Cheap Flight Deals to Sikeston MO from CA $253

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How to find cheap flights to Sikeston?

The cheapest prices found with in the last 7 days for return flights were CA $206 and CA $253 for one-way flights to Sikeston for the period specified. Prices and availability are subject to change. Additional terms apply

OriginDestinationTravel datesFlights from*
DFWSt. LouisAugust 21 to August 28CA $206
ATLSt. LouisAugust 15 to August 17CA $229
SEASt. LouisAugust 19 to August 26CA $246
TPASt. LouisAugust 14 to August 18CA $254
EWRSt. LouisAugust 9 to August 10CA $413
LGASt. LouisAugust 9 to August 10CA $481
DENSt. LouisSeptember 20 to September 27CA $633
*Prices include taxes and fees
OriginDestinationTravel datesFlights from*
SEASt. LouisAugust 3 to August 5CA $810
*Prices include taxes and fees

Your guide to flights to Sikeston, MO

American Airlines fly to Sikeston, so use Travelocity to search, find, and compare some truly tempting deals from the 2 airlines—that way you can be sure you’ve found the best deal for you. A flight to Sikeston MO currently costs between CA $206 and CA $810. Prices vary, but for the best fares, travel in September when prices are at their lowest.  

Top tips for finding cheap flights to Sikeston  

The cheapest flight for a round trip to Sikeston is currently CA $206. When you search for flights to Sikeston, enter your preferred travel dates then click on ‘flexible dates’ to compare cheap flight tickets to Sikeston for nearby days.  The cheapest month to travel to Sikeston is November from our list of deals available.  

But if you’re flexible about when you travel, you can find great deals on flights across the year. If you’re planning a vacation, you can save more on Travelocity when you bundle flights with car rental and hotel bookings, too. Many airlines currently offer flexible booking options, so look for flights offering no change fees.   

How to cancel flights to Sikeston 

We know plans change, that’s why at Travelocity, we make it as easy as possible for you to cancel or amend your plane tickets. Go to My Trips, enter your itinerary number, then follow the instructions. Many airlines let you cancel flights online free of charge if you booked it in the last 24 hours. Visit Customer Service for more advice.  

Why you should book your flight to Sikeston with Travelocity 

We have top deals on plane tickets even for last minute flights to Sikeston, so you can simply type in your travel dates and compare our best prices. Booking with Travelocity means you get flexible cancellation options, 24/7 support, and, thanks to our Price Match Promise, if the airfare drops after you book, you can get a refund! Whether you’re planning a business trip, weekend getaway, or a family vacation—let Travelocity get you to Sikeston for less. 

Find The Perfect Hotel For After Your Flight

Amazing Place to Stay After Flight to Sikeston

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
The price is CA $110 per night from Jul 31 to Aug 1
CA $110
CA $126 total
Jul 31 - Aug 1
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,008 reviews)
Nice hotel.
"Very nice hotel. Very friendly and clean. Breakfast was good. Will stay here again when back in region."

Reviewed on Jul. 25, 2025

Pear Tree Inn Sikeston
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
The price is CA $96 per night from Aug 5 to Aug 6
CA $96
CA $108 total
Aug 5 - Aug 6
includes taxes & fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,008 reviews)
"We enjoyed the quick check in and how quiet the property was."

Reviewed on Jul. 21, 2025

Pear Tree Inn Cape Girardeau West
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr, Sikeston, MO
The price is CA $99 per night from Aug 4 to Aug 5
CA $99
CA $113 total
Aug 4 - Aug 5
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,005 reviews)
Nice, comfortable
"The staff and room were nice. I did not like that they actually took a deposit out of my account and put it back instead of just held it like other hotels I've been at."

Reviewed on Jul. 26, 2025

Days Inn and Suites by Wyndham Sikeston
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Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 out of 5
3253 William Street, Cape Girardeau, MO
The price is CA $141 per night from Aug 17 to Aug 18
CA $141
CA $160 total
Aug 17 - Aug 18
includes taxes & fees
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,009 reviews)
"Breakfast"

Reviewed on Jul. 28, 2025

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury Hotels in Sikeston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr, Sikeston, MO
The price is CA $99 per night from Aug 4 to Aug 5
CA $99
CA $113 total
Aug 4 - Aug 5
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,005 reviews)
Nice, comfortable
"The staff and room were nice. I did not like that they actually took a deposit out of my account and put it back instead of just held it like other hotels I've been at."

Reviewed on Jul. 26, 2025

Days Inn and Suites by Wyndham Sikeston
Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau
Stay at this apartment in Cape Girardeau. Enjoy free WiFi, a water park, and laundry facilities. Popular attractions Riverfront Park and eDen Spa & Salon are ...
9.8/10 Exceptional! (167 reviews)
Great stay!
"The location could not be better! The view of the Mississippi River from the balcony is spectacular. The house is on the edge of downtown which makes it easy to see the Wall of art and history, all the shops and restaurants. We loved Cape Girardeau, as it’s fairly easy to get around through the ..."

Reviewed on Jul. 6, 2025

Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 out of 5
3248 William St, Cape Girardeau, MO
The price is CA $96 per night from Aug 3 to Aug 4
CA $96
CA $108 total
Aug 3 - Aug 4
includes taxes & fees
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (1,010 reviews)
Super Facility Near The Medical Center!
"I have stayed at this Hotel several times when I have had early morning reporting times at St. Francis Medical Center. Each time it has been great. Friendly staff quiet atmosphere and great rooms with comfortable furnishings."

