Find and compare 5 Star hotels in Panama City

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Featured Panama City 5 Star hotels

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $189 per night from Jun 15 to Jun 16
CA $189
CA $208 total
Jun 15 - Jun 16
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (5,460 reviews)
"Very good property that has a good breakfast buffet. Staff was very nice"

Reviewed on May 22, 2026

Opens in a new windowHotel Riu Plaza Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $350 per night from Jun 19 to Jun 20
CA $350
CA $385 total
Jun 19 - Jun 20
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (1,000 reviews)
"Excelentes instalaciones y el personal es increíble de lo amable y con ganas de satisfacer tus deseos"

Reviewed on May 18, 2026

Opens in a new windowWaldorf Astoria Panama
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Calle Primera Oeste, San Felipe Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $415 per night from Jun 5 to Jun 6
CA $415
CA $457 total
Jun 5 - Jun 6
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property ...
9.8/10 Exceptional! (654 reviews)
"Easily one the best hotel stays ever. Great property. Great food. Excellent service."

Reviewed on May 14, 2026

Opens in a new windowSofitel Legend Casco Viejo, Panama City
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $352 per night from Jun 19 to Jun 20
CA $352
CA $387 total
Jun 19 - Jun 20
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
9/10 Wonderful! (1,002 reviews)
"The entire staff were amazing, front desk, cleaning personnel, front door, restaurant staff, everyone in the entire building were nice, professional and informative. I am definitely recommending this hotel for anyone who has the slightest interest."

Reviewed on May 22, 2026

Opens in a new windowJW Marriott Panama
Hyatt Regency Panama City

Hyatt Regency Panama City

5 out of 5
Calle 52 and Ricardo Arias Panama City Panamá Province
Fully refundableReserve now, pay when you stay
The price is CA $240 per night from Jun 20 to Jun 21
CA $240
CA $264 total
Jun 20 - Jun 21
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and 2 restaurants. Popular attractions Albrook Shopping Mall and Avenida ...
9.6/10 Exceptional! (311 reviews)
"Great price on a suite!"

Reviewed on May 20, 2026

Opens in a new windowHyatt Regency Panama City
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
The price is CA $343 per night from May 24 to May 25
CA $343
CA $377 total
May 24 - May 25
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy 2 restaurants, 3 hot tubs, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular ...
9/10 Wonderful! (1,003 reviews)
"We booked the Supreme Room and it was amazing! It had a great view and was very spacious. Upon arrival, the staff was so nice and helpful. They provided us with suggestions on where to go to eat, party and sightsee. They were always available if we had questions too. The location was close to everything ..."

Reviewed on May 4, 2026

Opens in a new windowW Panama
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5 out of 5
Km 6 Road to Veracruz Veracruz Panama
Fully refundableReserve now, pay when you stay
The price is CA $265 per night from Jun 7 to Jun 8
CA $265
CA $291 total
Jun 7 - Jun 8
includes taxes & fees
Book a stay at this luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8/10 Very Good! (1,001 reviews)
"Friendly staff,great accomadations . Very relaxing. I will go back."

Reviewed on May 7, 2026

Opens in a new windowThe Westin Playa Bonita Panama
Hilton Panama

Hilton Panama

5 out of 5
Balboa Ave. and Aquilino De La Guardia Panama City
Fully refundableReserve now, pay when you stay
The price is CA $314 per night from Jun 7 to Jun 8
CA $314
CA $346 total
Jun 7 - Jun 8
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the helpful staff in our ...
9/10 Wonderful! (1,001 reviews)
"Very helpful and responsive staff. Quality across the board"

Reviewed on May 20, 2026

Opens in a new windowHilton Panama
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
Santa Maria Boulevard Panama City
Fully refundableReserve now, pay when you stay
The price is CA $319 per night from Jun 5 to Jun 6
CA $319
CA $350 total
Jun 5 - Jun 6
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (695 reviews)
"Perfect"

Reviewed on May 8, 2026

Opens in a new windowThe Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Renaissance Panama City Hotel

Renaissance Panama City Hotel

5 out of 5
Via España & Ricardo Arias Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $175 per night from May 30 to May 31
CA $175
CA $192 total
May 30 - May 31
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a casino. Popular attractions Albrook Shopping Mall and Avenida Balboa ...
8.8/10 Excellent! (216 reviews)
"Breakfast was very good, staff are very helpful and friendly"

Reviewed on May 11, 2026

Opens in a new windowRenaissance Panama City Hotel
Don't see what you're looking for?
See all available properties in Panama City
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Five Star Hotels in Panama City

Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Panama City hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity