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Featured Florida Keys 4 Star hotels

Hawks Cay Resort

Hawks Cay Resort

4 out of 5
61 Hawks Cay Blvd Marathon FL
Fully refundableReserve now, pay when you stay
The price is CA $614 per night from Mar 5 to Mar 6
CA $614
CA $786 total
Mar 5 - Mar 6
includes taxes & fees
Book a stay at this luxury hotel in Marathon. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8/10 Very Good! (1,009 reviews)
Had an enjoyable stay, however, for the total expenses of this resort you would expect property conditions to be a little nicer. We had multiple minor issues with our rooms bathroom, the walls are paper thin to the point you can clearly hear your neighboring guests conversations, and rooms lack some ...

Reviewed on Mar 4, 2026

Opens in a new windowHawks Cay Resort
Reefhouse Resort & Marina

Reefhouse Resort & Marina

4.5 out of 5
103800 Overseas Hwy Key Largo FL
Fully refundableReserve now, pay when you stay
The price is CA $477 per night from Mar 5 to Mar 6
CA $477
CA $592 total
Mar 5 - Mar 6
includes taxes & fees
Book a stay at this luxury hotel in Key Largo. Enjoy free parking, a full-service spa, and 3 restaurants. Our guests praise the pool and the helpful staff in ...
9.4/10 Exceptional! (1,398 reviews)
Wonderful location, beautiful view of the sunset. Staff was friendly and helpful. Great restaurants, live music! Two bedroom suite with sitting area, dining area, full kitchen and balcony overlooking the beach and the pool was perfect setting for our girls weekend.

Reviewed on Mar 4, 2026

Opens in a new windowReefhouse Resort & Marina
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

4 out of 5
84001 Overseas Hwy Islamorada FL
Fully refundableReserve now, pay when you stay
The price is CA $587 per night from Mar 5 to Mar 6
CA $587
CA $751 total
Mar 5 - Mar 6
includes taxes & fees
Book a stay at this beach resort in Islamorada. Enjoy free WiFi, 3 outdoor pools, and 4 restaurants. Our guests praise the helpful staff and the clean rooms ...
9/10 Wonderful! (162 reviews)
We had a fantastic stay at Three Waters Resort and Marina. The ocean view room with terrace (Atlantic Shores) was beautiful, and being just steps from the beach and pools made it incredibly easy to relax and enjoy every moment. The included amenities: paddle boards, kayaks, bikes, etc. made it easy ...

Reviewed on Mar 3, 2026

Opens in a new windowThree Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
Amara Cay Resort

Amara Cay Resort

4 out of 5
80001 Overseas Hwy Islamorada FL
Fully refundableReserve now, pay when you stay
The price is CA $398 per night from Mar 8 to Mar 9
CA $398
CA $548 total
Mar 8 - Mar 9
includes taxes & fees
Book a stay at this beach resort in Islamorada. Enjoy 2 restaurants, a private beach, and 3 bars/lounges. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (1,262 reviews)
Staff at reception are rude and unhelpful. They need to cheer up. Food is at best average and expensive.

Reviewed on Mar 4, 2026

Opens in a new windowAmara Cay Resort
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton

4 out of 5
97000 Overseas Hwy Key Largo FL
Fully refundableReserve now, pay when you stay
The price is CA $624 per night from Mar 11 to Mar 12
CA $624
CA $778 total
Mar 11 - Mar 12
includes taxes & fees
Book a stay at this beach resort in Key Largo. Enjoy 2 outdoor pools, 2 restaurants, and a private beach. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,007 reviews)
The amenities and the family-oriented atmosphere make this hotel an excellent place to stay. The natural surroundings are beautiful and create a very relaxing environment. The condition of the hotel was very good, and everything was clean and well maintained. It’s a great place for families to enjoy ...

Reviewed on Mar 4, 2026

Opens in a new windowBaker's Cay Resort Key Largo, Curio Collection by Hilton
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

4 out of 5
1996 Overseas Highway Marathon FL
The price is CA $553 per night from Mar 22 to Mar 23
CA $553
CA $673 total
Mar 22 - Mar 23
includes taxes & fees
Book a stay at this beach resort in Marathon. Enjoy free WiFi, 4 outdoor pools, and a full-service spa. Our guests praise the pool and the restaurant in our ...
8.8/10 Excellent! (1,215 reviews)
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Reviewed on Mar 4, 2026

Opens in a new windowFaro Blanco Resort Marathon Florida Keys, Curio by Hilton
Islander Resort

Islander Resort

4 out of 5
82100 Overseas Highway Islamorada FL
Fully refundableReserve now, pay when you stay
The price is CA $562 per night from Mar 26 to Mar 27
CA $562
CA $725 total
Mar 26 - Mar 27
includes taxes & fees
Book a stay at this beach hotel in Islamorada. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the pool and the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,009 reviews)
Great boutique type hotel with good amenities. Excellent landscaping, lighting and access to amenities.

Reviewed on Mar 2, 2026

Opens in a new windowIslander Resort
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

4.5 out of 5
97450 Overseas Highway Key Largo FL
The price is CA $621 per night from Mar 22 to Mar 23
CA $621
CA $774 total
Mar 22 - Mar 23
includes taxes & fees
Book a stay at this luxury resort in Key Largo. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (1,003 reviews)
The resort is very relaxing and beautiful. The welcome mojito set the vibe. We traveled with our 10 month old infant who had a wonderful time in the pool and beach. The rooms were large and clean. Requested a first floor patio and was assigned one. It really helped not having to do an elevator with ...

Reviewed on Feb 26, 2026

Opens in a new windowPlaya Largo Resort & Spa, Autograph Collection
La Siesta Resort & Villas

La Siesta Resort & Villas

4 out of 5
80241 Overseas Highway Islamorada FL
The price is CA $368 per night from Mar 8 to Mar 9
CA $368
CA $515 total
Mar 8 - Mar 9
includes taxes & fees
Book a stay at this beach resort in Islamorada. Enjoy a private beach, a marina, and breakfast (surcharge). Our guests praise the helpful staff and the spacious ...
8.8/10 Excellent! (1,002 reviews)
Grrat view from room and location is awesome.

Reviewed on Mar 4, 2026

Opens in a new windowLa Siesta Resort & Villas
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

4 out of 5
2600 Overseas Hwy Marathon FL
Fully refundableReserve now, pay when you stay
The price is CA $506 per night from Mar 22 to Mar 23
CA $506
CA $660 total
Mar 22 - Mar 23
includes taxes & fees
Book a stay at this beach hotel in Marathon. Enjoy free WiFi, free parking, and 3 outdoor pools. Our guests praise the pool and the helpful staff in our reviews. ...
8.8/10 Excellent! (1,003 reviews)
The villa was fine although the bedrooms were very tight. The staff was responsive but not proactive. Beautiful campus.

Reviewed on Mar 1, 2026

Opens in a new windowTranquility Bay Beachfront Hotel and Resort
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4 Star Hotels Florida Keys

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Florida Keys 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Florida Keys will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Florida Keys, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Florida Keys hotel reviews by fellow wanderers