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Hotels near Medical Center District

Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the ...
Beautiful room. However, the toilet had issues, no mini fridge or microwave in the room. For this nice of a hotel you would expect those amenities. Also wish there was elevator access from the river up to the lobby of the hotel to make it safer for guests. The best part of the hotel was the valet ...

Reviewed on Feb 8, 2026

Opens in a new windowHotel Valencia Riverwalk
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
9700 West Military Drive San Antonio TX
Fully refundable
The price is CA $103 per night from Mar 1 to Mar 2
CA $103
CA $179 total
Mar 1 - Mar 2
includes taxes & fees
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the helpful staff in ...
Everything was spotless

Reviewed on Feb 3, 2026

Opens in a new windowHyatt Vacation Club at Wild Oak Ranch, San Antonio
Menger Hotel

Menger Hotel

3.5 out of 5
204 Alamo Plaza San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $119 per night from Feb 23 to Feb 24
CA $119
CA $141 total
Feb 23 - Feb 24
includes taxes & fees
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our reviews. ...
Staff

Reviewed on Feb 6, 2026

Opens in a new windowMenger Hotel
Crockett Hotel

Crockett Hotel

3 out of 5
320 Bonham San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $128 per night from Feb 18 to Feb 19
CA $128
CA $151 total
Feb 18 - Feb 19
includes taxes & fees
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Our guests praise the pool and the restaurant ...
Room was clean except for some stains on carpet. Bathroom was clean but Faucets in tub and sink were dripping water pressure was very good.staff was friendly and helpful. Location is excellent can walk anywhere

Reviewed on Feb 7, 2026

Opens in a new windowCrockett Hotel
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $121 per night from Feb 10 to Feb 11
CA $121
CA $144 total
Feb 10 - Feb 11
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Very courteous and helpful staff at front desk.

Reviewed on Feb 2, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $138 per night from Feb 20 to Feb 21
CA $138
CA $164 total
Feb 20 - Feb 21
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy a free area shuttle, room service, and a 24-hour fitness center. Our guests praise the helpful ...
Everything

Reviewed on Feb 6, 2026

Opens in a new windowSan Antonio Marriott Northwest Medical Center
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
Super clean! Very nice staff! Thank you for the stay!

Reviewed on Feb 7, 2026

Opens in a new windowRiverwalk Plaza
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

3 out of 5
303 Blum Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $97 per night from Feb 15 to Feb 16
CA $97
CA $142 total
Feb 15 - Feb 16
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Room was clean and breakfast was really good. Lots of waffle makers and coffee pots. Easy walk to River Walk or to Convention Center. Will definitely stay here again.

Reviewed on Feb 7, 2026

Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Park Inn by Radisson

Park Inn by Radisson

2 out of 5
7500 Louis Pasteur Drive San Antonio TX
Fully refundableReserve now, pay when you stay
The price is CA $86 per night from Feb 22 to Feb 23
CA $86
CA $100 total
Feb 22 - Feb 23
includes taxes & fees
Stay at this motel in San Antonio. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
Room was clean and I enjoyed it.

Reviewed on Feb 4, 2026

Opens in a new windowPark Inn by Radisson
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Medical Center District Hotel Guide

Don’t keep your travel plans on repeat year after year. The same city with the same hotel every season will bore you and give you an itch to go looking for something new. Expand your geographical horizons to more than just those five blocks around your usual haunt.

Nowhere else can you find better deals on Medical Center District area hotels. You’ll find the best prices on the quirky, the haunted, the old, the new, and the legendary. If you’re wondering what side of the pricing scale some of these hotels fall on, you need not to worry. Compare cheap hotels near Medical Center District to find the perfect one to will fit your budget.

Leave the ordinary routine you’re set on behind and go. Go anywhere you want. Anywhere that makes you think, “I wonder what that’s like?” Part of Travelocity’s mission is to get you off-the-beaten path and the hotels near Medical Center District are perfect for that. Find your new favorite watering hole on a quiet street. Discover a place to escape for the weekend with tasty local fare and unique sights. We want you to consider the places outside your normal comfort zone. Browse our selection and find the ideal hotel, in a place you’d like to explore.

Recent Medical Center District hotel reviews by fellow wanderers