Find and compare 5 Star hotels in Panama City

Name: The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Price range: CA $364
Rating: 9.6

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Featured Panama City 5 Star hotels

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama

Fully refundableReserve now, pay when you stay

CA $161

CA $177 total

Feb 4 - Feb 5

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...

9/10 Wonderful! (4,840 reviews)

Very nice hotel and room with lots of amenities. Only stayed one night for a quick trip to the airport in the morning.

Reviewed on Jan 16, 2026

Waldorf Astoria Panama

47th St. & Uruguay Street Panama City Panama

CA $306

CA $337 total

Feb 6 - Feb 7

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...

8.8/10 Excellent! (1,002 reviews)

Yes the room was spotless and syaff was very attentive and courteous

Reviewed on Jan 8, 2026

W Panama

Calle Aquilino de la Guardia & Calle 50 Panama City

Fully refundableReserve now, pay when you stay

CA $277

CA $304 total

Jan 30 - Jan 31

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy 2 restaurants, 3 hot tubs, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular ...

8.8/10 Excellent! (1,002 reviews)

I had a wonderful stay at the W Hotel. The rooms were spacious and nicely decorated, I loved the breakfast from room service!!

Reviewed on Jan 10, 2026

JW Marriott Panama

Calle Punta Colon, Punta Pacifica Panama City Panama

CA $402

CA $442 total

Feb 7 - Feb 8

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...

8.8/10 Excellent! (1,004 reviews)

Clean room

Reviewed on Jan 8, 2026

Sofitel Legend Casco Viejo, Panama City

Calle Primera Oeste, San Felipe Panama City Panama

Fully refundableReserve now, pay when you stay

CA $455

CA $500 total

Feb 1 - Feb 2

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property ...

9.8/10 Exceptional! (572 reviews)

The staf, the people on the main entrance door, the concierne, everything is perfect.

Reviewed on Jan 5, 2026

Hilton Panama

Balboa Ave. and Aquilino De La Guardia Panama City

CA $287

CA $315 total

Feb 15 - Feb 16

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the helpful staff in our ...

8.8/10 Excellent! (1,000 reviews)

Amazing location in downtown Panama City. Staff is super

Reviewed on Jan 4, 2026

The Westin Playa Bonita Panama

Km 6 Road to Veracruz Veracruz Panama

Fully refundableReserve now, pay when you stay

CA $353

CA $389 total

Jan 25 - Jan 26

includes taxes & fees

Book a stay at this luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...

8/10 Very Good! (1,000 reviews)

The property was in a beautiful spot with a gorgeous of the ocean. The water recedes in the day but don’t worry it comes back by the morning. The food is good - good variety. One thing I will point out. Bring your insect repellant. There are microscopic insects (mosquitoes) that come out from 6pm-6am ...

Reviewed on Jan 10, 2026

Renaissance Panama City Hotel

Via España & Ricardo Arias Street Panama City Panama

Fully refundableReserve now, pay when you stay

CA $176

CA $194 total

Jan 30 - Jan 31

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a casino. Popular attractions Albrook Shopping Mall and Avenida Balboa ...

8.8/10 Excellent! (118 reviews)

It was a great stay. They are very kind and love to help. TERRIFIC STAFF!!!!!!

Reviewed on Jan 12, 2026

Bristol Panama, a Registry Collection Hotel

Avenida Aquilino de La Guardia Panama City Panama

Fully refundableReserve now, pay when you stay

CA $274

CA $302 total

Feb 16 - Feb 17

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...

9.2/10 Wonderful! (1,000 reviews)

La piscine est toute petite. Le quartier est peu agréable pour marcher

Reviewed on Jan 12, 2026

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Santa Maria Boulevard Panama City

CA $364

CA $400 total

Feb 6 - Feb 7

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...

9.6/10 Exceptional! (654 reviews)

this is the best place to stay near the airport. great rooms, fantastic staff. The best breakfast ever! this is not my first time at Santa Maria and definitely not the last!!!

Reviewed on Dec 11, 2025

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Five Star Hotels in Panama City

Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.