Defiance Vacations 2026 from CA $999

Defiance flight + hotel packages

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

CA $999

per person

Jul 23 - Jul 27

found 1 day ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

Book a stay at this business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient parking in our reviews. Popular attractions Six Flags St. Louis and Skid Row are located nearby.

Hermann Grain Bins BNB

CA $1,989

per person

Jul 30 - Aug 4

found 21 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

Stay at this B&B in Hermann. Enjoy free breakfast, free parking, and a garden.

Tru By Hilton St. Louis Downtown

Downtown West

CA $1,088

per person

Jul 23 - Jul 27

found 1 day ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

Stay at this hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions St. Louis Union Station and Busch Stadium are located nearby.

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Grand Center

CA $1,078

per person

Jul 23 - Jul 27

found 1 day ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions St. Louis Union Station and Busch Stadium are located nearby.

The Cheshire

CA $1,231

per person

Jul 23 - Jul 27

found 1 day ago

Roundtrip non-stop flight included

Toronto (YYZ) to St. Louis (STL)

Book a stay at this boutique hotel in Richmond Heights. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions St. Louis Zoo and St. Louis Union Station are located nearby.

Top Defiance hotels deals

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive Maryland Heights MO

Free cancellation

Reserve now, pay when you stay

CA $133

CA $175 total

Jun 1 - Jun 2

includes taxes & fees

Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Hollywood Casino Amphitheatre and Ameristar Casino St. Charles are located nearby.

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

1088 South Highway Drive Fenton MO

Free cancellation

Reserve now, pay when you stay

CA $122

CA $141 total

May 17 - May 18

includes taxes & fees

Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Simpson Park and LIFECHURCH are located nearby.

The Wildwood Hotel

2801 Fountain Pl Wildwood MO

Free cancellation

Reserve now, pay when you stay

CA $117

CA $137 total

May 25 - May 26

includes taxes & fees

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

Free cancellation

Reserve now, pay when you stay

CA $218

CA $277 total

May 17 - May 18

includes taxes & fees

Book a stay at this luxury hotel in St. Charles. Enjoy a full-service spa, 6 restaurants, and a casino. Our guests praise the clean rooms in our reviews. Popular attractions Ameristar Casino St. Charles and Hollywood Casino Amphitheatre are located nearby.

La Quinta Inn & Suites by Wyndham St. Louis Westport

11805 Lackland Rd Maryland Heights MO

Free cancellation

Reserve now, pay when you stay

CA $132

CA $153 total

May 31 - Jun 1

includes taxes & fees

Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free WiFi, free parking, and a free airport shuttle. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Hollywood Casino Amphitheatre and Ameristar Casino St. Charles are located nearby.

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

13639 Riverport Dr Maryland Heights MO

Free cancellation

Reserve now, pay when you stay

CA $150

CA $174 total

May 25 - May 26

includes taxes & fees

Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Hollywood Casino Amphitheatre and Ameristar Casino St. Charles are located nearby.

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Defiance Vacations

Before you fly off to Defiance on a whim, take the time to learn a few facts about it.

Around 30 miles (48 kilometers) to the west of downtown St. Louis, Defiance is one of the neighborhoods that make this city so appealing.

At last count, the population of St. Louis was 320,000.

Places to visit in Defiance

The St. Louis region offers plenty of opportunities for outdoor adventures. Why not go rock climbing while you're here? If you'd like to double the fun factor, also make plans to go caving.

Where do you fly into for Defiance?

Fasten your seatbelt and get ready to touch down at Spirit of St. Louis Airport (SUS). This is the closest major terminal and it's approximately 9 miles (14 kilometers) to the east from the center of Defiance. Collect your luggage and let the fun begin!

Frequently asked questions

How much are vacation packages to Defiance?

Treat yourself to a one-of-a-kind experience in Defiance with a vacation package starting from just CA $999. Organizing your hotels, tours and flights with Travelocity is a piece of cake. What's more, our vacation deals will leave you with extra cash for loads of fun times.

Where can I get the best vacation package deals for Defiance?

It's difficult to beat Travelocity when it comes to piecing together your Defiance package deal. There are as many as 400 partner airlines and 1,000,000 properties around the world to choose from. Secure your trip now and get ready to cross another amazing place off your travel bucket list.

Why should I purchase my Defiance vacation package with Travelocity?

From our 24/7 customer care to our range of fantastic destinations, we're committed to fulfilling your travel desires. All you'll have to do is click and book — our Price Match Guarantee will make sure you score the best price.

Can I save on my Defiance car rental if I bundle it with my hotel or flight?

With a Defiance vacation package, you can bundle your hotel, car and flight bookings and save some serious money. If you'd love to discover the best of this wonderful part of the world, why not head to Busch Stadium? This popular attraction is 48 kilometers from Defiance. With your own rental car, you'll be there before you know it.

Which airport is best for Defiance?

Lambert-St. Louis Intl. Airport (STL) is the top airport for those flying to Defiance. Once you touch down, you'll find yourself 40 kilometers east of the downtown area.

What is there to do in Defiance?

There is a certain magic in the air as you stroll the streets of Defiance. Chandler Hill Vineyards and Historic Daniel Boone Home and Heritage Center are just two famous sights that make this city so popular, so put them at the top of your must-see list.

Where should I stay when visiting Defiance?

The BACKYARD OASIS! Cozy and charming 60s Brick ranch with relaxing gazebo over pond is recommended by many travelers. Book soon to avoid missing out.