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Hotels near Medical Center District
Drury Plaza Hotel San Antonio Riverwalk
105 S Saint Marys Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $167 per night from Jan 16 to Jan 17
CA $167
CA $197 total
Jan 16 - Jan 17
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...
Yes
Reviewed on Jan 7, 2026
Hotel Valencia Riverwalk
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $458 per night from Jan 17 to Jan 18
CA $458
CA $574 total
Jan 17 - Jan 18
includes taxes & fees
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the ...
Cool
Reviewed on Jan 8, 2026
Hyatt Vacation Club at Wild Oak Ranch, San Antonio
9700 West Military Drive San Antonio TX
Fully refundable
The price is CA $99 per night from Jan 26 to Jan 27
CA $99
CA $175 total
Jan 26 - Jan 27
includes taxes & fees
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the helpful staff in ...
The stay was great, 1 bdrm suite was perfect, friendly staff, an overall great experience. Will be going back in the future!
Reviewed on Jan 10, 2026
Menger Hotel
204 Alamo Plaza San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $206 per night from Jan 17 to Jan 18
CA $206
CA $243 total
Jan 17 - Jan 18
includes taxes & fees
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our reviews. ...
The room was very clean and spotless in fact the entire hotel was beautiful. Such great history
Reviewed on Jan 8, 2026
San Antonio Marriott Northwest Medical Center
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $153 per night from Jan 16 to Jan 17
CA $153
CA $181 total
Jan 16 - Jan 17
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy a free area shuttle, room service, and a 24-hour fitness center. Our guests praise the helpful ...
Great hotel and amenities, clean, nice bar area and attentive staff.
Reviewed on Jan 8, 2026
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $124 per night from Jan 12 to Jan 13
CA $124
CA $146 total
Jan 12 - Jan 13
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Great breakfast and very clean
Reviewed on Jan 7, 2026
Sonesta ES Suites San Antonio Downtown Alamo Plaza
425 Bonham San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $119 per night from Jan 18 to Jan 19
CA $119
CA $141 total
Jan 18 - Jan 19
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
The breakfast wasn't included In the stay even if we payed top dollar for the room bummer we were starving
Reviewed on Jan 7, 2026
Riverwalk Plaza
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
It was cozy and made me feel at home! Absolutely loved my stay and Definitely will stay here again.
Reviewed on Jan 8, 2026
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
303 Blum Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $99 per night from Feb 8 to Feb 9
CA $99
CA $142 total
Feb 8 - Feb 9
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
It was great
Reviewed on Jan 9, 2026
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Recent Medical Center District hotel reviews by fellow wanderers
Hyatt Vacation Club at Wild Oak Ranch, San Antonio
5 out of 5
Posted 18 hours ago
Travelocity Verified Review
"The stay was great, 1 bdrm suite was perfect, friendly staff, an overall great experience. Will be going back in the future!"
A verified traveller stayed at Hyatt Vacation Club at Wild Oak Ranch, San Antonio
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