Reviewed on Jul. 29, 2025

Pear Tree Inn Cape Girardeau Near the Medical Center
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Quality Inn

Quality Inn

2.5 out of 5
2011 North Kingshighway, Cape Girardeau, MO
The price is CA $83 per night from Aug 5 to Aug 6
CA $83
CA $94 total
Aug 5 - Aug 6
includes taxes & fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
7/10 Good! (617 reviews)
"A/c unit"

Reviewed on Jul. 24, 2025

Quality Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Sikeston

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
The price is CA $124 per night from Aug 17 to Aug 18
CA $124
CA $142 total
Aug 17 - Aug 18
includes taxes & fees
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,000 reviews)
"Enjoyed everything"

Reviewed on Jul. 19, 2025

Drury Inn & Suites Sikeston, MO
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
The price is CA $110 per night from Jul 31 to Aug 1
CA $110
CA $126 total
Jul 31 - Aug 1
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,008 reviews)
Nice hotel.
"Very nice hotel. Very friendly and clean. Breakfast was good. Will stay here again when back in region."

Reviewed on Jul. 25, 2025

Pear Tree Inn Sikeston
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive, Sikeston, MO
The price is CA $121 per night from Aug 24 to Aug 25
CA $121
CA $138 total
Aug 24 - Aug 25
includes taxes & fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,014 reviews)
"It was clean & nice, but the person greeting us was not very personable, just rattled off the lines of the hotel policies. It felt like they went cheap on things like toilet paper, kleenex, towels, bathroom sink drain didn't work, bathtub was slippery, and no charging ports for electronics, just ..."

Reviewed on Jul. 29, 2025

Best Western Plus Sikeston
Save an average of 15% on thousands of hotels when you're signed in
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive, Cape Girardeau, MO
The price is CA $124 per night from Aug 3 to Aug 4
CA $124
CA $139 total
Aug 3 - Aug 4
includes taxes & fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (963 reviews)
"Love the property. Staff is always amazing."

Reviewed on Jul. 21, 2025

Drury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best Sikeston Flight and Hotel Packages

Sikeston flight + hotel packages - economy flights

Price found within the past 48 hours. Click for updated prices.
Capitol Plaza Hotel Jefferson City
Isle of Capri Casino Hotel Boonville
Quality Inn & Suites Boonville - Columbia
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Need a car after flight to Sikeston?

Frequently asked questions

Which airlines fly to Sikeston?
You won't find many airlines that service Sikeston. So, if you're planning to embark on your long-anticipated adventure from here, book a seat with Cape Air as soon as you can.
Where to stay in Sikeston
Lock in your Sikeston accommodations through Travelocity and then turn your attention to what really matters — creating remarkable travel memories. Pick from 12 lodgings from which you can explore this enticing destination.If you're on the hunt for the top accommodation options in Sikeston, we suggest the Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel and the Hampton Inn Sikeston. Reserve a room and then start booking all your exciting getaway activities.
Places to visit in Sikeston
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How to get through airport security fast when traveling to Sikeston
Your adventure to Sikeston starts as soon as you've finished all the security checks. Here are some tips and pointers to help you get through quickly:

  • Security personnel will ask to see your travel ID and boarding pass as part of their checks. Tuck them away in a convenient place, so they're all ready for inspection.
  • Remove your shoes and belt before arriving at the airport security checkpoint. Items like these are not permitted to pass through the body scanner.
  • Make sure your phone, laptop and other electronic devices are easily accessible. These items need to be sent through the X-ray machine separately.
  • When you approach the security checkpoint, you'll be asked to place all creams, gels and liquids in a separate tray for scanning. Make sure they're all packed in containers smaller than 3.4 ounces (100 milliliters) and sealed in a clear zip-lock bag.
  • Security personnel will likely tell you to take off your shoes for the body scanner. Choose a pair that you can slip off easily. There's nothing more irritating than having to do your laces up over and over again.
  • Pocketknives and corkscrews are not permitted on board the aircraft. Tuck them away in your checked luggage to avoid them being confiscated at the airport security checkpoint.

Plane Tickets To Sikeston

Although you may try and resist the urge, you know that when the travel bug comes, there is only one way to get rid of it. Thankfully, Travelocity is here to help nip that travel bug in the bud with great deals on flights to Sikeston. Browse through our inventory to explore a wide range of cheap flights to Sikeston to solidify your next big trip out of town. Whether you are heading out on a business trip, exploring a place you have never been for pleasure or are bringing the family on the annual vacation, we have the perfect getaway waiting for you. In no time, you will be day dreaming of your plane landing in Sikeston as you anxiously await to exit the plane and explore what Sikeston has to offer. Considering all the amazing local food and culture in Sikeston, we won't hold this against you.

When you are ready to embark on your next big adventure, Travelocity will be right here waiting to open the doors to the garden so that you can go and smell the roses. When you decide to book and travel is entirely up to you, but don't wait too long because we have some of the best deals on the web and they won't last long. Take time to go through our huge selection of cheap flights to Sikeston to find the best deals that fit into your budget. If browsing on your phone while your boss isn't looking is more your thing (we promise we won't tell), consider checking out Travelocity's mobile app which allows you to take advantage of all our flights to Sikeston without having to compromise your work computer's search history. If you are looking to save even more, you can easily save up to $537 when you bundle one of our cheap flights to Sikeston with one of our hotels. So why are you waiting around? There is no better time than now to start booking that next trip. Start your search now to book one of our flights to Sikeston today!

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.