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Featured Panama City 5 Star hotels

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $167 per night from Dec 7 to Dec 8
CA $167
CA $184 total
Dec 7 - Dec 8
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (4,564 reviews)
Excellent service great place to stay rate this place 💯 great buffet breakfast would definitely be back

Reviewed on Nov 23, 2025

Opens in a new windowHotel Riu Plaza Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $242 per night from Dec 6 to Dec 7
CA $242
CA $266 total
Dec 6 - Dec 7
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (1,004 reviews)
The service was excellent but the installations need a renovation, in my opinion.

Reviewed on Nov 22, 2025

Opens in a new windowWaldorf Astoria Panama
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
The price is CA $247 per night from Dec 5 to Dec 6
CA $247
CA $272 total
Dec 5 - Dec 6
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy 2 restaurants, 3 hot tubs, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,002 reviews)
The staff was exceptional, the suite I got was everything plus more of what I expected! 10/10, highly recommend! Loved the panoramic views!

Reviewed on Nov 17, 2025

Opens in a new windowW Panama
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $311 per night from Dec 5 to Dec 6
CA $311
CA $342 total
Dec 5 - Dec 6
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,007 reviews)
Fabulous stay!

Reviewed on Nov 20, 2025

Opens in a new windowJW Marriott Panama
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Calle Primera Oeste, San Felipe Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $539 per night from Nov 30 to Dec 1
CA $539
CA $593 total
Nov 30 - Dec 1
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property ...
9.8/10 Exceptional! (535 reviews)
Gorgeous, historic hotel on the ocean with views across the water to downtown. Service was impeccable and food and drink delicious.

Reviewed on Nov 16, 2025

Opens in a new windowSofitel Legend Casco Viejo, Panama City
Hilton Panama

Hilton Panama

5 out of 5
Balboa Ave. and Aquilino De La Guardia Panama City
Fully refundableReserve now, pay when you stay
The price is CA $253 per night from Dec 7 to Dec 8
CA $253
CA $278 total
Dec 7 - Dec 8
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the helpful staff in our ...
8.8/10 Excellent! (1,002 reviews)
Great size room, very clean, staff are all friendly. Good choices at the breakfast buffet. I usually stay here for business and it’s always pleasant.

Reviewed on Nov 14, 2025

Opens in a new windowHilton Panama
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5 out of 5
Km 6 Road to Veracruz Veracruz Panama
Fully refundableReserve now, pay when you stay
The price is CA $235 per night from Dec 14 to Dec 15
CA $235
CA $258 total
Dec 14 - Dec 15
includes taxes & fees
Book a stay at this luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8/10 Very Good! (1,003 reviews)
The hotel needs to be refresh missing buttons in the elevator in some shaft, they to fix our AC twice , feels dated ..nice staff

Reviewed on Nov 21, 2025

Opens in a new windowThe Westin Playa Bonita Panama
Renaissance Panama City Hotel

Renaissance Panama City Hotel

5 out of 5
Via España & Ricardo Arias Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $155 per night from Dec 6 to Dec 7
CA $155
CA $170 total
Dec 6 - Dec 7
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a casino. Popular attractions Albrook Shopping Mall and Avenida Balboa ...
8.8/10 Excellent! (90 reviews)
Great service staff.

Reviewed on Nov 19, 2025

Opens in a new windowRenaissance Panama City Hotel
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
Avenida Aquilino de La Guardia Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $252 per night from Dec 19 to Dec 20
CA $252
CA $277 total
Dec 19 - Dec 20
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,006 reviews)
Super team. Danay always makes my stay wonderful as does the whole team. I go often.

Reviewed on Nov 16, 2025

Opens in a new windowBristol Panama, a Registry Collection Hotel
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
Santa Maria Boulevard Panama City
Fully refundableReserve now, pay when you stay
The price is CA $306 per night from Dec 24 to Dec 25
CA $306
CA $336 total
Dec 24 - Dec 25
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (632 reviews)
los felicito excelente el servicio y la atencion

Reviewed on Nov 17, 2025

Opens in a new windowThe Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
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Five Star Hotels in Panama City

Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Panama City hotel reviews by fellow wanderers