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Hotels near Medical Center District
Drury Plaza Hotel San Antonio Riverwalk
105 S Saint Marys Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $167 per night from Feb 8 to Feb 9
CA $167
CA $197 total
Feb 8 - Feb 9
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...
Staff was very courteous. Room was very quiet and clean. Very good breakfast.
Reviewed on Jan 14, 2026
Hotel Valencia Riverwalk
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the ...
Great hotel! Very nice style of the hall, nice rooms. Very nice coffee shop! Great location! They have a resort fee which could be used for breakfast-dinner in their restaurant (we were not told about it at check-in, it was the only minus in the whole stay, but they still make it up to us at check ...
Reviewed on Jan 14, 2026
Thompson San Antonio - Riverwalk, by Hyatt
115 Lexington Avenue San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $247 per night from Feb 1 to Feb 2
CA $247
CA $340 total
Feb 1 - Feb 2
includes taxes & fees
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the bar and the helpful staff ...
Excellent check in and out.
Reviewed on Jan 4, 2026
Menger Hotel
204 Alamo Plaza San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $173 per night from Jan 26 to Jan 27
CA $173
CA $204 total
Jan 26 - Jan 27
includes taxes & fees
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our reviews. ...
Our stay at the Menger Hotel was truly lovely! The adornment throughout is beautiful, the service prompt and thorough, and the easy access to the riverwalk and surrounding area was very convenient! We especially loved the servers at breakfast, so personable and kind. I recommend this place 100%!
Reviewed on Jan 12, 2026
Hyatt Vacation Club at Wild Oak Ranch, San Antonio
9700 West Military Drive San Antonio TX
Fully refundable
The price is CA $105 per night from Feb 1 to Feb 2
CA $105
CA $182 total
Feb 1 - Feb 2
includes taxes & fees
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the helpful staff in ...
Everything was amazing with the exception of the pillows. They didn't offer any support and were uncomfortable. Would suggest more supportive pillows.
Reviewed on Jan 16, 2026
San Antonio Marriott Northwest Medical Center
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $141 per night from Jan 23 to Jan 24
CA $141
CA $167 total
Jan 23 - Jan 24
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy a free area shuttle, room service, and a 24-hour fitness center. Our guests praise the helpful ...
Nice stay
Reviewed on Jan 13, 2026
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $124 per night from Jan 19 to Jan 20
CA $124
CA $146 total
Jan 19 - Jan 20
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
OK
Reviewed on Jan 14, 2026
Riverwalk Plaza
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $152 per night from Jan 25 to Jan 26
CA $152
CA $179 total
Jan 25 - Jan 26
includes taxes & fees
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
Great stay. Older hotel but service was good. Hotel was clean.
Reviewed on Jan 12, 2026
Park Inn by Radisson
7500 Louis Pasteur Drive San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $93 per night from Jan 20 to Jan 21
CA $93
CA $108 total
Jan 20 - Jan 21
includes taxes & fees
Stay at this motel in San Antonio. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
Clean room and easy check in
Reviewed on Jan 15, 2026
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Recent Medical Center District hotel reviews by fellow wanderers
Hyatt Vacation Club at Wild Oak Ranch, San Antonio
5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Everything was amazing with the exception of the pillows. They didn't offer any support and were uncomfortable. Would suggest more supportive pillows. "
A verified traveller stayed at Hyatt Vacation Club at Wild Oak Ranch, San Antonio
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