Find and compare 5 Star hotels in Panama City

Name: The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Price range: CA $367
Rating: 9.6

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Featured Panama City 5 Star hotels

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama

Fully refundableReserve now, pay when you stay

CA $187

CA $206 total

Mar 3 - Mar 4

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...

9/10 Wonderful! (4,938 reviews)

Hotel is great. Great breakfast. Amazing

Reviewed on Feb 9, 2026

Waldorf Astoria Panama

47th St. & Uruguay Street Panama City Panama

Fully refundableReserve now, pay when you stay

CA $300

CA $330 total

Mar 7 - Mar 8

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...

8.8/10 Excellent! (1,004 reviews)

Clean, very polite and friendly staff. I loved the country.

Reviewed on Feb 10, 2026

W Panama

Calle Aquilino de la Guardia & Calle 50 Panama City

Fully refundableReserve now, pay when you stay

CA $249

CA $274 total

Mar 7 - Mar 8

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy 2 restaurants, 3 hot tubs, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular ...

8.8/10 Excellent! (1,006 reviews)

The room was very clean, the staff and amenities were excellent. My only complaint is the thin walls and windows. I heard everything going on in the next room, and all the cars blowing their horns outside. I was on the 17th floor and it was like I was outside.

Reviewed on Feb 8, 2026

JW Marriott Panama

Calle Punta Colon, Punta Pacifica Panama City Panama

Fully refundableReserve now, pay when you stay

CA $407

CA $448 total

Mar 9 - Mar 10

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...

8.8/10 Excellent! (1,000 reviews)

Beautiful hotel, great service. Breakfast buffet is amazing.

Reviewed on Jan 29, 2026

Sofitel Legend Casco Viejo, Panama City

Calle Primera Oeste, San Felipe Panama City Panama

CA $515

CA $567 total

Feb 23 - Feb 24

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property ...

9.8/10 Exceptional! (588 reviews)

The hotel was LOVELY and the staff so kind and helpful. Highly, highly recommend! Also-- I highly recommend a higher floor! While they say the 1st is the quietest, the higher floors have beautiful balconies and no problem with noise!

Reviewed on Feb 8, 2026

Hilton Panama

Balboa Ave. and Aquilino De La Guardia Panama City

Fully refundableReserve now, pay when you stay

CA $299

CA $329 total

Mar 8 - Mar 9

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the helpful staff in our ...

8.8/10 Excellent! (1,001 reviews)

The room was clean. Housekeeping excellent . Very spacious balcony overlooking the ocean. Beautiful pool and bar overlooking the ocean. Room service very good prices reasonable

Reviewed on Feb 11, 2026

The Westin Playa Bonita Panama

Km 6 Road to Veracruz Veracruz Panama

Fully refundableReserve now, pay when you stay

CA $322

CA $355 total

Mar 9 - Mar 10

includes taxes & fees

Book a stay at this luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...

8/10 Very Good! (1,012 reviews)

Clean rooms

Reviewed on Feb 2, 2026

Renaissance Panama City Hotel

Via España & Ricardo Arias Street Panama City Panama

Fully refundableReserve now, pay when you stay

CA $172

CA $190 total

Feb 20 - Feb 21

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a casino. Popular attractions Albrook Shopping Mall and Avenida Balboa ...

8.8/10 Excellent! (151 reviews)

Comfortable

Reviewed on Feb 7, 2026

Bristol Panama, a Registry Collection Hotel

Avenida Aquilino de La Guardia Panama City Panama

Fully refundableReserve now, pay when you stay

CA $251

CA $276 total

Mar 16 - Mar 17

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...

9.2/10 Wonderful! (1,007 reviews)

Everything was perfect at this hotel. Honestly the best hotel I've had the pleasure staying at while in Panama City. Will definitely return

Reviewed on Feb 9, 2026

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Santa Maria Boulevard Panama City

CA $367

CA $403 total

Mar 7 - Mar 8

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...

9.6/10 Exceptional! (662 reviews)

It was my first time staying at the hotel and it was wonderful!! The check in was great and the staff I ran into the two days I stayed were great and very kind

Reviewed on Feb 9, 2026

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Five Star Hotels in Panama City

Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.