Defiance Vacations 2026

Top Defiance hotels deals

Sonesta ES Suites St. Louis - Chesterfield

15431 Conway Rd Chesterfield MO

Free cancellation

Reserve now, pay when you stay

CA $131

CA $152 total

Nov 12 - Nov 13

includes taxes & fees

Stay at this hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Sophia M. Sachs Butterfly House and The Awakening Sculpture are located nearby.

Pool

Breakfast included

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive Maryland Heights MO

Free cancellation

Reserve now, pay when you stay

CA $98

CA $135 total

Dec 6 - Dec 7

includes taxes & fees

Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Hollywood Casino Amphitheatre and Ameristar Casino St. Charles are located nearby.

Free airport shuttle

Parking included

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

Free cancellation

Reserve now, pay when you stay

CA $226

CA $288 total

Nov 16 - Nov 17

includes taxes & fees

Book a stay at this luxury hotel in St. Charles. Enjoy a full-service spa, 6 restaurants, and a casino. Our guests praise the clean rooms in our reviews. Popular attractions Ameristar Casino St. Charles and Hollywood Casino Amphitheatre are located nearby.

Pool

Hot tub

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

13639 Riverport Dr Maryland Heights MO

Free cancellation

Reserve now, pay when you stay

CA $107

CA $126 total

Dec 1 - Dec 2

includes taxes & fees

Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Hollywood Casino Amphitheatre and Ameristar Casino St. Charles are located nearby.

Pool

Breakfast included

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

1088 South Highway Drive Fenton MO

Free cancellation

Reserve now, pay when you stay

CA $126

CA $146 total

Nov 12 - Nov 13

includes taxes & fees

Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions LIFECHURCH and Bowlero Lakeside are located nearby.

Pool

Hot tub

The Wildwood Hotel

2801 Fountain Pl Wildwood MO

Free cancellation

Reserve now, pay when you stay

CA $113

CA $132 total

Dec 8 - Dec 9

includes taxes & fees

Book a stay at this business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient parking in our reviews. Popular attractions Six Flags St. Louis and Skid Row are located nearby.

Pool

Hot tub

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Defiance attractions

Chandler Hill Vineyards

7.8/10 (7 reviews)

You can enjoy a tasting or tour at Chandler Hill Vineyards during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants.

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Defiance Vacations

Before you fly off to Defiance on a whim, take the time to learn a few facts about it.

Around 30 miles (48 kilometers) to the west of downtown St. Louis, Defiance is one of the neighborhoods that make this city so appealing.

At last count, the population of St. Louis was 320,000.

Places to visit in Defiance

The St. Louis region offers plenty of opportunities for outdoor adventures. Why not go rock climbing while you're here? If you'd like to double the fun factor, also make plans to go caving.

Where do you fly into for Defiance?

Fasten your seatbelt and get ready to touch down at Spirit of St. Louis Airport (SUS). This is the closest major terminal and it's approximately 9 miles (14 kilometers) to the east from the center of Defiance. Collect your luggage and let the fun begin!

Frequently asked questions

How much are vacation packages to Defiance?

Treat yourself to a one-of-a-kind experience in Defiance with a vacation package starting from just . Organizing your hotels, tours and flights with Travelocity is a piece of cake. What's more, our vacation deals will leave you with extra cash for loads of fun times.

Where can I get the best vacation package deals for Defiance?

It's difficult to beat Travelocity when it comes to piecing together your Defiance package deal. There are as many as 400 partner airlines and 1,000,000 properties around the world to choose from. Secure your trip now and get ready to cross another amazing place off your travel bucket list.

Why should I purchase my Defiance vacation package with Travelocity?

From our 24/7 customer care to our range of fantastic destinations, we're committed to fulfilling your travel desires. All you'll have to do is click and book — our Price Match Guarantee will make sure you score the best price.

Can I save on my Defiance car rental if I bundle it with my hotel or flight?

With a Defiance vacation package, you can bundle your hotel, car and flight bookings and save some serious money. If you'd love to discover the best of this wonderful part of the world, why not head to Busch Stadium? This popular attraction is 48 kilometers from Defiance. With your own rental car, you'll be there before you know it.

Which airport is best for Defiance?

Lambert-St. Louis Intl. Airport (STL) is the top airport for those flying to Defiance. Once you touch down, you'll find yourself 40 kilometers east of the downtown area.

What is there to do in Defiance?

There is a certain magic in the air as you stroll the streets of Defiance. Chandler Hill Vineyards and Historic Daniel Boone Home and Heritage Center are just two famous sights that make this city so popular, so put them at the top of your must-see list.

Where should I stay when visiting Defiance?

The BACKYARD OASIS! Cozy and charming 60s Brick ranch with relaxing gazebo over pond is recommended by many travelers. Book soon to avoid missing out.