless, and staff was very good with customer service

Reviewed on Nov 7, 2025

Opens in a new windowWaldorf Astoria Panama
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
The price is CA $246 per night from Dec 7 to Dec 8
CA $246
CA $270 total
Dec 7 - Dec 8
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy 2 restaurants, 3 hot tubs, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,007 reviews)
Clean room, great views, great staff!

Reviewed on Nov 10, 2025

Opens in a new windowW Panama
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $277 per night from Dec 7 to Dec 8
CA $277
CA $304 total
Dec 7 - Dec 8
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,002 reviews)
The bath tub was not stable and water was leaked out. Excellent view though

Reviewed on Nov 14, 2025

Opens in a new windowJW Marriott Panama
Renaissance Panama City Hotel

Renaissance Panama City Hotel

5 out of 5
Via España & Ricardo Arias Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is CA $163 per night from Nov 23 to Nov 24
CA $163
CA $179 total
Nov 23 - Nov 24
includes taxes & fees
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a casino. Popular attractions Albrook Shopping Mall and Via Espana ...
9/10 Wonderful! (80 reviews)
Great location and amazing staff

Reviewed on Nov 10, 2025

Opens in a new windowRenaissance Panama City Hotel
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
Avenida Aquilino de La Guardia Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $223 per night from Dec 6 to Dec 7
CA $223
CA $245 total
Dec 6 - Dec 7
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,000 reviews)
Everything was good. We were satisfied

Reviewed on Nov 8, 2025

Opens in a new windowBristol Panama, a Registry Collection Hotel
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Calle Primera Oeste, San Felipe Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $410 per night from Dec 15 to Dec 16
CA $410
CA $451 total
Dec 15 - Dec 16
includes taxes & fees
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property ...
9.8/10 Exceptional! (529 reviews)
The staff was fantastic and catered to our every need. The pool was and we received fantastic service there despite it being busy.

Reviewed on Nov 9, 2025

Opens in a new windowSofitel Legend Casco Viejo, Panama City
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5 out of 5
Km 6 Road to Veracruz Veracruz Panama
Fully refundableReserve now, pay when you stay
The price is CA $233 per night from Dec 10 to Dec 11
CA $233
CA $257 total
Dec 10 - Dec 11
includes taxes & fees
Book a stay at this luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8/10 Very Good! (1,002 reviews)
The lobby smells amazing!

Reviewed on Nov 8, 2025

Opens in a new windowThe Westin Playa Bonita Panama
Hilton Panama

Hilton Panama

5 out of 5
Balboa Ave. and Aquilino De La Guardia, Panama City
Fully refundableReserve now, pay when you stay
The price is CA $250 per night from Dec 7 to Dec 8
CA $250
CA $275 total
Dec 7 - Dec 8
includes taxes & fees
Stay at this 5-star luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the helpful staff in our ...
8.8/10 Excellent! (1,000 reviews)
This hotel is perfection - in every respect. The best location, best amenities, awesome food, great entertainment, excellent service.

Reviewed on Oct 16, 2025

Opens in a new windowHilton Panama
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
Santa Maria Boulevard, Panama City
Fully refundableReserve now, pay when you stay
The price is CA $304 per night from Nov 30 to Dec 1
CA $304
CA $334 total
Nov 30 - Dec 1
includes taxes & fees
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (624 reviews)
This is a quality hotel with quality service. Recommend it

Reviewed on Oct 30, 2025

Opens in a new windowThe Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
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Five Star Hotels in Panama City

Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Panama City hotel reviews by fellow wanderers