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Featured Florida Keys 4 Star hotels

Hawks Cay Resort

Hawks Cay Resort

4 out of 5
61 Hawks Cay Blvd Marathon FL
Fully refundableReserve now, pay when you stay
The price is CA $619 per night from Mar 2 to Mar 3
CA $619
CA $792 total
Mar 2 - Mar 3
includes taxes & fees
Book a stay at this luxury hotel in Marathon. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8/10 Very Good! (1,018 reviews)
Staff

Reviewed on Feb 23, 2026

Opens in a new windowHawks Cay Resort
Amara Cay Resort

Amara Cay Resort

4 out of 5
80001 Overseas Hwy Islamorada FL
The price is CA $394 per night from Mar 4 to Mar 5
CA $394
CA $544 total
Mar 4 - Mar 5
includes taxes & fees
Book a stay at this beach resort in Islamorada. Enjoy 2 restaurants, a private beach, and 3 bars/lounges. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (1,266 reviews)
Room had a musty odor. Tiki bar staff non attentive. Grounds were beautiful

Reviewed on Feb 22, 2026

Opens in a new windowAmara Cay Resort
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton

4 out of 5
97000 Overseas Hwy Key Largo FL
Fully refundableReserve now, pay when you stay
The price is CA $587 per night from Feb 25 to Feb 26
CA $587
CA $736 total
Feb 25 - Feb 26
includes taxes & fees
Book a stay at this beach resort in Key Largo. Enjoy 2 outdoor pools, 2 restaurants, and a private beach. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,006 reviews)
The room was nice. It was nice to have two separate pools. We thought they could have explained the service charges better. 20% was automatically added to everything including asking for a soda, drinks, food and we initially tipped on top of that. The place was packed and it would have liked to have ...

Reviewed on Feb 23, 2026

Opens in a new windowBaker's Cay Resort Key Largo, Curio Collection by Hilton
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

4.5 out of 5
97450 Overseas Highway Key Largo FL
Fully refundableReserve now, pay when you stay
The price is CA $587 per night from Feb 25 to Feb 26
CA $587
CA $736 total
Feb 25 - Feb 26
includes taxes & fees
Book a stay at this luxury resort in Key Largo. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (1,003 reviews)
Absolutely 10/10 would recommend! One of the best hotels in key largo, service was spectacular. the bartenders in the restaurant go out of their way to service you, want to thank Javier in particular who made our night! Can’t wait to return ! Very family friendly as well.

Reviewed on Feb 23, 2026

Opens in a new windowPlaya Largo Resort & Spa, Autograph Collection
Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton

Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton

4 out of 5
1996 Overseas Highway Marathon FL
Fully refundableReserve now, pay when you stay
The price is CA $477 per night from Mar 1 to Mar 2
CA $477
CA $589 total
Mar 1 - Mar 2
includes taxes & fees
Book a stay at this beach resort in Marathon. Enjoy free WiFi, 4 outdoor pools, and a full-service spa. Our guests praise the pool and the restaurant in our ...
8.8/10 Excellent! (1,222 reviews)
First I paid for a king bed room and they didn’t have sold out, then rooms was dirty hair on bed and shower I have proof of that I have pictures

Reviewed on Feb 22, 2026

Opens in a new windowFaro Blanco Resort & Yacht Club Marathon, Curio by Hilton
Islander Resort

Islander Resort

4 out of 5
82100 Overseas Highway Islamorada FL
The price is CA $431 per night from Mar 3 to Mar 4
CA $431
CA $577 total
Mar 3 - Mar 4
includes taxes & fees
Book a stay at this beach hotel in Islamorada. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the pool and the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,009 reviews)
Great resort, easy check in and courteous staff. Nice pools and grounds.

Reviewed on Feb 22, 2026

Opens in a new windowIslander Resort
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

4 out of 5
2600 Overseas Hwy Marathon FL
Fully refundableReserve now, pay when you stay
The price is CA $529 per night from Mar 2 to Mar 3
CA $529
CA $685 total
Mar 2 - Mar 3
includes taxes & fees
Book a stay at this beach hotel in Marathon. Enjoy free WiFi, free parking, and 3 outdoor pools. Our guests praise the pool and the helpful staff in our reviews. ...
8.8/10 Excellent! (1,004 reviews)
Unit needs work. Put us at the end of the resort probably bc I booked thru a third party(Expedia). Smell of sewage prob seaweed. High price food and drinks at beach bar. Tractor on beach in middle of day removing seaweed for 5 day in a row. They allow a tractor noise but no music allowed. . Maid ...

Reviewed on Feb 24, 2026

Opens in a new windowTranquility Bay Beachfront Hotel and Resort
La Siesta Resort & Villas

La Siesta Resort & Villas

4 out of 5
80241 Overseas Highway Islamorada FL
The price is CA $354 per night from Mar 1 to Mar 2
CA $354
CA $499 total
Mar 1 - Mar 2
includes taxes & fees
Book a stay at this beach resort in Islamorada. Enjoy a private beach, a marina, and breakfast (surcharge). Our guests praise the helpful staff and the spacious ...
8.8/10 Excellent! (1,004 reviews)
Our favorite part was the Rum Runner boat taxi. Captain Jen and Mate Bruce weee wonderful.

Reviewed on Feb 21, 2026

Opens in a new windowLa Siesta Resort & Villas
Villas At Hawks Cay Resort

Villas At Hawks Cay Resort

4 out of 5
61 Hawks Cay Boulevard Marathon FL
The price is CA $1,182 per night from Mar 26 to Mar 27
CA $1,182
CA $1,414 total
Mar 26 - Mar 27
includes taxes & fees
Book a stay at this luxury resort in Marathon. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Popular attractions Little Conch Key and Walkers Island ...
8.4/10 Very Good! (165 reviews)
clean villa. great facilities and restaurants!

Reviewed on Feb 21, 2026

Opens in a new windowVillas At Hawks Cay Resort
The Islands of Islamorada

The Islands of Islamorada

4 out of 5
82779 Old Hwy Islamorada FL
The price is CA $1,231 per night from Feb 26 to Feb 27
CA $1,231
CA $1,460 total
Feb 26 - Feb 27
includes taxes & fees
Book a stay at this beach villa in Islamorada. Enjoy free WiFi, free parking, and 2 outdoor pools. Popular attractions History of Diving Museum and Islamorada ...
Opens in a new windowThe Islands of Islamorada
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4 Star Hotels Florida Keys

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Florida Keys 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Florida Keys will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Florida Keys, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.