Find and compare 4 Star hotels in Mainz

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Featured Mainz 4 Star hotels

NH Collection Frankfurt Spin Tower

NH Collection Frankfurt Spin Tower

4.5 out of 5
Güterplatz 1 Frankfurt Hessen
Fully refundableReserve now, pay when you stay
The price is CA $191 per night from Jun 7 to Jun 8
CA $191
CA $210 total
Jun 7 - Jun 8
includes taxes & fees
Book a stay at this luxury hotel in Frankfurt. Enjoy a full-service spa, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
9/10 Wonderful! (658 reviews)
"Loved the location. Can walk to restaurants and the mall is right next door. The hotel is clean and the staff is very accommodating. Breakfast was included and was very good. I would definitely recommend staying there."

Reviewed on May 17, 2026

Opens in a new windowNH Collection Frankfurt Spin Tower
NH Frankfurt Airport

NH Frankfurt Airport

4 out of 5
Moerfelder Strasse 113 Kelsterbach HE
Fully refundableReserve now, pay when you stay
The price is CA $112 per night from Jun 4 to Jun 5
CA $112
CA $126 total
Jun 4 - Jun 5
includes taxes & fees
Book a stay at this business-friendly hotel in Kelsterbach. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the restaurant ...
8.8/10 Excellent! (1,018 reviews)
"Rooms are amazing! Nespresso coffe machine and bed is so comfortable!"

Reviewed on May 22, 2026

Opens in a new windowNH Frankfurt Airport
Radisson Blu Hotel, Frankfurt

Radisson Blu Hotel, Frankfurt

4.5 out of 5
Franklinstr. 65 Frankfurt HE
Fully refundableReserve now, pay when you stay
The price is CA $177 per night from May 30 to May 31
CA $177
CA $195 total
May 30 - May 31
includes taxes & fees
Book a stay at this luxury hotel in Frankfurt. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (692 reviews)
"excellent"

Reviewed on May 11, 2026

Opens in a new windowRadisson Blu Hotel, Frankfurt
Melia Frankfurt City

Melia Frankfurt City

4.5 out of 5
SENCKENBERGANLAGE 13 Frankfurt
Fully refundableReserve now, pay when you stay
The price is CA $197 per night from Jun 14 to Jun 15
CA $197
CA $217 total
Jun 14 - Jun 15
includes taxes & fees
Book a stay at this luxury hotel in Frankfurt. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (552 reviews)
"All good no problems - Clean rooms"

Reviewed on May 8, 2026

Opens in a new windowMelia Frankfurt City
Hotel Monopol

Hotel Monopol

4 out of 5
Mannheimer Str. 11-13 Frankfurt HE
Fully refundableReserve now, pay when you stay
The price is CA $101 per night from May 25 to May 26
CA $101
CA $131 total
May 25 - May 26
includes taxes & fees
Book a stay at this business-friendly hotel in Frankfurt. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,001 reviews)
"The room was in poor condition. The toilet lock didn’t work properly. The shower tub had no doors and the curtain could never block the shower water. It s base was rotten. The most awful thing was the poor sound proofing. I was woken up by the construction work early at seven in the morning."

Reviewed on May 2, 2026

Opens in a new windowHotel Monopol
The Frankfurt Hotel

The Frankfurt Hotel

4 out of 5
Am Hauptbahnhof 2 Frankfurt HE
Fully refundableReserve now, pay when you stay
The price is CA $101 per night from May 26 to May 27
CA $101
CA $115 total
May 26 - May 27
includes taxes & fees
Book a stay at this business-friendly hotel in Frankfurt. Enjoy free WiFi, breakfast (surcharge), and parking (surcharge). Our guests praise the helpful staff ...
8.6/10 Excellent! (1,000 reviews)
"Had an issue with the toilet which wouldn’t flush all weekend and was constantly running but couldn’t be fixed because it was the weekend. Only had feather pillows which I am allergic to and had to fold up a duvet as a pillow as couldn’t offer an alternative. Beggars directly outside hotel was not ..."

Reviewed on May 18, 2026

Opens in a new windowThe Frankfurt Hotel
Capri by Fraser Frankfurt

Capri by Fraser Frankfurt

4.5 out of 5
Europa-Allee 42 Frankfurt
Fully refundableReserve now, pay when you stay
The price is CA $115 per night from Jun 7 to Jun 8
CA $115
CA $129 total
Jun 7 - Jun 8
includes taxes & fees
Book a stay at this luxury hotel in Frankfurt. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,001 reviews)
"Great Hotel"

Reviewed on May 5, 2026

Opens in a new windowCapri by Fraser Frankfurt
Mercure Hotel & Residenz Frankfurt Messe

Mercure Hotel & Residenz Frankfurt Messe

4.5 out of 5
Voltastr. 29 Frankfurt HE
Fully refundableReserve now, pay when you stay
The price is CA $120 per night from Jun 15 to Jun 16
CA $120
CA $135 total
Jun 15 - Jun 16
includes taxes & fees
Book a stay at this luxury hotel in Frankfurt. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions Alte Oper and Frankfurt Christmas ...
8/10 Very Good! (546 reviews)
"Comme chaque année depuis 5 ans, tout se passe bien à l'exception cette année de quelques incidents mineures: chambre demandée en étage élevé, j'étais au rez-de-chaussée; flacon du gel douche/shampoing entièrement vide; fête dans une chambre du personnel juste sous ma chambre le 2ème soir (stoppée ..."

Reviewed on May 22, 2026

Opens in a new windowMercure Hotel & Residenz Frankfurt Messe
Pearl Hotel

Pearl Hotel

4 out of 5
Gutleutstraße 173 Frankfurt HE
Fully refundableReserve now, pay when you stay
The price is CA $109 per night from Jun 21 to Jun 22
CA $109
CA $123 total
Jun 21 - Jun 22
includes taxes & fees
Stay at this hotel in Frankfurt. Enjoy free WiFi, parking (surcharge), and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular ...
Opens in a new windowPearl Hotel
Grand Hotel Downtown

Grand Hotel Downtown

4 out of 5
Taunusstrasse 48- 50 Frankfurt HE
Fully refundableReserve now, pay when you stay
The price is CA $67 per night from May 25 to May 26
CA $67
CA $78 total
May 25 - May 26
includes taxes & fees
Book a stay at this spa hotel in Frankfurt. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
6.6/10 (1,002 reviews)
"shops nearby"

Reviewed on May 20, 2026

Opens in a new windowGrand Hotel Downtown
Don't see what you're looking for?
See all available properties in Mainz
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4 Star Hotels Mainz

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Mainz 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Mainz will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Mainz, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Mainz hotel reviews by fellow wanderers