Find and compare 4 Star hotels in Florida Keys
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Featured Florida Keys 4 Star hotels
Reefhouse Resort & Marina
103800 Overseas Hwy Key Largo FL
Fully refundableReserve now, pay when you stay
The price is CA $409 per night from Apr 20 to Apr 21
CA $409
CA $515 total
Apr 20 - Apr 21
includes taxes & fees
Book a stay at this luxury hotel in Key Largo. Enjoy free parking, a full-service spa, and 3 restaurants. Our guests praise the pool and the helpful staff in ...
9.2/10 Wonderful! (1,407 reviews)
This resort has breathtaking views!!
Reviewed on Apr 18, 2026
Baker's Cay Resort Key Largo, Curio Collection by Hilton
97000 Overseas Hwy Key Largo FL
Fully refundableReserve now, pay when you stay
The price is CA $482 per night from Apr 27 to Apr 28
CA $482
CA $617 total
Apr 27 - Apr 28
includes taxes & fees
Book a stay at this beach resort in Key Largo. Enjoy 2 outdoor pools, 2 restaurants, and a private beach. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,039 reviews)
Na
Reviewed on Apr 18, 2026
Amara Cay Resort
80001 Overseas Hwy Islamorada FL
Fully refundableReserve now, pay when you stay
The price is CA $319 per night from Apr 21 to Apr 22
CA $319
CA $458 total
Apr 21 - Apr 22
includes taxes & fees
Book a stay at this beach resort in Islamorada. Enjoy 2 restaurants, a private beach, and 3 bars/lounges. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (1,264 reviews)
No clean room every day
Reviewed on Apr 16, 2026
Hawks Cay Resort
61 Hawks Cay Blvd Marathon FL
Fully refundableReserve now, pay when you stay
The price is CA $418 per night from May 17 to May 18
CA $418
CA $566 total
May 17 - May 18
includes taxes & fees
Book a stay at this luxury hotel in Marathon. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8/10 Very Good! (1,007 reviews)
The gentleman at the adult pool was Andre was a very nice man as was the guy Kim who drove the cart . The drink prices were too expensive we finally went out and got our own drinks. 8-9 dollars for a beer is outrageous when you can buy your own for a dollar each. The property and views were great ...
Reviewed on Apr 18, 2026
Islander Resort
82100 Overseas Highway Islamorada FL
Fully refundableReserve now, pay when you stay
The price is CA $292 per night from May 17 to May 18
CA $292
CA $421 total
May 17 - May 18
includes taxes & fees
Book a stay at this beach hotel in Islamorada. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the pool and the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,002 reviews)
Beautiful resort, but we had roaches in our room. The manager did not appear to really care.
Reviewed on Apr 16, 2026
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
1996 Overseas Highway Marathon FL
Fully refundableReserve now, pay when you stay
The price is CA $336 per night from May 3 to May 4
CA $336
CA $429 total
May 3 - May 4
includes taxes & fees
Book a stay at this spa resort in Marathon. Enjoy free WiFi, 4 outdoor pools, and a full-service spa. Our guests praise the pool and the restaurant in our reviews. ...
8.8/10 Excellent! (1,168 reviews)
For a two night stay, 3 rooms. Totaling over $4,000, what do you think? Worms in room, cockroaches at entrance, toilet paper so thin you might as well use bare fingers, towels that can rub your skin off, service at coffee stand that took forever, noise from across the hall all night. $50 to park ...
Reviewed on Apr 12, 2026
Playa Largo Resort & Spa, Autograph Collection
97450 Overseas Highway Key Largo FL
Fully refundableReserve now, pay when you stay
The price is CA $492 per night from May 3 to May 4
CA $492
CA $628 total
May 3 - May 4
includes taxes & fees
Book a stay at this luxury resort in Key Largo. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (1,003 reviews)
The restaurants were great and room was clean. The staff was very attentive and nice. Our room was on the first floor and our room was really cold so that was the only downfall. We really enjoyed our stay! Beautiful water!!
Reviewed on Apr 16, 2026
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
84001 Overseas Hwy Islamorada FL
The price is CA $336 per night from May 4 to May 5
CA $336
CA $469 total
May 4 - May 5
includes taxes & fees
Book a stay at this beach resort in Islamorada. Enjoy free WiFi, 3 outdoor pools, and 4 restaurants. Our guests praise the helpful staff and the clean rooms ...
9/10 Wonderful! (185 reviews)
We loved everthing about this resort! We just wish we had stayed longer! We stayed in The Cove. It was secluded and quiet! A perfect get away!
Reviewed on Apr 16, 2026
La Siesta Resort & Villas
80241 Overseas Highway Islamorada FL
Fully refundableReserve now, pay when you stay
The price is CA $282 per night from Apr 30 to May 1
CA $282
CA $417 total
Apr 30 - May 1
includes taxes & fees
Book a stay at this beach resort in Islamorada. Enjoy a private beach, a marina, and breakfast (surcharge). Our guests praise the helpful staff and the spacious ...
8.6/10 Excellent! (1,005 reviews)
Pool was way too warm and heaters still running. Hidden fees. No glass
Reviewed on Apr 18, 2026
Tranquility Bay Beachfront Hotel and Resort
2600 Overseas Hwy Marathon FL
Fully refundableReserve now, pay when you stay
The price is CA $393 per night from May 10 to May 11
CA $393
CA $531 total
May 10 - May 11
includes taxes & fees
Book a stay at this beach hotel in Marathon. Enjoy free WiFi, free parking, and 3 outdoor pools. Our guests praise the pool and the helpful staff in our reviews. ...
8.8/10 Excellent! (1,000 reviews)
Prepare for expensive meals and drinks.
Reviewed on Apr 3, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
4 Star Hotels Florida Keys
Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?
Come on, you deserve it!
The best part about staying in Florida Keys 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.
Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.
The best four star hotels in Florida Keys will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!
If you’re looking for 4 star hotels in Florida Keys, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.
Recent Florida Keys hotel reviews by fellow wanderers
Cheeca Lodge & Spa
2 out of 5
Posted 3 hours ago
Travelocity Verified Review
"Definitely not a 4-star experience and far from worth $1,000+ per night.
The room lacked basic amenities—there was no shampoo provided, and I had to use shower gel instead. The hair dryer was also broken, and despite reporting it, no replacement was offered.
The beach conditions were disappointing as well, with significant seaweed both on the shore and in the water, making it far from enjoyable.
Overall, this stay did not meet expectations for the price point, and I would not recommend it."
A verified traveller stayed at Cheeca Lodge & Spa
