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Featured Panama City 4 Star hotels

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

4 out of 5
Via Espana 111 Panama City Panama
The price is CA $147 per night from Mar 23 to Mar 24
CA $147
CA $161 total
Mar 23 - Mar 24
includes taxes & fees
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
7.8/10 Good! (1,015 reviews)
Pool area was restful..

Reviewed on Mar 9, 2026

Opens in a new windowHotel El Panama by Faranda Grand, a member of Radisson Individuals
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Book a stay at this family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
8.6/10 Excellent! (2,490 reviews)
Good hotel to stay at when you have an early morning flight

Reviewed on Mar 10, 2026

Opens in a new windowCrowne Plaza Panama Airport by IHG
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $182 per night from Apr 3 to Apr 4
CA $182
CA $200 total
Apr 3 - Apr 4
includes taxes & fees
Book a stay at this spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
8.6/10 Excellent! (1,008 reviews)
Clean and comfortable room. Bathroom needs an overall. Faucets are hard to open and close.

Reviewed on Mar 7, 2026

Opens in a new windowSheraton Grand Panama
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $225 per night from Apr 1 to Apr 2
CA $225
CA $247 total
Apr 1 - Apr 2
includes taxes & fees
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the helpful staff in ...
9/10 Wonderful! (1,017 reviews)
I could hear the traffic like I was standing outside The toilet keep running,

Reviewed on Mar 9, 2026

Opens in a new windowLas Americas Golden Tower Panama
Marriott Panama Hotel

Marriott Panama Hotel

4 out of 5
Roosevelt Ave., Allbrook Mall Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $206 per night from Mar 27 to Mar 28
CA $206
CA $227 total
Mar 27 - Mar 28
includes taxes & fees
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (1,008 reviews)
Front staff were so helpful and friendly.

Reviewed on Mar 8, 2026

Opens in a new windowMarriott Panama Hotel
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
Fully refundableReserve now, pay when you stay
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (1,595 reviews)
El hotel es muy lindo y bien ubicado, lo único que no me gustó es que las cortinas no son muy oscuras y entra luz en la habitación, y que la pared del baño es de vidrio y con la luz se ve que estás en el inhodoro

Reviewed on Mar 9, 2026

Opens in a new windowDecapolis Hotel Panama City
American Trade Hotel

American Trade Hotel

4.5 out of 5
Plaza Herrera Casco Viejo Panama City Panama
The price is CA $346 per night from Apr 6 to Apr 7
CA $346
CA $382 total
Apr 6 - Apr 7
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (674 reviews)
The hotel is located in a pleasant area and is very conveniently within walking distance of several restaurants, bars, and shops. The staff were courteous and helpful. Since it is an older building, there are a few minor inconveniences in the bathroom—for example, the lighting could be better. I ...

Reviewed on Mar 9, 2026

Opens in a new windowAmerican Trade Hotel
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
The price is CA $149 per night from Apr 4 to Apr 5
CA $149
CA $164 total
Apr 4 - Apr 5
includes taxes & fees
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
9/10 Wonderful! (1,021 reviews)
Hotel is in a great location for partying ans shopping

Reviewed on Mar 9, 2026

Opens in a new windowCourtyard by Marriott Panama Multiplaza Mall
Studio Coliving

Studio Coliving

4.5 out of 5
Av. Ricardo Arango y, Av. Federico Boyd Panama City Panama
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff in ...
Opens in a new windowStudio Coliving
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Vía Tocumen Tocumen Panama
Fully refundableReserve now, pay when you stay
The price is CA $170 per night from Mar 18 to Mar 19
CA $170
CA $187 total
Mar 18 - Mar 19
includes taxes & fees
Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.4/10 Very Good! (1,873 reviews)
Clean room friendly staff at front desk, gift shop and restaurant. Room was lacking coffee maker and lighting was poor.

Reviewed on Mar 9, 2026

Opens in a new windowRiande Aeropuerto Hotel & Casino
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4 Star Hotels Panama City

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Panama City 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Panama City will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Panama City, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Panama City hotel reviews by fellow wanderers