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Hotels near South Central Houston

Wanderstay Boutique Hotel
520 Sampson St, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this hotel in Houston. Enjoy free WiFi, free parking, and daily housekeeping. Popular attractions Daikin Park and Toyota Center are located nearby.
Great location will stay again
Reviewed on Nov 3, 2025

InterContinental Houston by IHG
6750 Main St, Houston, TX
Fully refundable
The price is CA $195 per night from Nov 28 to Nov 29
CA $195
CA $256 total
Nov 28 - Nov 29
includes taxes & fees
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
Nice
Reviewed on Nov 11, 2025

The Westin Houston Medical Center/Museum District
1709 DRYDEN ROAD, Houston, TX
Fully refundableReserve now, pay when you stay
The price is CA $192 per night from Nov 29 to Nov 30
CA $192
CA $239 total
Nov 29 - Nov 30
includes taxes & fees
Stay at this 4-star business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ...
Everything about my stay was great and everything went smoothly. Valet was efficient and careful, check-in was easy and the concierge kindly granted my request for a quiet room away from traffic and noise. Room was clean, so nice, and EVERYTHING WORKED (a rarity these days). Terrace 54 Restaurant ...
Reviewed on Nov 10, 2025

Houston Marriott Medical Center/Museum District
6580 Fannin Street, Houston, TX
Fully refundableReserve now, pay when you stay
The price is CA $201 per night from Nov 29 to Nov 30
CA $201
CA $279 total
Nov 29 - Nov 30
includes taxes & fees
Stay at this 4-star business-friendly hotel in Houston. Enjoy breakfast (surcharge), a free area shuttle, and room service. Our guests praise the helpful staff ...
Comfortable bed, very clean, very good food, quite, friendly stuff and hotel shuttle works easy.
Reviewed on Nov 6, 2025

Mint House Houston – Medical Center
1911 Holcombe Boulevard, Houston, TX
Stay at this 4-star apartment in Houston. Enjoy free WiFi, a rooftop terrace, and a 24-hour fitness center. Popular attractions Houston Zoo and NRG Stadium are ...
Except for the carpet in the bedroom, the rooms were spotless. Great views. Convenient to MD Anderson and the rest of the Texas Medical Center.
Reviewed on Nov 5, 2025

Hotel Zaza Houston Museum District
5701 Main Street, Houston, TX
Fully refundableReserve now, pay when you stay
The price is CA $280 per night from Nov 26 to Nov 27
CA $280
CA $385 total
Nov 26 - Nov 27
includes taxes & fees
Stay at this 4.5-star luxury aparthotel in Houston. Enjoy free WiFi, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff and the property ...
The room was spotless, service was amazing, the food was delicious!
Reviewed on Nov 5, 2025

Hilton Houston Plaza/Medical Center
6633 Travis St, Houston, TX
Fully refundableReserve now, pay when you stay
The price is CA $124 per night from Nov 30 to Dec 1
CA $124
CA $147 total
Nov 30 - Dec 1
includes taxes & fees
Stay at this 4.5-star luxury hotel in Houston. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in ...
Thr ac was a bit loud. Otherwise perfection as usual!
Reviewed on Nov 11, 2025

DoubleTree by Hilton Houston Medical Center Hotel & Suites
6800 Main Street, Houston, TX
Fully refundableReserve now, pay when you stay
The price is CA $150 per night from Nov 27 to Nov 28
CA $150
CA $176 total
Nov 27 - Nov 28
includes taxes & fees
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
Great service
Reviewed on Oct 26, 2025

Downtowner Inns - Houston Downtown
2510 Hamilton St, Houston, TX
Fully refundableReserve now, pay when you stay
The price is CA $133 per night from Nov 13 to Nov 14
CA $133
CA $156 total
Nov 13 - Nov 14
includes taxes & fees
Stay at this hotel in Houston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Toyota Center and Daikin Park are located nearby.
Everything was perfect!
Reviewed on Nov 1, 2025
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Recent South Central Houston hotel reviews by fellow wanderers

InterContinental Houston by IHG
5 out of 5
Posted 12 hours ago
Travelocity Verified Review
"Nice"
A verified traveller from Athens stayed at InterContinental Houston by IHG
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