Find and compare 5 Star hotels in Panama City

Start date: Check-in selected.
To Date
End date: Check-out

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Featured Panama City 5 Star hotels

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $161 per night from Feb 4 to Feb 5
CA $161
CA $177 total
Feb 4 - Feb 5
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (4,840 reviews)
Very nice hotel and room with lots of amenities. Only stayed one night for a quick trip to the airport in the morning.

Reviewed on Jan 16, 2026

Opens in a new windowHotel Riu Plaza Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
The price is CA $306 per night from Feb 6 to Feb 7
CA $306
CA $337 total
Feb 6 - Feb 7
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (1,002 reviews)
Yes the room was spotless and syaff was very attentive and courteous

Reviewed on Jan 8, 2026

Opens in a new windowWaldorf Astoria Panama
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
The price is CA $277 per night from Jan 30 to Jan 31
CA $277
CA $304 total
Jan 30 - Jan 31
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy 2 restaurants, 3 hot tubs, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,002 reviews)
I had a wonderful stay at the W Hotel. The rooms were spacious and nicely decorated, I loved the breakfast from room service!!

Reviewed on Jan 10, 2026

Opens in a new windowW Panama
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
The price is CA $402 per night from Feb 7 to Feb 8
CA $402
CA $442 total
Feb 7 - Feb 8
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,004 reviews)
Clean room

Reviewed on Jan 8, 2026

Opens in a new windowJW Marriott Panama
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5 out of 5
Calle Primera Oeste, San Felipe Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $455 per night from Feb 1 to Feb 2
CA $455
CA $500 total
Feb 1 - Feb 2
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property ...
9.8/10 Exceptional! (572 reviews)
The staf, the people on the main entrance door, the concierne, everything is perfect.

Reviewed on Jan 5, 2026

Opens in a new windowSofitel Legend Casco Viejo, Panama City
Hilton Panama

Hilton Panama

5 out of 5
Balboa Ave. and Aquilino De La Guardia Panama City
The price is CA $287 per night from Feb 15 to Feb 16
CA $287
CA $315 total
Feb 15 - Feb 16
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the helpful staff in our ...
8.8/10 Excellent! (1,000 reviews)
Amazing location in downtown Panama City. Staff is super

Reviewed on Jan 4, 2026

Opens in a new windowHilton Panama
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5 out of 5
Km 6 Road to Veracruz Veracruz Panama
Fully refundableReserve now, pay when you stay
The price is CA $353 per night from Jan 25 to Jan 26
CA $353
CA $389 total
Jan 25 - Jan 26
includes taxes & fees
Book a stay at this luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8/10 Very Good! (1,000 reviews)
The property was in a beautiful spot with a gorgeous of the ocean. The water recedes in the day but don’t worry it comes back by the morning. The food is good - good variety. One thing I will point out. Bring your insect repellant. There are microscopic insects (mosquitoes) that come out from 6pm-6am ...

Reviewed on Jan 10, 2026

Opens in a new windowThe Westin Playa Bonita Panama
Renaissance Panama City Hotel

Renaissance Panama City Hotel

5 out of 5
Via España & Ricardo Arias Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $176 per night from Jan 30 to Jan 31
CA $176
CA $194 total
Jan 30 - Jan 31
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a casino. Popular attractions Albrook Shopping Mall and Avenida Balboa ...
8.8/10 Excellent! (118 reviews)
It was a great stay. They are very kind and love to help. TERRIFIC STAFF!!!!!!

Reviewed on Jan 12, 2026

Opens in a new windowRenaissance Panama City Hotel
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
Avenida Aquilino de La Guardia Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $274 per night from Feb 16 to Feb 17
CA $274
CA $302 total
Feb 16 - Feb 17
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,000 reviews)
La piscine est toute petite. Le quartier est peu agréable pour marcher

Reviewed on Jan 12, 2026

Opens in a new windowBristol Panama, a Registry Collection Hotel
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5 out of 5
Santa Maria Boulevard Panama City
The price is CA $364 per night from Feb 6 to Feb 7
CA $364
CA $400 total
Feb 6 - Feb 7
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (654 reviews)
this is the best place to stay near the airport. great rooms, fantastic staff. The best breakfast ever! this is not my first time at Santa Maria and definitely not the last!!!

Reviewed on Dec 11, 2025

Opens in a new windowThe Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Don't see what you're looking for?
See all available properties in Panama City
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Five Star Hotels in Panama City

Looking for your own little slice of heaven during your next trip? Check out all the best 5 star hotels in Panama City to make sure your trip is as extravagantly comfortable as you expect.

Whether you plan on staying in your room the whole time or getting out and enjoying the city, you’ll be living the life while staying at your luxury accommodation. With so many amenities at your beck and call, you might try to turn your stay into a staycation!

Many of the five star hotels have award-winning restaurants you can dine at, as well as plush bedding and a concierge service to take care of your every need. Most also offer pools and modern fitness centers, not to mention high-speed Wi-Fi.

For your next trip, book a hotel that can be your own little hideaway, whether you’re in town for business or leisure. Panama City 5 star hotels provide you with all the comforts and amenities you expect from a sophisticated hotel, with a staff that’s happy to ensure you have everything you need to feel at home.

Whether you’re a first-time guest, or you’ve stayed in 5 star hotels in Panama City before, you’ll have no shortage of options to choose from on your next trip when you book with Travelocity. Browse our vast selection and find great deals on luxury lodging.

Recent Panama City hotel reviews by fellow wanderers