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Featured Panama City 4 Star hotels

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
Fully refundable
The price is CA $151 per night from Nov 2 to Nov 3
CA $151
CA $166 total
Nov 2 - Nov 3
includes taxes & fees
Stay at this 4-star family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
8.4/10 Very Good! (2,242 reviews)
"always take a cab..easy and no wait"

Reviewed on Oct 13, 2025

Opens in a new windowCrowne Plaza Panama Airport by IHG
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is CA $188 per night from Nov 9 to Nov 10
CA $188
CA $207 total
Nov 9 - Nov 10
includes taxes & fees
Stay at this 4-star spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
8.4/10 Very Good! (965 reviews)
"Centrally located and friendly staff"

Reviewed on Oct 10, 2025

Opens in a new windowSheraton Grand Panama
Marriott Panama Hotel

Marriott Panama Hotel

4 out of 5
Roosevelt Ave., Allbrook Mall, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is CA $189 per night from Nov 7 to Nov 8
CA $189
CA $207 total
Nov 7 - Nov 8
includes taxes & fees
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (1,001 reviews)
"Helpfull staff"

Reviewed on Oct 3, 2025

Opens in a new windowMarriott Panama Hotel
Studio Coliving

Studio Coliving

4.5 out of 5
Av. Ricardo Arango y, Av. Federico Boyd, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is CA $62 per night from Oct 18 to Oct 19
CA $62
CA $68 total
Oct 18 - Oct 19
includes taxes & fees
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
7.8/10 Good! (526 reviews)
"they need to improve the housekeeping daily cleaning and update the elevators."

Reviewed on Oct 15, 2025

Opens in a new windowStudio Coliving
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Plaza de la Independencia Casco Viejo, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
9/10 Wonderful! (1,007 reviews)
"I like everything have a good service and the property installation have a good maintenance ."

Reviewed on Oct 13, 2025

Opens in a new windowCentral Hotel Panama Casco Viejo
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa, Panama City
Fully refundableReserve now, pay when you stay
The price is CA $181 per night from Nov 8 to Nov 9
CA $181
CA $199 total
Nov 8 - Nov 9
includes taxes & fees
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.4/10 Very Good! (1,132 reviews)
"Absolutely amazing property. 10/10 recommendations from me. Worth the stay."

Reviewed on Oct 15, 2025

Opens in a new windowMegapolis Hotel Panamá
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi, Panama City
Fully refundableReserve now, pay when you stay
The price is CA $128 per night from Oct 21 to Oct 22
CA $128
CA $162 total
Oct 21 - Oct 22
includes taxes & fees
Stay at this 4-star spa B&B in Panama City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Albrook Shopping Mall and Via Espana are located ...
9/10 Wonderful! (538 reviews)
"Amazing hotel. Very nice and spacious room and friendliness staff."

Reviewed on Oct 16, 2025

Opens in a new windowWaymore Hotel Spa & Casino
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is CA $116 per night from Oct 25 to Oct 26
CA $116
CA $128 total
Oct 25 - Oct 26
includes taxes & fees
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,351 reviews)
"Very nice Hotel"

Reviewed on Oct 11, 2025

Opens in a new windowDecapolis Hotel Panama City
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is CA $187 per night from Nov 7 to Nov 8
CA $187
CA $206 total
Nov 7 - Nov 8
includes taxes & fees
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,008 reviews)
"The service from the hotel staff was very friendly and helpful"

Reviewed on Oct 10, 2025

Opens in a new windowLas Americas Golden Tower Panama
Novotel Panama City

Novotel Panama City

4 out of 5
Calle Jose I. Fabrega y Thais de Pons, El Cangre, Bella Vista, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is CA $135 per night from Nov 2 to Nov 3
CA $135
CA $149 total
Nov 2 - Nov 3
includes taxes & fees
Stay at this 4-star family-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,024 reviews)
"A"

Reviewed on Oct 16, 2025

Opens in a new windowNovotel Panama City
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4 Star Hotels Panama City

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Panama City 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Panama City will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Panama City, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Panama City hotel reviews by fellow wanderers