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Hotels near Medical Center District

Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

4 out of 5
105 S Saint Marys Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $179 per night from Jun 21 to Jun 22
CA $179
CA $211 total
Jun 21 - Jun 22
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...
"Beautiful hotel excellent location"

Reviewed on Jun 13, 2026

Opens in a new windowDrury Plaza Hotel San Antonio Riverwalk
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $197 per night from Jul 12 to Jul 13
CA $197
CA $273 total
Jul 12 - Jul 13
includes taxes & fees
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean ...
"Housekeeping didn't service the room everyday. Roof leak due to rain and humid hallways could be improved upon. Doorman/Valets were exceptional."

Reviewed on Jun 13, 2026

Opens in a new windowHotel Valencia Riverwalk
Omni La Mansion del Rio

Omni La Mansion del Rio

4 out of 5
112 College St San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $233 per night from Jun 21 to Jun 22
CA $233
CA $280 total
Jun 21 - Jun 22
includes taxes & fees
Book a stay at this spa hotel in San Antonio. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff in ...
"Wonderful staff and amenities! The steak house was amazing and the access to the river walk is wonderful! The pool was great and the drinks and snacks are great! Centrally located to have all you need within walking distance."

Reviewed on Jun 12, 2026

Opens in a new windowOmni La Mansion del Rio
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $126 per night from Jun 21 to Jun 22
CA $126
CA $149 total
Jun 21 - Jun 22
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
"We knew staying at a Drury Hotel we would have a great stay. Previous stay at Riverwalk area was beyond our expectations. I will always recommend this hotel."

Reviewed on Jun 13, 2026

Opens in a new windowDrury Inn & Suites San Antonio Northwest Medical Center
Hotel Contessa

Hotel Contessa

4 out of 5
306 W Market Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $178 per night from Jul 14 to Jul 15
CA $178
CA $249 total
Jul 14 - Jul 15
includes taxes & fees
Book a stay at this spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
"The interior of the rooms are unique, and housekeeping staff are very nice. We had breakfast at the restraunt and staff made the experience pleasant. Location is convenient to experience downtown area."

Reviewed on Jun 13, 2026

Opens in a new windowHotel Contessa
Menger Hotel

Menger Hotel

3.5 out of 5
204 Alamo Plaza San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $143 per night from Jul 12 to Jul 13
CA $143
CA $169 total
Jul 12 - Jul 13
includes taxes & fees
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our reviews. ...
"Beautiful place"

Reviewed on Jun 13, 2026

Opens in a new windowMenger Hotel
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $141 per night from Jul 10 to Jul 11
CA $141
CA $168 total
Jul 10 - Jul 11
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy a free area shuttle, room service, and a 24-hour fitness center. Our guests praise the helpful ...
"The Marriot from check in to check out was top notch. Ricky checked me in and was by far the most pleasant, helpful, and accommodating of any concierge I’ve ever encountered. Great stay!"

Reviewed on Jun 8, 2026

Opens in a new windowSan Antonio Marriott Northwest Medical Center
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $124 per night from Jun 15 to Jun 16
CA $124
CA $147 total
Jun 15 - Jun 16
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
"Good hotel. Nice ppl there."

Reviewed on Jun 13, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $125 per night from Jun 21 to Jun 22
CA $125
CA $147 total
Jun 21 - Jun 22
includes taxes & fees
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
"Everyone extremely friendly and helpful"

Reviewed on Jun 13, 2026

Opens in a new windowRiverwalk Plaza
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Medical Center District Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Medical Center District area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Medical Center District to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Medical Center District are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Medical Center District hotel reviews by fellow wanderers

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