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Hotels near Medical Center District
Hotel Valencia Riverwalk
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $207 per night from Mar 22 to Mar 23
CA $207
CA $284 total
Mar 22 - Mar 23
includes taxes & fees
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the ...
Beautiful location overlooking the river walk.
Reviewed on Mar 18, 2026
Drury Plaza Hotel San Antonio Riverwalk
105 S Saint Marys Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $175 per night from Apr 1 to Apr 2
CA $175
CA $207 total
Apr 1 - Apr 2
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...
Our Stay was absolutely amazing. The staff was very helpful and attention. Rooms were very clean and comfortable. Food and drinks were very good. Awesome stay.
Reviewed on Mar 18, 2026
Hyatt Regency San Antonio Riverwalk
123 Losoya St San Antonio TX
The price is CA $245 per night from Apr 5 to Apr 6
CA $245
CA $340 total
Apr 5 - Apr 6
includes taxes & fees
Book a stay at this spa hotel in San Antonio. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the clean rooms ...
Very clean and super convenient
Reviewed on Mar 18, 2026
Hyatt Vacation Club at Wild Oak Ranch, San Antonio
9700 West Military Drive San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $151 per night from Apr 13 to Apr 14
CA $151
CA $235 total
Apr 13 - Apr 14
includes taxes & fees
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the helpful staff in ...
This is my third time staying here and I have definitely noticed a few things have changed and not for the better. Just seemed to me the customer has to suffer with minimal housekeeping and not the customer service there was before.
Reviewed on Mar 18, 2026
Menger Hotel
204 Alamo Plaza San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $149 per night from Apr 1 to Apr 2
CA $149
CA $176 total
Apr 1 - Apr 2
includes taxes & fees
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our reviews. ...
Beautiful historic hotel filled with antique furniture light fixtures and artwork. Limited staffing. Restaurant closed two days in a row. Elevator floor was never cleaned during stay. Bathroom amenities missing. Jacuzzi tub jets and filter were filthy. Limited to no maid service available during ...
Reviewed on Mar 18, 2026
San Antonio Marriott Northwest Medical Center
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $139 per night from Mar 28 to Mar 29
CA $139
CA $165 total
Mar 28 - Mar 29
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy a free area shuttle, room service, and a 24-hour fitness center. Our guests praise the helpful ...
Everything was good
Reviewed on Mar 18, 2026
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $122 per night from Mar 22 to Mar 23
CA $122
CA $144 total
Mar 22 - Mar 23
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Great staff. Clean room. Ice machines not working on at least two floors though.
Reviewed on Mar 18, 2026
Riverwalk Plaza
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
Numerous unsupervised teenagers sprinting through the hallways and making lots of noise as late as two in the morning on a Thursday night. Staff were aware of the issue yet it persisted.
Reviewed on Mar 18, 2026
Park Inn by Radisson
7500 Louis Pasteur Drive San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $88 per night from Apr 6 to Apr 7
CA $88
CA $102 total
Apr 6 - Apr 7
includes taxes & fees
Stay at this motel in San Antonio. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
Nothing out of the ordinary but in a good way.
Reviewed on Feb 28, 2026
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Recent Medical Center District hotel reviews by fellow wanderers
Omni La Mansion del Rio
5 out of 5
Posted 3 hours ago
Travelocity Verified Review
"Beautiful hotel with direct access to the River Walk. Super friendly staff who made our honeymoon extra special. Will definitely stay here again. "
A verified traveller stayed at Omni La Mansion del Rio
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