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Hotels near Medical Center District
Drury Plaza Hotel San Antonio Riverwalk
105 S Saint Marys Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $176 per night from Sep 21 to Sep 22
CA $176
CA $209 total
Sep 21 - Sep 22
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...
"I loved this hotel from the friendly employees to the great cozy atmosphere Thank you I will definitely recommend"
Reviewed on Aug 21, 2026
San Antonio Marriott Northwest Medical Center
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $151 per night from Sep 18 to Sep 19
CA $151
CA $180 total
Sep 18 - Sep 19
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy room service, a 24-hour fitness center, and WiFi (surcharge). Our guests praise the helpful ...
"Please don’t expect any help or flexibility from this Hotel. I notified them within 24 hours regarding my cancellation and they wouldn’t cooperate. Unlike any other hotel chain, they would want you to pay in advance. I visit the area a lot for business and I’ll never stay in that property."
Reviewed on Aug 19, 2026
Riverwalk Plaza
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $123 per night from Aug 23 to Aug 24
CA $123
CA $145 total
Aug 23 - Aug 24
includes taxes & fees
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
"We Brooke de this hotel last minute, it was a really great stay it was clean and well maintianed despite the age of the building. Staff were súper friendly. The bar and dinner were really convenient since they were Connected to the hotel. The location is perfect since its right on the River ..."
Reviewed on Aug 20, 2026
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $122 per night from Aug 24 to Aug 25
CA $122
CA $145 total
Aug 24 - Aug 25
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Courtyard by Marriott Medical Center San Antonio
8585 Marriott Dr San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $123 per night from Aug 28 to Aug 29
CA $123
CA $145 total
Aug 28 - Aug 29
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
Drury Inn & Suites San Antonio Northwest Medical Center
9806 Interstate Hwy 10 W San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $124 per night from Aug 26 to Aug 27
CA $124
CA $147 total
Aug 26 - Aug 27
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
303 Blum Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $98 per night from Sep 7 to Sep 8
CA $98
CA $143 total
Sep 7 - Sep 8
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, a fitness center, and parking (surcharge). Our guests praise the breakfast ...
Hotel Valencia Riverwalk
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $155 per night from Aug 29 to Aug 30
CA $155
CA $223 total
Aug 29 - Aug 30
includes taxes & fees
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean ...
Hyatt Regency San Antonio Riverwalk
123 Losoya St San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $210 per night from Aug 30 to Aug 31
CA $210
CA $293 total
Aug 30 - Aug 31
includes taxes & fees
Book a stay at this spa hotel in San Antonio. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the clean rooms ...
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Recent Medical Center District hotel reviews by fellow wanderers
Drury Plaza Hotel San Antonio Riverwalk
5 out of 5
Posted 7 hours ago
Travelocity Verified Review
"I loved this hotel from the friendly employees to the great cozy atmosphere Thank you I will definitely recommend"
A verified traveller stayed at Drury Plaza Hotel San Antonio Riverwalk
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