Find and compare 5 Star hotels in Panama City

Name: The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Price range: CA $287
Rating: 9.6

Wander Wisely with exceptional service, 24/7 support

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Featured Panama City 5 Star hotels

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama

Fully refundableReserve now, pay when you stay

CA $168

CA $184 total

Jan 18 - Jan 19

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...

9/10 Wonderful! (4,732 reviews)

The staff were very friendly. The room was cleaned on time. They even gave me a little gift for my birthday, which I was surprised and impressed!

Reviewed on Dec 29, 2025

Waldorf Astoria Panama

47th St. & Uruguay Street Panama City Panama

Fully refundableReserve now, pay when you stay

CA $302

CA $332 total

Jan 10 - Jan 11

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...

8.8/10 Excellent! (1,002 reviews)

Lovely stay and lovely price. Luxury in Panama

Reviewed on Dec 28, 2025

W Panama

Calle Aquilino de la Guardia & Calle 50 Panama City

Fully refundableReserve now, pay when you stay

CA $256

CA $281 total

Jan 30 - Jan 31

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy 2 restaurants, 3 hot tubs, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular ...

8.8/10 Excellent! (1,009 reviews)

The room was very spacious and modern, surpassed my expectations!

Reviewed on Dec 29, 2025

JW Marriott Panama

Calle Punta Colon, Punta Pacifica Panama City Panama

Fully refundableReserve now, pay when you stay

CA $396

CA $435 total

Jan 4 - Jan 5

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...

8.8/10 Excellent! (1,001 reviews)

Just wonderful hotel

Reviewed on Dec 16, 2025

Sofitel Legend Casco Viejo, Panama City

Calle Primera Oeste, San Felipe Panama City Panama

Fully refundableReserve now, pay when you stay

CA $437

CA $481 total

Feb 1 - Feb 2

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property ...

9.8/10 Exceptional! (568 reviews)

The decor was beautiful, very clean and pleasant fragrance inside. Food was great too. The very best thing was the helpful, friendly and attentive staff. Everyone, front desk, butlers, concierge, wait staff, room staff, doormen and drivers, all made us feel well taken care of and treated us like ...

Reviewed on Dec 26, 2025

Hilton Panama

Balboa Ave. and Aquilino De La Guardia Panama City

Fully refundableReserve now, pay when you stay

CA $276

CA $304 total

Jan 3 - Jan 4

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the helpful staff in our ...

8.8/10 Excellent! (1,002 reviews)

The restaurant at the pool, Caio Lagazzi, was amazing. The Hilton breakfast was top notch, except that they were a little slow bringing drinks (but to be fair it was Christmas day and they may have been understaffed).

Reviewed on Dec 27, 2025

The Westin Playa Bonita Panama

Km 6 Road to Veracruz Veracruz Panama

Fully refundableReserve now, pay when you stay

CA $336

CA $370 total

Jan 10 - Jan 11

includes taxes & fees

Book a stay at this luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...

8/10 Very Good! (1,000 reviews)

The view was fantastic! The pool was very relaxing and the food was great.

Reviewed on Dec 24, 2025

Renaissance Panama City Hotel

Via España & Ricardo Arias Street Panama City Panama

Fully refundableReserve now, pay when you stay

CA $150

CA $165 total

Jan 5 - Jan 6

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a casino. Popular attractions Albrook Shopping Mall and Avenida Balboa ...

8.8/10 Excellent! (96 reviews)

The staff is always amazing. The breakfast is great and the location is perfect.

Reviewed on Nov 24, 2025

Bristol Panama, a Registry Collection Hotel

Avenida Aquilino de La Guardia Panama City Panama

Fully refundableReserve now, pay when you stay

CA $265

CA $292 total

Jan 31 - Feb 1

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...

9.2/10 Wonderful! (1,003 reviews)

Breakfast menu is excellent the food is exceptional, the staff very friendly. All part of a wonderful experience.

Reviewed on Dec 28, 2025

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Santa Maria Boulevard Panama City

Fully refundableReserve now, pay when you stay

CA $287

CA $315 total

Jan 4 - Jan 5

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...

9.6/10 Exceptional! (644 reviews)

this is the best place to stay near the airport. great rooms, fantastic staff. The best breakfast ever! this is not my first time at Santa Maria and definitely not the last!!!

Reviewed on Dec 11, 2025

Don't see what you're looking for?

See all available properties in Panama City

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Five Star Hotels in Panama City

Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.