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Hotels near Medical Center District

Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

4 out of 5
105 S Saint Marys Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $181 per night from Nov 15 to Nov 16
CA $181
CA $216 total
Nov 15 - Nov 16
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...
"Everything is perfect"

Reviewed on Nov 8, 2026

Opens in a new windowDrury Plaza Hotel San Antonio Riverwalk
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $132 per night from Dec 8 to Dec 9
CA $132
CA $158 total
Dec 8 - Dec 9
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy room service, a 24-hour fitness center, and WiFi (surcharge). Our guests praise the helpful ...
"The staff was helpful and friendly. The fitness center was outdated and poor. Parking was difficult and dining did not have many options for food allergies."

Reviewed on Nov 8, 2026

Opens in a new windowSan Antonio Marriott Northwest Medical Center
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $125 per night from Nov 9 to Nov 10
CA $125
CA $150 total
Nov 9 - Nov 10
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
"Nice size room, clean. The property needs a fresh coat of paint around the doors, carpet can be upgraded. Good stay, friendly and helpful staff!"

Reviewed on Nov 7, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $126 per night from Nov 15 to Nov 16
CA $126
CA $150 total
Nov 15 - Nov 16
includes taxes & fees
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
"Friendly staff, comfortable room, close to downtown riverwalk."

Reviewed on Nov 7, 2026

Opens in a new windowRiverwalk Plaza
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $127 per night from Nov 12 to Nov 13
CA $127
CA $152 total
Nov 12 - Nov 13
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Opens in a new windowDrury Inn & Suites San Antonio Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $126 per night from Nov 26 to Nov 27
CA $126
CA $150 total
Nov 26 - Nov 27
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
Opens in a new windowCourtyard by Marriott Medical Center San Antonio
Hotel Valencia Riverwalk, Valencia Collection

Hotel Valencia Riverwalk, Valencia Collection

4.5 out of 5
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $159 per night from Nov 15 to Nov 16
CA $159
CA $230 total
Nov 15 - Nov 16
includes taxes & fees
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean ...
Opens in a new windowHotel Valencia Riverwalk, Valencia Collection
Crockett Hotel

Crockett Hotel

3 out of 5
320 Bonham San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $106 per night from Nov 22 to Nov 23
CA $106
CA $127 total
Nov 22 - Nov 23
includes taxes & fees
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Our guests praise the pool and the restaurant ...
Opens in a new windowCrockett Hotel
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

3 out of 5
303 Blum Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $109 per night from Nov 15 to Nov 16
CA $109
CA $159 total
Nov 15 - Nov 16
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Riverwalk
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Medical Center District Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Medical Center District area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Medical Center District to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Medical Center District are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Medical Center District hotel reviews by fellow wanderers

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