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Hotels near Medical Center District

Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

3 out of 5
105 S Saint Marys Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $165 per night from Jan 11 to Jan 12
CA $165
CA $195 total
Jan 11 - Jan 12
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...
Very friendly staff. Great Riverwaklk location.

Reviewed on Jan 2, 2026

Opens in a new windowDrury Plaza Hotel San Antonio Riverwalk
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the ...
Amazing hotel

Reviewed on Jan 2, 2026

Opens in a new windowHotel Valencia Riverwalk
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
9700 West Military Drive San Antonio TX
Fully refundable
The price is CA $98 per night from Feb 2 to Feb 3
CA $98
CA $172 total
Feb 2 - Feb 3
includes taxes & fees
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the helpful staff in ...
Great amenities and friendly staff.

Reviewed on Dec 30, 2025

Opens in a new windowHyatt Vacation Club at Wild Oak Ranch, San Antonio
Menger Hotel

Menger Hotel

3.5 out of 5
204 Alamo Plaza San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $137 per night from Jan 14 to Jan 15
CA $137
CA $162 total
Jan 14 - Jan 15
includes taxes & fees
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our reviews. ...
Beautiful Hotel and close to everything downtown and Riverwalk

Reviewed on Jan 2, 2026

Opens in a new windowMenger Hotel
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $151 per night from Jan 16 to Jan 17
CA $151
CA $179 total
Jan 16 - Jan 17
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy a free area shuttle, room service, and a 24-hour fitness center. Our guests praise the helpful ...
Comfy clean

Reviewed on Dec 28, 2025

Opens in a new windowSan Antonio Marriott Northwest Medical Center
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $122 per night from Jan 4 to Jan 5
CA $122
CA $144 total
Jan 4 - Jan 5
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Clean room and nice staff

Reviewed on Jan 1, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Sonesta ES Suites San Antonio Downtown Alamo Plaza

Sonesta ES Suites San Antonio Downtown Alamo Plaza

3 out of 5
425 Bonham San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $117 per night from Jan 7 to Jan 8
CA $117
CA $139 total
Jan 7 - Jan 8
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
Location was great. Room was great. No sure why when you book two rooms they made them as far apart as they could. At least the rooms were on same floor. Breakfast wasn't anything to write about. I was expecting more. Parking was a little on the pricey side at $50 a night which is more than i use ...

Reviewed on Jan 2, 2026

Opens in a new windowSonesta ES Suites San Antonio Downtown Alamo Plaza
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
Confortable and well located.

Reviewed on Jan 2, 2026

Opens in a new windowRiverwalk Plaza
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

3 out of 5
303 Blum Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $98 per night from Jan 6 to Jan 7
CA $98
CA $139 total
Jan 6 - Jan 7
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Everything was fine except at breakfast, it was soo crowded every morning. People took super loaded plates to rooms leaving a mess but still no place to sit. Very noisy, not just at breakfast, at night street sound from traffic was awful but I know that’s not hotels fault. Location is close to every ...

Reviewed on Dec 28, 2025

Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Riverwalk
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Medical Center District Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Medical Center District area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Medical Center District to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Medical Center District are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Medical Center District hotel reviews by fellow wanderers