Find a cheap Hotel in Medical Center District

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Area
Area
Popular locations
Popular locations
Meal plans available
Meal plans available
Property amenities
Property amenities
Accessibility
Accessibility
Traveller experience
Traveller experience

Hotels near Medical Center District

Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

4 out of 5
105 S Saint Marys Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $182 per night from Jul 2 to Jul 3
CA $182
CA $215 total
Jul 2 - Jul 3
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...
"The free breakfast and happy hour dinner was great"

Reviewed on Jun 28, 2026

Opens in a new windowDrury Plaza Hotel San Antonio Riverwalk
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $168 per night from Jul 11 to Jul 12
CA $168
CA $239 total
Jul 11 - Jul 12
includes taxes & fees
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean ...
"This was a great hotel with a lot of charm and character."

Reviewed on Jun 27, 2026

Opens in a new windowHotel Valencia Riverwalk
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $128 per night from Jul 5 to Jul 6
CA $128
CA $151 total
Jul 5 - Jul 6
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
"Great staff even the managers were helping clean and pick up during breakfast and dinner."

Reviewed on Jun 27, 2026

Opens in a new windowDrury Inn & Suites San Antonio Northwest Medical Center
Crockett Hotel

Crockett Hotel

3 out of 5
320 Bonham San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $148 per night from Jun 29 to Jun 30
CA $148
CA $175 total
Jun 29 - Jun 30
includes taxes & fees
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Our guests praise the pool and the restaurant ...
"Watch out for the add on fee for parking that they don’t tell you about. It cost me $60"

Reviewed on Jun 27, 2026

Opens in a new windowCrockett Hotel
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $152 per night from Jul 12 to Jul 13
CA $152
CA $181 total
Jul 12 - Jul 13
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy room service, a 24-hour fitness center, and WiFi (surcharge). Our guests praise the helpful ...
"I urge any future traveler to skip this hotel. I called the hotel to make sure they had a crib for newborn, which they confirmed and so I proceeded with the reservation. When we arrived, at almost midnight, the front desk guy checked us in, and then said that they didn’t have any cribs and all they ..."

Reviewed on Jun 25, 2026

Opens in a new windowSan Antonio Marriott Northwest Medical Center
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $126 per night from Jul 5 to Jul 6
CA $126
CA $149 total
Jul 5 - Jul 6
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
"Provides bare neccesities. Had to pay extra $11 for parking which wasn’t disclosed. Lastly, everyday i had to go back to the front desk to get my key reprogrammed. Smh."

Reviewed on Jun 28, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

3 out of 5
303 Blum Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $101 per night from Jul 5 to Jul 6
CA $101
CA $147 total
Jul 5 - Jul 6
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, a fitness center, and parking (surcharge). Our guests praise the breakfast ...
"Very nice hotel, clean and the breakfast was great. Highly recommend"

Reviewed on Jun 27, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $126 per night from Jul 5 to Jul 6
CA $126
CA $150 total
Jul 5 - Jul 6
includes taxes & fees
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
"Staff was very friendly and helpful"

Reviewed on Jun 28, 2026

Opens in a new windowRiverwalk Plaza
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $126 per night from Jul 10 to Jul 11
CA $126
CA $149 total
Jul 10 - Jul 11
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
Opens in a new windowCourtyard by Marriott Medical Center San Antonio
Don't see what you're looking for?
See all available properties in Medical Center District
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Medical Center District Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Medical Center District area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Medical Center District to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Medical Center District are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Medical Center District hotel reviews by fellow wanderers

Explore More Ways to Travel with Travelocity