Find and compare 5 Star hotels in Panama City

Name: Hilton Panama
Price range: CA $250
Rating: 8.8

Wander Wisely with exceptional service, 24/7 support

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Featured Panama City 5 Star hotels

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella, Panama City, Panama

Fully refundableReserve now, pay when you stay

CA $166

CA $183 total

Nov 24 - Nov 25

includes taxes & fees

Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...

9/10 Wonderful! (4,491 reviews)

Staff very friendly and helpful

Reviewed on Nov 11, 2025

Waldorf Astoria Panama

47th St. & Uruguay Street, Panama City, Panama

Fully refundableReserve now, pay when you stay

CA $240

CA $264 total

Dec 1 - Dec 2

includes taxes & fees

Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...

8.8/10 Excellent! (1,002 reviews)

Very beautiful room was spotless, and staff was very good with customer service

Reviewed on Nov 7, 2025

JW Marriott Panama

Calle Punta Colon, Punta Pacifica, Panama City, Panama

Fully refundableReserve now, pay when you stay

CA $276

CA $304 total

Dec 7 - Dec 8

includes taxes & fees

Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...

8.8/10 Excellent! (1,002 reviews)

The receptionist and all the staff were very helpful. The property and room was stunning. Loved the pools and the gym. Would definitely stay here again.

Reviewed on Nov 7, 2025

W Panama

Calle Aquilino de la Guardia & Calle 50, Bella Vista, Panama City

Fully refundableReserve now, pay when you stay

CA $241

CA $265 total

Dec 13 - Dec 14

includes taxes & fees

Stay at this 5-star luxury hotel in Panama City. Enjoy 2 restaurants, 3 hot tubs, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular ...

8.8/10 Excellent! (1,007 reviews)

Clean room, great views, great staff!

Reviewed on Nov 10, 2025

Sofitel Legend Casco Viejo, Panama City

Calle Primera Oeste, San Felipe, Panama City, Panama

Fully refundableReserve now, pay when you stay

CA $416

CA $458 total

Dec 14 - Dec 15

includes taxes & fees

Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property ...

9.8/10 Exceptional! (525 reviews)

We stayed at Sofitel Legend Casco Viejo for our anniversary, and it was perfect! The staff surprised us with a beautiful anniversary detail that made our stay so special. The hotel is stunning, peaceful, and spotless — everything was perfectly clean and well kept. Everyone was kind and attentive, ...

Reviewed on Oct 19, 2025

Bristol Panama, a Registry Collection Hotel

Avenida Aquilino de La Guardia, Bella Vista, Panama City, Panama

Fully refundableReserve now, pay when you stay

CA $223

CA $245 total

Dec 6 - Dec 7

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff and the property ...

9.2/10 Wonderful! (1,003 reviews)

Everything was good. We were satisfied

Reviewed on Nov 8, 2025

The Westin Playa Bonita Panama

Km 6 Road to Veracruz, Veracruz, Panama

Fully refundableReserve now, pay when you stay

CA $233

CA $256 total

Dec 10 - Dec 11

includes taxes & fees

Stay at this 5-star luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...

8/10 Very Good! (1,002 reviews)

The lobby smells amazing!

Reviewed on Nov 8, 2025

Renaissance Panama City Hotel

Via España & Ricardo Arias Street, Panama City, Panama

Fully refundableReserve now, pay when you stay

CA $163

CA $179 total

Nov 21 - Nov 22

includes taxes & fees

Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a casino. Popular attractions Albrook Shopping Mall and Via Espana ...

9/10 Wonderful! (80 reviews)

Great location and amazing staff

Reviewed on Nov 10, 2025

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Santa Maria Boulevard, Panama City

Fully refundableReserve now, pay when you stay

CA $251

CA $276 total

Dec 13 - Dec 14

includes taxes & fees

Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...

9.6/10 Exceptional! (624 reviews)

This is a quality hotel with quality service. Recommend it

Reviewed on Oct 30, 2025

Hilton Panama

Balboa Ave. and Aquilino De La Guardia, Panama City

Fully refundableReserve now, pay when you stay

CA $250

CA $275 total

Dec 7 - Dec 8

includes taxes & fees

Stay at this 5-star luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the helpful staff in our ...

8.8/10 Excellent! (1,000 reviews)

This hotel is perfection - in every respect. The best location, best amenities, awesome food, great entertainment, excellent service.

Reviewed on Oct 16, 2025

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Five Star Hotels in Panama City

Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.