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Featured Panama City 4 Star hotels

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
The price is CA $190 per night from Jun 30 to Jul 1
CA $190
CA $218 total
Jun 30 - Jul 1
includes taxes & fees
Book a stay at this family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
8.6/10 Excellent! (2,588 reviews)
"Nice hotel. Close to airport with convienent shutttle to and from airport. Great restaurant on property with great staff. Check in staff were extremely friendly and helpful."

Reviewed on Jun 9, 2026

Opens in a new windowCrowne Plaza Panama Airport by IHG
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $198 per night from Jun 14 to Jun 15
CA $198
CA $218 total
Jun 14 - Jun 15
includes taxes & fees
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the helpful staff in ...
9/10 Wonderful! (1,036 reviews)
"Loved how central this location is and amazing the staff is, always willing to help and happy to serve"

Reviewed on Jun 9, 2026

Opens in a new windowLas Americas Golden Tower Panama
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $158 per night from Jun 27 to Jun 28
CA $158
CA $174 total
Jun 27 - Jun 28
includes taxes & fees
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
9/10 Wonderful! (1,002 reviews)
"Localización"

Reviewed on Jun 9, 2026

Opens in a new windowCourtyard by Marriott Panama Multiplaza Mall
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

4 out of 5
Via Espana 111 Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $163 per night from Jun 29 to Jun 30
CA $163
CA $180 total
Jun 29 - Jun 30
includes taxes & fees
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
7.8/10 Good! (1,006 reviews)
"El gym súper malo viejo sin nada"

Reviewed on Jun 4, 2026

Opens in a new windowHotel El Panama by Faranda Grand, a member of Radisson Individuals
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Fully refundableReserve now, pay when you stay
The price is CA $140 per night from Jun 11 to Jun 12
CA $140
CA $207 total
Jun 11 - Jun 12
includes taxes & fees
Book a stay at this spa B&B in Panama City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Albrook Shopping Mall and Via Espana are located ...
9/10 Wonderful! (961 reviews)
"Very friendly staff and excellent customer service from registration to housekeeping staff, including those who greet you at the door."

Reviewed on Jun 8, 2026

Opens in a new windowWaymore Hotel Spa & Casino
MARINN PLACE Financial District

MARINN PLACE Financial District

4.5 out of 5
C. Aquilino de la Guardia Panama City Panamá Province
Fully refundableReserve now, pay when you stay
The price is CA $116 per night from Jun 28 to Jun 29
CA $116
CA $128 total
Jun 28 - Jun 29
includes taxes & fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Albrook Shopping Mall and Via Espana ...
9/10 Wonderful! (377 reviews)
"Well-maintained, good breakfast, helpful staff, good central location, free parking"

Reviewed on Jun 9, 2026

Opens in a new windowMARINN PLACE Financial District
Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

4 out of 5
Avenida Domingo Diaz via Tocumen San Miguelito Panama
Fully refundableReserve now, pay when you stay
The price is CA $146 per night from Jul 4 to Jul 5
CA $146
CA $161 total
Jul 4 - Jul 5
includes taxes & fees
Book a stay at this business-friendly hotel in San Miguelito. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
9/10 Wonderful! (1,012 reviews)
"Breakfast was not good"

Reviewed on Jun 9, 2026

Opens in a new windowCourtyard by Marriott Panama Metromall
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
Fully refundableReserve now, pay when you stay
The price is CA $176 per night from Jun 13 to Jun 14
CA $176
CA $193 total
Jun 13 - Jun 14
includes taxes & fees
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,236 reviews)
"Well located hotel, close to good restaurants walking distance. Very comfortable rooms, parking accesible and helpful staff. Great stay."

Reviewed on Jun 9, 2026

Opens in a new windowRamada Plaza by Wyndham Panama Punta Pacifica
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
The price is CA $187 per night from Jul 3 to Jul 4
CA $187
CA $206 total
Jul 3 - Jul 4
includes taxes & fees
Book a stay at this spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
8.6/10 Excellent! (1,001 reviews)
"Everything is great"

Reviewed on Jun 9, 2026

Opens in a new windowSheraton Grand Panama
Studio Coliving

Studio Coliving

4.5 out of 5
Av. Ricardo Arango y, Av. Federico Boyd Panama City Panama
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff in ...
7.8/10 Good! (590 reviews)
"Clean, reasonable pricing. Staff was excellent, very responsive. Highly reccomend staying here"

Reviewed on Mar 26, 2026

Opens in a new windowStudio Coliving
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4 Star Hotels Panama City

Looking to live it up on your vacation with a bit of luxury? Or maybe you’ve decided that your boss can afford to put you up at a place of your choice on your next business trip?

Come on, you deserve it!

The best part about staying in Panama City 4 star hotels is that you’ll often be close to all the local sights and attractions. Whether you’re visiting the area for the first time or you’re back in town for more fun, a 4 star hotel is going to put you right in the heart of all the action.

Plus, you can rest easy knowing that you’re being well taken care of during your visit. Instead of worrying about where to eat or what to see, your friendly hotel staff will be happy to help you get whatever you need.

The best four star hotels in Panama City will also frequently include access to high-quality fitness centers and pools, so you’ll feel like you’re staying in an exclusive resort rather than a hotel. You won’t have any excuse for not keeping up with your workout routine!

If you’re looking for 4 star hotels in Panama City, you’ll find the most bang for your buck by booking your stay with Travelocity. Go explore a new city, and know you’re getting the best deal on a great hotel with the Travelocity Price Guarantee.

Recent Panama City hotel reviews by fellow wanderers

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